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소회향이 허혈성 뇌혈관 질환에 미치는 실험적 연구

The Experimental Study of FOENICULI FRUCTUS on the Ischemic Cerebrovascular Disease

정현우|김남순|강성용
대한한방신경정신과학회 (The Korean Society Of Oriental Neuropsychiatry)|2007.03|동의신경정신과학회지 (The Korean Society of Oriental Neuropsychiatry)|제18권 제1호|pp. 185-196

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참고문헌

주제분류한의학

초록

Abstract

Objective : This experimental Study was designed to investigate the effects of FOENICULI FRUCTUS(FF) on the change of inhibition lactate dehydrogenase(LDH) activity in neuronal cells and cytokines production in serum of cerebral ischemic rats.Method : FOENICULI FRUCTUS(FF)freeze dry powder and FF on the LDH activity in neuronal cells. Changes of FF on the physiological parameters(PaO2, PaCO2, MABP and HR) in crerbral ischemic rats. Effects of FF on the IL-1beta production, TNF-α production, TGF-β production, and IL-10 in serum of cerebral ischemic rats.MCAO : cytokines production of serum by drawing from femoral arterial blood after MCAO 1 hr. Reperfusion : cytokines production of serum by drawing from femoral arterial blood after reperfusion 1 hr.Results and Conclusion :1. FF did not inhibit lactate dehydrogenase(LDH) activity in neuronal cells.2. In serum by drawing from femoral arterial blood after middle cerebral arterial occlusion(MCAO) 1 hr and reperfusion 1 hr, sample group was significantly decreased IL-1β production compared with control group.3. In serum by drawing from femoral arterial blood after MCAO 1 hr and reperfusion 1 hr, sample group was significantly decreased TNF-α production compared with control group.4. In serum by drawing from femoral arterial blood after MCAO 1 hr and reperfusion 1 hr, sample group was significantly increased TGF-β production compared with control group.5. In serum by drawing from femoral arterial blood after reperfusion 1 hr, sample group was significantly increased IL-10 production compared with control group. This results were suggested that FF had inhibitive effect on the brain damage by inhibited LDH activity, IL-1β and TNF-α production, but accelerated TGF-β production and IL-10 production.

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