凉膈散火湯이 고지혈증 흰쥐의 중대뇌동맥 폐쇄에 의한 뇌경색에 미치는 영향
Neuroprotective Effect of Yanggyuksanhwa-tang on Cerebral Infarction Induced by MCAO in Hyperlipidemic Rats
0
조회
0
다운로드
6
인용
0
참고문헌
초록
Abstract
Objectives : Yanggyuksanhwa-tang is a prescription used for cerebral infarction clinically it is known that this formula reduces body fat, serum cholesterol and triglyceride in hyperglycemia and obesity patients. According to previous research data, controlling these types of lipid is considered to decrease the risk of cerebral infarction. Based on this fact, we investigated the relationship between hyperlipidemia and cerebral infarction, and the effect of Yanggyuksanhwa-tang on hyperlipidemic cerebral infarction. Methods : We induced cerebral infarction by middle cerebral artery occlusion (MCAO) in high-fat diet rats, and the rats were administered Yanggyuksanhwa-tang.Results : Infarct area and serum lipid were measured, and the level of elements such as c-Fos, Bax and caspase-3 in penumbra of infarct were expressed by immunohistochemical staining. Conclusions : Yanggyuksanhwa-tang showed neuroprotective effect through preventing neuronal cell apoptosis as well as reducing serum lipid level in hyperlipidemic condition.
참고문헌 (34)
- "Role of lipid modifying therapy in the prevention of initial and recurrent stroke", 13(6), pp.645~651 (2002)
- "Blood pressure cholesterol and stroke in Eastern Asia", 352, pp.1801~1807 (1998)
- "Serum cholesterol levels and six-year mortality from stroke in 350 977 men screened for the multiple risk factor intervention trial", pp.904~10 (1989)
- "Blood Lipids in Brain Infarction Subtypes", 22(2), pp.101~108 (2006)
- "Heart Protection Study Collaborative Group Effects of cholesterol lowering with simvastatin on stroke and other major vascular events in 20,536 people with cerebrovascular disease or other high risk conditions", 363(9411), pp.757~767 (2004)
- "Statin therapy after acute ischemic stroke in the heart protection study is the role in recurrent stroke prevention now defined?", 35(9), pp.2233~2234 (2004)
- "Cerebral ischemia new risk factors", 17(1), pp.43~50 (2004)
- "뇌졸중의 역학적 동향에 대한 연구", 280, pp.509~513 (1999)
- "Lipids and stroke", 3(3), pp.170~176 (2003)
- "Effects of statins in ischemic stroke", 1(2), pp.151~161 (1999)
- "東醫四象處方集", pp.83~ (1975), 금강출판사
- "東醫四象新編", pp.20~54 (1974), 종합의원사
- "뇌졸중에 관한 임상통계적 연구", 10(1), pp.25~38 (1989)
- "양격산화탕이 gold thioglucose로 유발된 백서의 비만증에 미치는 효과", 17(2), pp.145~160 (1996)
- "급성기 중풍 환자에 대한 양격산화탕의 임상적 효능", 25(1), pp.111~117 (2004)
- "Temporal profile of ischemic tissue damage neutrophil response and vascular plugging following permanent and transient middle cerebral artery occlusion in the rat", pp.3~10 (1994)
- "Reversible middle cerebral artery occlusion without craniectomy in rats", 20, pp.84~91 (1989)
- "A semiautomated method for measuring brain infarct volume", 10(2), pp.290~3 (1990)
- "東醫壽世保元", pp.70~ (1964), 신일문화사
- "凉膈散火湯의 효능에 관한 실험적 연구", 7, pp.273~85 (1984)
- "십이미관중탕 양격산화탕 형방사백산이 백서의 혈압 및 국소 뇌혈류량에 미치는 영향", 9(2), pp.259~268 (1999)
- "지주막하출혈에 의한 뇌기저동맥의 형태학적 변화에 미치는 양격산화탕의 효과", 20(2), pp.146~156 (1999)
- "Lipids in ischemic stroke subtypes", 104(1), pp.13~19 (2004)
- "Cholesterol diastolic blood pressure and stroke 13,000 strokes in 450,000 people in 45 prospective cohorts", 346, pp.1647~1653 (1995)
- "HDL cholesterol total cholesterol and the risk of stroke in middle aged British men", 31, pp.1882~1892 (2000)
- "Low and high density lipoprotein cholesterol and ischemic cerebrovascular disease", 162, pp.993~999 (2002)
- "Different risk factors for different stroke subtypes", 30, pp.2535~2540 (1999)
- "Cholesterol reduction and stroke occurrence an overview of randomised clinical trials", 10, pp.85~92 (2000)
- "Differential expression of the immediate early genes c-fos and NGFI-B in the rat brain following transient forebrain ischemia", pp.206~16 (1994)
- "Mechanisms of apoptotic control", 407, pp.810~816 (2000)
- "Induction of caspase3 like protease may mediate delayed neuronal death in the hippocampus after transient cerebral ischemia", 18, pp.4914~4928 (1998)
- "Increased cardiomyocyte apoptosis following ischemia and reperfusion in dietinduced hypercholesterolemia relation to Bcl2 and Bax proteins and caspase3 activity", 37(4), pp.385~394 (2002)
- "Flavonoids protect neurons from oxidized low density lipoprotein induced apoptosis involving c Jun N terminal kinase JNK c Jun and caspase3", 358, pp.547~557 (2001)
- "Ethanol induced changes in the content of triglycerides ceramides and glucosylceramides in cultured neurons", 29(8), pp.1374~1383 (2005)
