蘇葉 추출물이 白鼠의 뇌허혈에 미치는 효과
Effects of Folium Perillae on Cerebral Ischemia in Rats
0
조회
0
다운로드
0
인용
0
참고문헌
초록
Abstract
Objectives : Folium perillae (FP) can relieve superficial pathogenic factors to dissipate cold and promote the circulation of qi and regulate the function of the stomach and is often used for interior qi-stagnation. We hypothesized that FP could rescue cerebral ischemia in rats.Methods : The present study was carried out to investigate the effects of FP on cerebral ischemia in terms of regional cerebral blood flow (rCBF) and mean arterial blood pressure (MABP) in rats. Finally, lactate dehydrogenase (LDH) release was investigated, too.Results : In this study, treatment with FP elevated rCBF and MABP levels in dose-dependent manner. Pre-treatment with indomethacin, an inhibitor of cyclooxygenase, inhibited rCBF increase induced by FP effectively. However, FP did not affect stability during cerebral reperfusion. Finally, FP significantly inhibited LDH activity in vitro.Conclusions : These results suggest that FP is useful to treat patient with diseases related to cerebral ischemia, because FP can increase rCBF and MABP.
참고문헌 (26)
- "뇌졸중의 역학과 병리기전", pp.5~17 (1993), 대한노인병학회
- "Stroke:The way things really are", 25, pp.1290~1294 (1994)
- "Duration of neuroprotective treatment for ischemic stroke", 29, pp.535~542 (1998)
- "당귀의 허혈성 뇌손상 억제작용 및 신경세포 보호효과", 18(4), pp.25~35 (2004)
- "신편중약대사전", pp.3436~3438 (1982), 신문풍출판공사
- "약용식물 추출물의 Helicobacter pylori 에 대한 항균활성", 31(3), pp.764~770 (1999)
- "蘇葉에 의한 알레르기 천식효과에 대한 연구", 19(3), pp.25~34 (2004)
- "A model of focal ischemic stoke in the rat", pp.738~743 (1986)
- "이우주의 약리학 강의", pp.82~ (1998), 의학문화사
- "Reversible middle cerebral artery occlusion without craniectomy in rats", pp.84~91 (1989)
- "Glutamate neurotoxicity and disease of the nervous system", pp.623~634 (1988)
- "사망원인 통계 연보" (2006), 통계청
- "Functional electrostimulation in poststroke rehabilitation ; a meta-analysis of the randomized controlled trials", 77(6), pp.549~553 (1996)
- "증례를 통한 임상신경해부학", pp.191~ (1998), 한우리
- "재관류 손상에서 뇌조직 아민 변동과 Free Radical과의 관련성", pp.2~8 (1990)
- "Animal models of focal and global cerebral ischemia", 44(2), pp.85~95 (2003)
- "Poly(ADP-ribose) polymerase, nitric oxide and cell death", 20(4), pp.171~181 (1999)
- "The role of neuronal growth factors in neurodegenerative disorders of the human brain", 27(1), pp.1~39 (1998)
- "Cerebral ischemia and trauma-different etiologies yet similar mechanisms ; neuroprotective opportunities", 39(1), pp.55~73 (2002)
- "Traumatic injury induces differential expression of cell death gene in organotypic brain slice cultures determined by complementary DNA array hybridization", 96(1), pp.131~139 (2000)
- "최근 뇌졸중에 대한 역학적 고찰", pp.280~286 (1991)
- "인체의 생리", pp.30~47 (1985), 서울대학교 출판부
- "Methylene blue inhibits hypoxic cerebral vasodilation in awake sheep", pp.2226~2232 (1992)
- "Comparison of the effects of NG-nitro-L -arginine and indomethacin on the hypercapnic cerebral blood flow increase in rats", pp.257~264 (1994)
- "Mechanisms of disease oxygen- derived free radicals in postischemic tissue injury", pp.159~163 (1985)
- "Lipopolysaccharide 세포독성에 대한 SNP 효과에 관한 연구" (2000)