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朱子讀書丸의 아밀로이드베타로 유발된 생쥐 알츠하이머모델에 대한 효과

Effects of Jujadokseo-hwan on Mice with Alzheimer's Disease Induced by Amyloid-β

임강현|고흥|경혁수
대한한방내과학회 (The Society Of Korean Oriental Internal Medicine)|2006.03|대한한방내과학회지 (The Journal of Korean Oriental Internal Medicine)|제27권 제1호|pp. 253-264

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Abstract

Abstract Object: This research investigated effects of Jujadokseo-hwan on mice with Alzheimer's Disease induced by amyloid-β. According to Dongyibogam, Jujadokseo-hwan can cure amnesia. Amyloid-β is believed to induce oxidative stress and inflammation in the brain, postulated to play important roles in the pathogenesis of Alzheimer's disease. In this way amyloid-β induces Alzheimer's Disease. Methods: In order to make an efficient prescription and cope with dementia, learning and memory functions of mice were tested on passive avoidance test and Y-maze task. NF-κB were measured from protein derived from the brain. RT-PCR was done for gene analysis. Primers were protein kinase B and NGF-α. Results: 1. Jujadokseo-hwan was effective for memory capacity on passive avoidance test. but noneffective for spatial memory capacity and locomotor activity on Y-maze task. 2. The measurement of NF-κB showed upward tendancies and the result of RT-PCR showed up-regulation when given Jujadokseo-hwan by mouth. Conclusion: Results suggest that Jujadokseo-hwan is effective on mice with Alzheimer's Disease induced by amyloid-β.

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