Clinical Characteristics of Optic Neuritis in Koreans Greater than 50 Years of Age
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Purpose: To report clinical characteristics of optic neuritis (ON) in Koreans >50 years of age. Methods: A retrospective chart review was performed on patients with ON between January 2000 and December 2009. We obtained the best-corrected visual acuity (BCVA), Goldmann perimetry, relative afferent pupillary defect (RAPD), and color function tests as well as brain magnetic resonance imaging (MRI) findings in patients who were in the acute stage of the disorder. Results: Nine eyes in eight patients were included. The mean age of patients at presentation was 60.5 years (range, 53 to 71 years). Six patients were female, and two were male. There was one patient with bilateral ON. The mean BCVA at presentation was 20 / 400 (no light perception-20 / 70). Eight eyes (89%) complained of pain with eye movement. Six eyes (66%) had disc edema. Central scotoma was the most common field defect. All eyes had color abnormalities. Five eyes in four patients showed abnormalities of the involved optic nerves on MRI. The patients were followed for a mean of 11.3 months (range, 2 to 34 months). All of the patients recovered to a BCVA of 20 / 40 or better within 2 months. On the last follow-up, the mean BCVA was 20/ 20 (20 / 40 to 20 / 16). Four eyes showed remnant central scotoma. One eye had remnant RAPD, and two eyes had mild color abnormalities. Conclusions: Although ON is uncommon in elderly patients, it can develop in patients >50 years of age, and clinical features of optic neuritis in elderly patients are similar to those of younger patients.
Abstract
Purpose: To report clinical characteristics of optic neuritis (ON) in Koreans >50 years of age. Methods: A retrospective chart review was performed on patients with ON between January 2000 and December 2009. We obtained the best-corrected visual acuity (BCVA), Goldmann perimetry, relative afferent pupillary defect (RAPD), and color function tests as well as brain magnetic resonance imaging (MRI) findings in patients who were in the acute stage of the disorder. Results: Nine eyes in eight patients were included. The mean age of patients at presentation was 60.5 years (range, 53 to 71 years). Six patients were female, and two were male. There was one patient with bilateral ON. The mean BCVA at presentation was 20 / 400 (no light perception-20 / 70). Eight eyes (89%) complained of pain with eye movement. Six eyes (66%) had disc edema. Central scotoma was the most common field defect. All eyes had color abnormalities. Five eyes in four patients showed abnormalities of the involved optic nerves on MRI. The patients were followed for a mean of 11.3 months (range, 2 to 34 months). All of the patients recovered to a BCVA of 20 / 40 or better within 2 months. On the last follow-up, the mean BCVA was 20/ 20 (20 / 40 to 20 / 16). Four eyes showed remnant central scotoma. One eye had remnant RAPD, and two eyes had mild color abnormalities. Conclusions: Although ON is uncommon in elderly patients, it can develop in patients >50 years of age, and clinical features of optic neuritis in elderly patients are similar to those of younger patients.
참고문헌 (16)
- Walsh FB, "Walsh and Hoyt’s clinicalneuro-ophthalmology. Vol. 1. 4th ed" (1982), Williams& Wilkins
- "The clinical profile of optic neuritis. Experience of the opticneuritis treatment trial. Optic Neuritis Study Group", ArchOphthalmol, 109, pp.1673~1678 (1991)
- Gerling J, "Visual field defectsin optic neuritis and anterior ischemic optic neuropathy:distinctive features", Graefes Arch Clin Exp Ophthalmol, 236, pp.188~192 (1998)
- Rizzo JF 3rd, "Use of magneticresonance imaging to differentiate optic neuritis and nonarteriticanterior ischemic optic neuropathy", Ophthalmology, 109, pp.1679~1684 (2002)
- Froehlich J, "Use of pattern electroretinographyto differentiate acute optic neuritis from acute anteriorischemic optic neuropathy", Electroencephalogr Clin Neurophysiol, 92, pp.480~486 (1994)
- Rath EZ, "Correlation betweenoptic disc atrophy and aetiology: anterior ischaemic opticneuropathy vs optic neuritis", Eye (Lond), 17, pp.1019~1024 (2003)
- Holladay JT, "Proper method for calculating average visualacuity", J Refract Surg, 13, pp.388~391 (1997)
- Beck RW, "The course of visualrecovery after optic neuritis. Experience of the optic neuritistreatment trial", Ophthalmology, 101, pp.1771~1778 (1994)
- Rizzo JF 3rd, "Optic neuritis and ischemic opticneuropathy. Overlapping clinical profiles", Arch Ophthalmol, 109, pp.1668~1672 (1991)
- Nevalainen J, "Visual field defectsin acute optic neuritis: distribution of different types ofdefect pattern, assessed with threshold-related supraliminalperimetry, ensuring high spatial resolution", Graefes ArchClin Exp Ophthalmol, 246, pp.599~607 (2008)
- Chrousos GA, "Side effectsof glucocorticoid treatment. Experience of the opticneuritis treatment trial", JAMA, 269, pp.2110~2112 (1993)
- Rizzo JF 3rd, "Risk of developing multiple sclerosisafter uncomplicated optic neuritis: a long-term prospectivestudy", Neurology, 38, pp.185~190 (1988)
- Beck RW, "A randomized,controlled trial of corticosteroids in the treatment ofacute optic neuritis", NEngl J Med, 326, pp.581~588 (1992), The Optic Neuritis Study Group
- Beck RW, "The effect of corticosteroidsfor acute optic neuritis on the subsequent developmentof multiple sclerosis", N Engl J Med, 329, pp.1764~1769 (1993), The Optic Neuritis Study Group
- Alter M, "Optic neuritis in Orientalsand Caucasians", Neurology, 26, pp.631~639 (1973)
- Beck RW, "What we have learned from the OpticNeuritis Treatment Trial", Ophthalmology, 102, pp.1504~1508 (1995)