Association of Optic Neuritis with Neuromyelitis Optica Spectrum Disorder and Multiple Sclerosis in Korea
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Purpose: To describe the clinical characteristics and course of optic neuritis (ON) and its association with neuromyelitisoptica spectrum disorder (NMOSD) and multiple sclerosis (MS) in Korea. Methods: In this retrospective case series, 125 eyes of 91 Korean patients with ON were included. The medicaldocuments of adult patients with ON were retrospectively reviewed. Patients were assigned into idiopathicON, NMOSD, and MS groups according to the presence of an association with NMOSD or MS for subgroupanalysis. Clinical characteristics, disease course, and visual and systemic prognosis were analyzed. Results: During the mean follow-up of 3.7 years, 73 patients were diagnosed as idiopathic ON, 14 patients werediagnosed as NMOSD, and four patients developed definite MS. At the final visit, there were 13 (13%) eyes outof 100 eyes with idiopathic ON, nine (43%) eyes out of 21 eyes with NMOSD, and one (25%) eye out of foureyes with MS had a severe visual loss of 20 / 200 or less. The mean Expanded Disability Status Scale was 3.1± 1.5 in NMOSD and 1.8 ± 1.5 in the MS group at the final visit. In the NMOSD group, 50% of patients showedsevere visual loss in at least one eye or were unable to ambulate without assistance at the final visit (5.3 ± 4.4years after the initial episode of ON). Conclusions: Fourteen percent of patients showed positive results for NMO-immunoglobulin G test and 50%of patients with NMOSD showed a severe visual loss in at least one eye or were unable to ambulate withoutassistance. The proportion of MS was relatively low in Korean ON patients.
Abstract
Purpose: To describe the clinical characteristics and course of optic neuritis (ON) and its association with neuromyelitisoptica spectrum disorder (NMOSD) and multiple sclerosis (MS) in Korea. Methods: In this retrospective case series, 125 eyes of 91 Korean patients with ON were included. The medicaldocuments of adult patients with ON were retrospectively reviewed. Patients were assigned into idiopathicON, NMOSD, and MS groups according to the presence of an association with NMOSD or MS for subgroupanalysis. Clinical characteristics, disease course, and visual and systemic prognosis were analyzed. Results: During the mean follow-up of 3.7 years, 73 patients were diagnosed as idiopathic ON, 14 patients werediagnosed as NMOSD, and four patients developed definite MS. At the final visit, there were 13 (13%) eyes outof 100 eyes with idiopathic ON, nine (43%) eyes out of 21 eyes with NMOSD, and one (25%) eye out of foureyes with MS had a severe visual loss of 20 / 200 or less. The mean Expanded Disability Status Scale was 3.1± 1.5 in NMOSD and 1.8 ± 1.5 in the MS group at the final visit. In the NMOSD group, 50% of patients showedsevere visual loss in at least one eye or were unable to ambulate without assistance at the final visit (5.3 ± 4.4years after the initial episode of ON). Conclusions: Fourteen percent of patients showed positive results for NMO-immunoglobulin G test and 50%of patients with NMOSD showed a severe visual loss in at least one eye or were unable to ambulate withoutassistance. The proportion of MS was relatively low in Korean ON patients.
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