Initial Pattern of Optic Nerve Enhancement in Korean Patients with Unilateral Optic Neuritis
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초록
Purpose: The purpose of this study was to demonstrate whether the pattern of optic nerve enhancement inmagnetic resonance imaging (MRI) can help to differentiate between idiopathic optic neuritis (ON), neuromyelitisoptica (NMO), and multiple sclerosis (MS) in unilateral ON. Methods: An MRI of the brain and orbits was obtained in patients with acute unilateral ON. Patients with ONwere divided into three groups: NMO, MS, and idiopathic ON. The length and location of the abnormal opticnerve enhancement were compared for ON eyes with and without NMO or MS. The correlation between thepattern of optic nerve enhancement and the outcome of visual function was analyzed. Results: Of the 36 patients with ON who underwent an MRI within 2 weeks of the onset, 19 were diagnosedwith idiopathic ON, 9 with NMO, and 8 with MS. Enhancement of the optic nerve occurred in 21 patients(58.3%)and was limited to the orbital segment in 12 patients. Neither the length nor the location of the optic nerve enhancementwas significantly correlated with visual functions other than contrast sensitivity or the diagnosis ofidiopathic ON, MS, or NMO. Patients with greater extent of optic nerve sheath enhancement and more posteriorsegment involvement showed higher contrast sensitivity. Conclusions: Our data revealed that the pattern of optic nerve enhancement was not associated with diagnosisof idiopathic ON, NMO, or MS in Korean patients with unilateral ON. We believe further studies that includedifferent ethnic groups will lead to a more definitive answer on this subject.
Abstract
Purpose: The purpose of this study was to demonstrate whether the pattern of optic nerve enhancement inmagnetic resonance imaging (MRI) can help to differentiate between idiopathic optic neuritis (ON), neuromyelitisoptica (NMO), and multiple sclerosis (MS) in unilateral ON. Methods: An MRI of the brain and orbits was obtained in patients with acute unilateral ON. Patients with ONwere divided into three groups: NMO, MS, and idiopathic ON. The length and location of the abnormal opticnerve enhancement were compared for ON eyes with and without NMO or MS. The correlation between thepattern of optic nerve enhancement and the outcome of visual function was analyzed. Results: Of the 36 patients with ON who underwent an MRI within 2 weeks of the onset, 19 were diagnosedwith idiopathic ON, 9 with NMO, and 8 with MS. Enhancement of the optic nerve occurred in 21 patients(58.3%)and was limited to the orbital segment in 12 patients. Neither the length nor the location of the optic nerve enhancementwas significantly correlated with visual functions other than contrast sensitivity or the diagnosis ofidiopathic ON, MS, or NMO. Patients with greater extent of optic nerve sheath enhancement and more posteriorsegment involvement showed higher contrast sensitivity. Conclusions: Our data revealed that the pattern of optic nerve enhancement was not associated with diagnosisof idiopathic ON, NMO, or MS in Korean patients with unilateral ON. We believe further studies that includedifferent ethnic groups will lead to a more definitive answer on this subject.
참고문헌 (32)
- Rodriguez M, "Optic neuritis: a population-based study in Olmsted County, Minnesota", Neurology, 45, pp.244~250 (1995)
- Lucchinetti CF, "A role for humoral mechanisms in the pathogenesis of Devic’s neuromyelitis optica", Brain, 125(Pt 7), pp.1450~1461 (2002)
- Mandler RN, "Devic’s neuromyelitis optica: a clinicopathological study of 8 patients", Ann Neurol, 34, pp.162~168 (1993)
- Lefkowitz D, "Neuromyelitis optica with unusual vascular changes", Arch Neurol, 41, pp.1103~1105 (1984)
- Stansbury FC, "Neuromyelitis optica; presentation of five cases, with pathologic study, and review of literature", Arch Ophthal, 42, pp.292~ (1949)
- Scott GI, "Neuromyelitis optic", Am J Ophthalmol, 35, pp.755~764 (1952)
- Herges K, "Protective effect of an elastase inhibitor in a neuromyelitis optica-like disease driven by a peptide of myelin oligodendroglial glycoprotein", Mult Scler, 18, pp.398~408 (2012)
- Krumbholz M, "Interferon-beta increases BAFF levels in multiple sclerosis: implications for B cell autoimmunity", Brain, 131(Pt 6), pp.1455~1463 (2008)
- Palace J, "Interferon Beta treatment in neuromyelitis optica: increase in relapses and aquaporin 4 antibody titers", Arch Neurol, 67, pp.1016~1017 (2010)
- Tanaka M, "Interferon-beta(1b) treatment in neuromyelitis optica", Eur Neurol, 62, pp.167~170 (2009)
- Barnett MH, "Massive astrocyte destruction in neuromyelitis optica despite natalizumab therapy", Mult Scler, 18, pp.108~112 (2012)
- Kirveskari J, "Expression of alpha4-integrins on human neutrophils", J Leukoc Biol, 68, pp.243~250 (2000)
- Wingerchuk DM, "Revised diagnostic criteria for neuromyelitis optica", Neurology, 66, pp.1485~1489 (2006)
- Beck RW, "Visual function more than 10 years after optic neuritis: experience of the optic neuritis treatment trial", Am J Ophthalmol, 137, pp.77~83 (2004)
- Pau D, "Optic neuritis", Eye (Lond), 25, pp.833~842 (2011)
- Khanna S, "Magnetic resonance imaging of optic neuritis in patients with neuromyelitis optica versus multiple sclerosis", J Neuroophthalmol, 32, pp.216~220 (2012)
- Bambach MR, "Estimating the human recovery costs of seriously injured road crash casualties", Accid Anal Prev, 85, pp.177~185 (2015)
- Polman CH, "Diagnostic criteria for multiple sclerosis: 2005 revisions to the McDonald Criteria", Ann Neurol, 58, pp.840~846 (2005)
- 강은숙, "Clinical Usefulness of Cell-based Indirect Immunofluorescence Assay for the Detection of Aquaporin-4 Antibodies in Neuromyelitis Optica Spectrum Disorder", Annals of Laboratory Medicine, 32(5), pp.331~338 (2012), 대한진단검사의학회
- Isayama Y, "Acute optic neuritis and multiple sclerosis", Neurology, 32, pp.73~76 (1982)
- Lim SA, "Optic neuritis in Singapore", Singapore Med J, 49, pp.667~671 (2008)
- Lin YC, "Low conversion rate to multiple sclerosis in idiopathic optic neuritis patients in Taiwan", Jpn J Ophthalmol, 50, pp.170~175 (2006)
- Wakakura M, "Baseline features of idiopathic optic neuritis as determined by a multicenter treatment trial in Japan: Optic Neuritis Treatment Trial Multicenter Cooperative Research Group (ONMRG)", Jpn J Ophthalmol, 43, pp.127~132 (1999)
- Wang JC, "The presentation, aetiology, management and outcome of optic neuritis in an Asian population", Clin Exp Ophthalmol, 29, pp.312~315 (2001)
- Beck RW, "Brain magnetic resonance imaging in acute optic neuritis: Experience of the Optic Neuritis Study Group", Arch Neurol, 50, pp.841~846 (1993)
- Hickman SJ, "The optic nerve sheath on MRI in acute optic neuritis", Neuroradiology, 47, pp.51~55 (2005)
- Fazzone HE, "Optic neuritis:correlation of pain and magnetic resonance imaging", Ophthalmology, 110, pp.1646~1649 (2003)
- Kupersmith MJ, "Contrast-enhanced MRI in acute optic neuritis: relationship to visual performance", Brain, 125(Pt 4), pp.812~822 (2002)
- Lim SA, "Magnetic resonance imaging in acute optic neuritis in Singapore", Ann Acad Med Singapore, 38, pp.821~826 (2009)
- Wingerchuk DM, "The spectrum of neuromyelitis optica", Lancet Neurol, 6, pp.805~815 (2007)
- Trobe JD, "Contrast sensitivity and other vision tests in the optic neuritis treatment trial", Am J Ophthalmol, 121, pp.547~553 (1996)
- Park KA, "Analysis of spectral domain optical coherence tomography measurements in optic neuritis:differences in neuromyelitis optica, multiple sclerosis, isolated optic neuritis and normal healthy controls", Acta Ophthalmol, 92, pp.e57~e65 (2014)