Differential Gene Expression in Cell Types of the Human Skeletal Muscle: A Bioinformatics-Based Meta-Review
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PURPOSE: This study evaluates the differences in the expression of genes frequently analyzed in the field of exercise science between the skeletal muscle tissue and various cell types that comprise the skeletal muscle tissue. METHODS: We summarized the genes and proteins expressed in the skeletal muscle that were published in “Exercise Science” journal from 2015 to present. Thereafter, we selected 15 genes and proteins that were the most analyzed genes and proteins in the skeletal muscle. These genes and proteins were horizontally compared for expression differences in skeletal muscle components and cultured cells based on NCBI Gene Expression Omnibus DataSets. RESULTS: The most analyzed genes (encoding analyzed proteins) in skeletal muscle tissues in “Exercise Science” were PPARGC1A, PPARD, MTOR, MAP1LC3A, MAP1LC3B, PRKAA1, AKT1, SLC2A4, MAPK1, COX4I1, MAPK14, MEF2A, MAPK8, RPS6KB1, and SOD1. Among them, PPARGC1A, AKT1, SLC2A4, MAPK1, and COX4I1 were specifically expressed in the skeletal muscle. However, expression of other genes was found to be significantly affected in other cell types of the skeletal muscle tissue. CONCLUSIONS: Genes such as PPARGC1A, which are specifically expressed in the skeletal muscle, may be analyzed without pre-treating (such as perfusion) the skeletal muscle tissue. However, expression of other genes may depend on the skeletal muscle cell type. Thus, in such instances, pretreatment, such as perfusion and isolation, should be considered
Abstract
PURPOSE: This study evaluates the differences in the expression of genes frequently analyzed in the field of exercise science between the skeletal muscle tissue and various cell types that comprise the skeletal muscle tissue. METHODS: We summarized the genes and proteins expressed in the skeletal muscle that were published in “Exercise Science” journal from 2015 to present. Thereafter, we selected 15 genes and proteins that were the most analyzed genes and proteins in the skeletal muscle. These genes and proteins were horizontally compared for expression differences in skeletal muscle components and cultured cells based on NCBI Gene Expression Omnibus DataSets. RESULTS: The most analyzed genes (encoding analyzed proteins) in skeletal muscle tissues in “Exercise Science” were PPARGC1A, PPARD, MTOR, MAP1LC3A, MAP1LC3B, PRKAA1, AKT1, SLC2A4, MAPK1, COX4I1, MAPK14, MEF2A, MAPK8, RPS6KB1, and SOD1. Among them, PPARGC1A, AKT1, SLC2A4, MAPK1, and COX4I1 were specifically expressed in the skeletal muscle. However, expression of other genes was found to be significantly affected in other cell types of the skeletal muscle tissue. CONCLUSIONS: Genes such as PPARGC1A, which are specifically expressed in the skeletal muscle, may be analyzed without pre-treating (such as perfusion) the skeletal muscle tissue. However, expression of other genes may depend on the skeletal muscle cell type. Thus, in such instances, pretreatment, such as perfusion and isolation, should be considered
참고문헌 (42)
- Pilegaard H, "Transcriptional regulation of gene expression in human skeletal muscle during recovery from exercise", Am J Physiol Endocrinol Metab, 279(4), pp.E806~E814 (2000)
- Tunstall RJ, "Exercise training increases lipid metabolism gene expression in human skeletal muscle", Am J Physiol Endocrinol Metab, 283(1), pp.E66~E72 (2002)
- Chan KL, "Deconstructing metabolic inflammation using cellular systems", Am J Physiol Endocrinol Metab, 312(4), pp.E339~E347 (2017)
- Pillon NJ, "Innate immune receptors in skeletal muscle metabolism", Exp Cell Res, 360(1), pp.47~54 (2017)
- Jakubzick CV, "Monocyte differentiation and antigen-presenting functions", Nat Rev Immunol, 17(6), pp.349~362 (2017)
- "Illumina bodyMap2 transcriptome" (2013)[URL]
- (2021)[URL]
- "Muscle Atlas" (2017)[URL]
- Caspersen CJ, "Physical activity, exercise, and physical fitness : definitions and distinctions for health-related research", Public Health Rep, 100(2), pp.126~131 (1985)
- Baek KW, "Regular moderate aerobic exercise improves high-fat diet-induced nonalcoholic fatty liver disease via monoacylglycerol O-acyltransferase 1 pathway suppression", J Sport Health Sci, 9(5), pp.472~478 (2020)
- Kang YJ, "Differential gene expression profile by RNA sequencing study of elderly osteoporotic hip fracture patients with sarcopenia", J Orthop Translat, 29, pp.10~18 (2021)
- 백경완, "Relationship Between METTL21C Gene Expression and Exercise in Human Skeletal Muscle: A Meta-Analysis", 운동과학, 30(1), pp.102~109 (2021), 한국운동생리학회
- Kyung-Wan Baek, "Rodent Model of Muscular Atrophy for Sarcopenia Study", 대한골대사학회지, 27(2), pp.97~110 (2020), 대한골대사학회
- 유준일, "Two Types of Mouse Models for Sarcopenia Research: Senescence Acceleration and Genetic Modification Models", 대한골대사학회지, 28(3), pp.179~191 (2021), 대한골대사학회
- Baek KW, "Effects of lifelong spontaneous exercise on the M1", M2 macrophage polarization ratio and gene expression in adipose tissue of super-aged mice, 2020, pp.141, 111091~
- Fuller OK, "The protective effect of exercise in neurodegenerative diseases : the potential role of extracellular vesicles", Cells, 9(10), pp.2182~ (2020)
- Ntanasis-Stathopoulos J, "Epigenetic regulation on gene expression induced by physical exercise", J Musculoskelet Neuronal Interact, 13(2), pp.133~146 (2013)
- 이다인, "비만 마우스의 지방조직에서 일회성 운동의 Alpha-2-HS-Glycoprotein (fetuin A) 억제 효과", 운동과학, 28(1), pp.31~40 (2019), 한국운동생리학회
- 백경완, "고지방식이로 유도된 비만 마우스의 지방조직에서 일회성 운동이대식세포 표현형 비율 변화에 미치는 영향", 운동과학, 27(3), pp.232~243 (2018), 한국운동생리학회[DOI]
- Baek KW, "Differences in macrophage polarization in the adipose tissue of obese mice under various levels of exercise intensity", J Physiol Biochem, 76(1), pp.159~168 (2020)
- Valero T, "Mitochondrial biogenesis : pharmacological approaches", Curr Pharm Des, 20(35), pp.5507~5509 (2014)
- Dorn GW, 2nd, "Mitochondrial biogenesis and dynamics in the developing and diseased heart", Genes Dev, 29(19), pp.1981~1991 (2015)
- Sanchis-Gomar F, "Mitochondrial biogenesis in health and disease. Molecular and therapeutic approaches", Curr Pharm Des, 20(35), pp.5619~5633 (2014)
- Pilegaard H, "Exercise induces transient transcriptional activation of the PGC-1alpha gene in human skeletal muscle", J Physiol, 546(Pt 3), pp.851~858 (2003)
- (2021)[URL]
- 이동원, "8주 아세트산 투여가 마우스 지구력과 골격근의 지방대사에 미치는 영향", 운동과학, 30(1), pp.34~42 (2021), 한국운동생리학회
- 임창현, "일회성 저강도 고반복 저항성 운동이 골격근 합성신호 단백질 발현 및 위성세포 활성에 미치는 영향", 운동과학, 29(1), pp.77~85 (2020), 한국운동생리학회
- 안나영, "비만유도 노화 흰쥐의 복합 운동이 대동맥, 골격근 및 심근의HSP70 및 SOD1 발현에 미치는 영향", 운동과학, 29(3), pp.248~255 (2020), 한국운동생리학회[DOI]
- 임창현, "저산소 환경의 지구성 운동이 근육 위성세포의 활성 및 증식에 미치는 효과", 운동과학, 28(1), pp.22~30 (2019), 한국운동생리학회
- 오성희, "저항훈련은 랫 골격근에서 finasteride에 의해 유도된 단백질 항상성 교란을 개선시킨다", 운동과학, 28(2), pp.159~167 (2019), 한국운동생리학회
- 장용우, "오르막-내리막 운동형태에 따른 노화쥐 골격근 내 Wnt", BMP 신호전달이 골격근 형성기전에 미치는 영향, 2019, pp.28(2), 182~190[DOI]
- 이지현, "마이크로어레이 분석을 통한 일회성 유산소 운동이 마우스 비복근의 초기 에너지 대사관련 유전자에 미치는 영향", 운동과학, 28(1), pp.49~59 (2019), 한국운동생리학회
- 남궁현, "1회성 유산소 트레드밀 운동 강도가 수컷 마우스의 irisin 및 FNDC5 발현에 미치는 영향", 운동과학, 27(3), pp.209~216 (2018), 한국운동생리학회[DOI]
- 오승렬, "대규모 유전자 발현양상 분석을 통한 저항성 운동수행능력 유전자 발굴", 운동과학, 25(1), pp.10~17 (2016), 한국운동생리학회[DOI]
- 홍용식, "지구성 훈련이 노화 쥐 골격근의 자가포식 유동(flux)에 미치는 영향", 운동과학, 25(1), pp.50~59 (2016), 한국운동생리학회[DOI]
- 고진호, "PPARβ", δ 과발현은 PGC-1α ubiquitination의 감소를 통해 PGC-1α 단백질을 증가시킨다, 2015, pp.24(4), 407~414[DOI]
- 김상배, "유산소운동이 2형 당뇨쥐 골격근 미토콘드리아의 PGC-1α, AMPK 및 SOD 발현에 미치는 영향", 운동과학, 24(3), pp.297~303 (2015), 한국운동생리학회[DOI]
- 정수련, "운동 중 골격근 내 PGC-1α 농도는 PPARβ", δ를 통한 후전사 기전에 의하여 조절된다: PPARβ, 운동과학, pp.2015, 24(3)[DOI]
- 고진호, "지구성 운동에 의하여 증가된 PPARβ", δ는 NRF-1 promoter 활성을 통하여 생쥐 근육내 GLUT4 및 미토콘드리아 효소의 발현을 유도한다, 2015, pp.24(2), 153~160[DOI]
- 고진호, "PPARδ의 활성 또는 과발현은 PGC-1α 단백질의 분해를 지연시킨다", 운동과학, 24(1), pp.49~58 (2015), 한국운동생리학회[DOI]
- 윤상윤, "트레드밀 운동과 클로렐라 섭취가 흰 쥐 골격근의 MAP kinase 발현에 미치는 영향", 운동과학, 24(1), pp.67~74 (2015), 한국운동생리학회[DOI]
- 김상현, "일회성 지구성운동 시 MEF2를 통한 PPARδ의 GLUT4 생합성 조절", 운동과학, 24(1), pp.59~66 (2015), 한국운동생리학회[DOI]