비만 노쇠와 복합 운동
Obese Frailty and Combined Exercise
2
조회
0
다운로드
3
인용
0
참고문헌
키워드
초록
PURPOSE: Frailty is a geriatric syndrome that impairs the health and quality of life of older adults. While unintended weight loss is known to be a primary risk factor for frailty, obesity has also been closely associated with frailty. Combined exercise is thought to be an effective way of resolving obesity and frailty, but studies demonstrating the effect of combined exercise on obese frailty are lacking. In this review, we seek to understand the relevant mechanisms by exploring prior studies on obese frailty, and provide the implications of appropriate combined exercise interventions for obese frailty. METHODS: To collect data for this study, we used academic search systems such as Scopus, Google Scholar, PubMed, and Web of Science. The keywords used for the search were a combination of words such as ’obesity’, ‘frailty’, ‘combined or multicomponent exercise’, and ‘older or elderly adults’. RESULTS: The results from the 16 selected articles confirmed that combined exercise reduces body weight, percentage of body fat, and risk of falls. Moreover, it improves muscle strength, balance, and walking function of the obese frail population. CONCLUSIONS: As we have confirmed the positive outcomes on the combined exercise for obese frail older adults, an optimal exercise program needs to be presented. Older adults with obesity are recommended to exercise at least 2-3 times a week during the initial period. Further, they should begin with low-intensity walking, full-body exercise, balance, and flexibility exercises, then gradually increase the exercise volume. Moreover, to facilitate the positive outcomes of physical training and to encourage autonomy and enjoyment of exercise among obese frail older adults, a novel method and an individualized scientific exercise program need to be developed.
Abstract
PURPOSE: Frailty is a geriatric syndrome that impairs the health and quality of life of older adults. While unintended weight loss is known to be a primary risk factor for frailty, obesity has also been closely associated with frailty. Combined exercise is thought to be an effective way of resolving obesity and frailty, but studies demonstrating the effect of combined exercise on obese frailty are lacking. In this review, we seek to understand the relevant mechanisms by exploring prior studies on obese frailty, and provide the implications of appropriate combined exercise interventions for obese frailty. METHODS: To collect data for this study, we used academic search systems such as Scopus, Google Scholar, PubMed, and Web of Science. The keywords used for the search were a combination of words such as ’obesity’, ‘frailty’, ‘combined or multicomponent exercise’, and ‘older or elderly adults’. RESULTS: The results from the 16 selected articles confirmed that combined exercise reduces body weight, percentage of body fat, and risk of falls. Moreover, it improves muscle strength, balance, and walking function of the obese frail population. CONCLUSIONS: As we have confirmed the positive outcomes on the combined exercise for obese frail older adults, an optimal exercise program needs to be presented. Older adults with obesity are recommended to exercise at least 2-3 times a week during the initial period. Further, they should begin with low-intensity walking, full-body exercise, balance, and flexibility exercises, then gradually increase the exercise volume. Moreover, to facilitate the positive outcomes of physical training and to encourage autonomy and enjoyment of exercise among obese frail older adults, a novel method and an individualized scientific exercise program need to be developed.
참고문헌 (100)
- Jin KL, "The critical need to promote research of aging and aging-related diseases to improve health and longevity of the elderly population", Aging Dis, 6(1), pp.1~5 (2015)
- Borras C, "RasGrf1 deficiency delays aging in mice", Aging(Albany NY), 3(3), pp.262~276 (2011)
- Matheu A, "Delayed ageing through damage protection by the Arf", p53 pathway, 2007, pp.448(7151), 375~379
- Byrne C, "Ageing, muscle power and physical function : a systematic review and implications for pragmatic training interventions", Sports Med, 46(9), pp.1311~1332 (2016)
- Khan M, "Frailty in trauma patients : an emerging geriatric syndrome", Curr Surg Rep, 5(11), pp.30~ (2017)
- Rodriguez-Manas L, "Frailty in the clinical scenario", Lancet, 385(9968), pp.E7~E9 (2015)
- Li HF, "Frailty, inflammation, and immunity", Aging Dis, 2(6), pp.466~473 (2011)
- Fried LP, "Frailty in older adults : evidence for a phenotype", J Gerontol A Biol Sci Med Sci, 56(3), pp.M146~M56 (2001)
- Landre B, "Association between life-course obesity and frailty in older adults : findings in the GAZEL cohort", Obesity, 28(2), pp.388~396 (2020)
- Blaum CS, "The association between obesity and the frailty syndrome in older women : The women's health and aging studies", J Am Geriatr Soc, 53(6), pp.927~934 (2005)
- Poggiogalle E, "Treatment of body composition changes in obese and overweight older adults : insight into the phenotype of sarcopenic obesity", Endocrine, 47(3), pp.699~716 (2014)
- Park SW, "Accelerated loss of skeletal muscle strength in older adults with type 2 diabetes-the health, aging, and body composition study", Diabetes Care, 30(6), pp.1507~1512 (2007)
- Starr KNP, "Obesity and physical frailty in older adults : a scoping review of lifestyle intervention trials", J Am Med Dir Assoc, 15(4), pp.240~250 (2014)
- Cadore EL, "Muscle power training : a hallmark for muscle function retaining in frail clinical setting", J Am Med Dir Assoc, 19(3), pp.190~192 (2018)
- Villareal DT, "Aerobic or resistance exercise, or both, in dieting obese older adults", New Engl J Med, 376(20), pp.1943~1955 (2017)
- Buckinx F, "Effect of high-intensity interval training combined with L-Citrulline supplementation on functional capacities and muscle function in dynapenic-obese older adults", J Clin Med, 7(12), pp.561~ (2018)
- Hawley JA, "Molecular responses to strength and endurance training : are they incompatible?", Appl Physiol Nutr Me, 34(3), pp.355~361 (2009)
- Izquierdo M, "Once weekly combined resistance and cardiovascular training in healthy older men", Med Sci Sport Exer, 36(3), pp.435~443 (2004)
- Hakkinen A, "Effects of prolonged combined strength and endurance training on physical fitness, body composition and serum hormones in women with rheumatoid arthritis and in healthy controls", Clin Exp Rheumatol, 23(4), pp.505~512 (2005)
- Fern AK, "Benefits of physical activity in older adults programming modifications to enhance the exercise experience", Acsms Health FitJ, 13(5), pp.12~16 (2009)
- Villareal DT, "Weight loss, exercise, or both and physical function in obese older adults", New Engl J Med, 364(13), pp.1218~1229 (2011)
- OECD, "Health at a Glance 2017: OECD Indicators" (2017), OECD Publishing
- 김다미, "최근 10년 간 거주 지역에 따른 한국 성인의 식생활 및 비만 유병률 변화 : 제4기(2007~2009)와 제7기(2016~2018) 국민건강영양조사 자료를 이용하여", 대한지역사회영양학회지, 26(1), pp.37~47 (2021), 대한지역사회영양학회
- Shi SM, "Changes in predictive performance of a frailty index with availability of clinical domains", J Am Geriatr Soc, 68(8), pp.1771~1777 (2020)
- Martins BA, "Frailty prevalence using frailty index, associated factors and level of agreement among frailty tools in a cohort of Japanese older adults", Arch Gerontol Geriat, 84 (2019)
- Kojima G, "Prevalence of frailty in japan : a systematic review and meta-analysis", J Epidemiol, 27(8), pp.347~353 (2017)
- Moreno-Franco B, "Socioeconomic determinants of sarcopenic obesity and frail obesity in community-dwelling older adults : The Seniors-ENRICA Study", Sci Rep, 8(1), pp.10760~ (2018)
- Bylow K, "Obese frailty, physical performance deficits, and falls in older men with biochemical recurrence of prostate cancer on androgen deprivation therapy : a case-control study", Urology, 77(4), pp.934~940 (2011)
- 전덕영, "The Association between Frequency of Social Contact and Frailty in Older People: Korean Frailty and Aging Cohort Study (KFACS)", Journal of Korean Medical Science, 33(51), pp.1~8 (2018), 대한의학회
- Won CW, "Korean frailty and aging cohort study(KFACS) : cohort profile", BMJ Open, 10(4), pp.e035573~ (2020)
- Colleluori G, "Aerobic plus resistance exercise in obese older adults improves muscle protein synthesis and preserves myocellular quality despite weight loss", Cell Metab, 30(2), pp.261~273 (2019)
- Meng NH, "Effects of concurrent aerobic and resistance exercise in frail and pre-frail older adults a randomized trial of supervised versus home-based programs", Medicine(Baltimore), 99(29), pp.e21187~ (2020)
- Hanlon P, "Frailty and pre-frailty in middle-aged and older adults and its association with multimorbidity and mortality : a prospective analysis of 493737 UK Biobank participants", Lancet Public Health, 3(7), pp.E323~E332 (2018)
- Losa-Reyna J, "Effect of a short multicomponent exercise intervention focused on muscle power in frail and pre frail elderly : A pilot trial", Exp Gerontol, 115, pp.114~121 (2019)
- Villareal DT, "Effect of weight loss and exercise on frailty in obese older adults", Arch Intern Med, 166(8), pp.860~866 (2006)
- Jensen GL, "Obesity in older adults : relationship to functional limitation", Curr Opin Clin Nutr, 13(1), pp.46~51 (2010)
- 백경완, "Effects of Exercise on Physical Fitness and Strength According to the Frailty Level of Female Elderly with Hypertension", 운동과학, 29(4), pp.368~376 (2020), 한국운동생리학회
- Wilson D, "Frailty and sarcopenia : The potential role of an aged immune system", Ageing Res Rev, 36, pp.1~10 (2017)
- Hirani V, "Longitudinal associations between body composition, sarcopenic obesity and outcomes of frailty, disability, institutionalisation and mortality in community-dwelling older men : The Concord Health and Ageing in Men Project", Age Ageing, 46(3), pp.413~420 (2017)
- Cruz-Jentoft AJ, "Sarcopenia", Lancet, 393(10191), pp.2636~2646 (2019)
- Markofski MM, "Effect of age on basal muscle protein synthesis and mTORC1signaling in a large cohort of young and older men and women", Exp Gerontol, 65, pp.1~7 (2015)
- Feng Z, "The coordinate regulation of the p53 and mTOR pathways in cells", Proc Natl Acad Sci U S A, 102(23), pp.8204~8209 (2005)
- Mankhong S, "Experimental models of sarcopenia : bridging molecular mechanism and therapeutic strategy", Cells, 9(6), pp.1385~ (2020)
- Brunet A, "Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1(FOXO3a)", Mol Cell Biol, 21(3), pp.952~965 (2001)
- Sandri M, "Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy", Cell, 117(3), pp.399~412 (2004)
- Yang YJ, "An overview of the molecular mechanisms contributing to musculoskeletal disorders in chronic liver disease : osteoporosis, sarcopenia, and osteoporotic sarcopenia", Int J Mol Sci, 22(5), pp.2604~ (2021)
- Crepaldi G, "Sarcopenia and osteoporosis : a hazardous duet", J Endocrinol Invest, 28(10 Suppl), pp.66~68 (2005)
- Tanaka K, "Active vitamin d possesses beneficial effects on the interaction between muscle and bone", Biochem Bioph Res Co, 450(1), pp.482~487 (2014)
- Karasik D, "Genetics of the musculoskeletal system : a pleiotropic approach", J Bone Miner Res, 23(6), pp.788~802 (2008)
- Urano T, "Recent genetic discoveries in osteoporosis, sarcopenia and obesity", Endocr J, 62(6), pp.475~484 (2015)
- Hamrick MW, "The skeletal muscle secretome : an emerging player in muscle-bone crosstalk", Bonekey Rep, 11(1), pp.60~ (2012)
- Soysal P, "Inflammation and frailty in the elderly : a systematic review and meta-analysis", Ageing Res Rev, 31, pp.1~8 (2016)
- Shaw AC, "Aging of the innate immune system", Curr Opin Immunol, 22(4), pp.507~513 (2010)
- Salvioli S, "Immune system, cell senescence, aging and longevity-inflamm-aging reappraised", Curr Pharm Des, 19(9), pp.1675~1679 (2013)
- Lohman MC, "Obesity, dietary inflammation, and frailty among older adults : evidence from the national health and nutrition examination survey", J Nutr Gerontol Geriatr, 38(1), pp.18~32 (2019)
- Vendrell J, "Resistin, adiponectin, ghrelin, leptin, and proinflammatory cytokines : Relationships in obesity", Obes Res, 12(6), pp.962~971 (2004)
- Procaccini C, "Leptin as an immunomodulator", Mol Aspects Med, 33(1), pp.35~45 (2012)
- Tilg H, "Adipocytokines : mediators linking adipose tissue, inflammation and immunity", Nat Rev Immunol, 6(10), pp.772~783 (2006)
- Nave H, "Resistance of janus kinase-2 dependent leptin signaling in natural killer(NK)cells : a novel mechanism of NK cell dysfunction in diet-induced obesity", Endocrinology, 149(7), pp.3370~3378 (2008)
- Tilg H, "Role of adiponectin and PBEF", visfatin as regulators of inflammation : involvement in obesity-associated diseases, 2008, pp.114(3-4), 275~288
- Arita Y, "Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity", Biochem Bioph Res Co, 257(1), pp.79~83 (1999)
- Meyer MR, "Obesity, insulin resistance and diabetes : sex differences and role of oestrogen receptors", Acta Physiol, 203(1), pp.259~269 (2011)
- Midzak AS, "Leydig cell aging and the mechanisms of reduced testosterone synthesis", Mol Cell Endocrinol, 299(1), pp.23~31 (2009)
- Siiteri PK, "Adipose-Tissue as a Source of Hormones", Am J Clin Nutr, 45(1), pp.277~282 (1987)
- Baglietto L, "Circulating steroid hormone concentrations in postmenopausal women in relation to body size and composition", Breast Cancer Res Tr, 115(1), pp.171~179 (2009)
- Travison TG, "Changes in reproductive hormone concentrations predict the prevalence and progression of the frailty syndrome in older men : the concord health and ageing in men project", J Clin Endocr Metab, 96(8), pp.2464~2474 (2011)
- Carcaillon L, "Sex Differences in the association between serum levels of testosterone and frailty in an elderly population : the toledo study for healthy aging", Plos One, 7(3), pp.e32401~ (2012)
- Kadi F, "Cellular and molecular mechanisms responsible for the action of testosterone on human skeletal muscle. A basis for illegal performance enhancement", Brit J Pharmacol, 154(3), pp.522~528 (2008)
- Veldhuis JD, "Differential impact of age, sex steroid-hormones, and obesity on basal versus pulsatile growth-hormone secretion in men as assessed in an ultrasensitive chemiluminescence assay", J Clin Endocr Metab, 80(11), pp.3209~3222 (1995)
- Vlahopoulos S, "Recruitment of the androgen receptor via serum response factor facilitates expression of a myogenic gene", J Biol Chem, 280(9), pp.7786~7792 (2005)
- Smith EP, "Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man", New Engl J Med, 331(16), pp.1056~1061 (1994)
- Okura T, "Association of polymorphisms in the estrogen receptor alpha gene with body fat distribution", Int J Obesity, 27(9), pp.1020~1027 (2003)
- Gordon EH, "Physiological basis for sex differences in frailty", Curr Opin Physiol, 6, pp.10~15 (2018)
- Smith GI, "Muscle protein synthesis response to exercise training in obese, older men and women", Med Sci Sports Exerc, 44(7), pp.1259~1266 (2012)
- Armamento-Villareal R, "Changes in thigh muscle volume predict bone mineral density response to lifestyle therapy in frail, obese older adults", Osteoporosis Int, 25(2), pp.551~558 (2014)
- Beavers DP, "The independent and combined effects of intensive weight loss and exercise training on bone mineral density in overweight and obese older adults with osteoarthritis", Osteoarthr Cartilage, 22(6), pp.726~733 (2014)
- Latham NK, "A randomized, controlled trial of quadriceps resistance exercise and vitamin D in frail older people : the frailty interventions trial in elderly subjects(FITNESS)", J Am Geriatr Soc, 51(3), pp.291~299 (2003)
- Elmahgoub SS, "The effect of combined exercise training in adolescents who are overweight or obese with intellectual disability : the role of training frequency", J Strength Cond Res, 25(8), pp.2274~2282 (2011)
- Thompson PD, "ACSM's new preparticipation health screening recommendations from ACSM's guidelines for exercise testing and prescription, ninth edition", Curr Sports Med Rep, 12(4), pp.215~217 (2013)
- Jadczak AD, "Effectiveness of exercise interventions on physical function in community-dwelling frail older people : an umbrella review of systematic reviews", JBI Database System Rev Implement Rep, 16(3), pp.752~775 (2018)
- Villareal DT, "Regular multicomponent exercise increases physical fitness and muscle protein anabolism in frail, Obese, Older Adults", Obesity, 19(2), pp.312~318 (2011)
- Binder EF, "Effects of exercise training on frailty in community-dwelling older adults : results of a randomized, controlled trial", J Am Geriatr Soc, 50(12), pp.1921~1928 (2002)
- Cunha RM, "Postexercise hypotension after aquatic exercise in older women with hypertension : a randomized crossover clinical trial", Am J Hypertens, 31(2), pp.247~252 (2018)
- American College of Sports M, "American college of sports medicine position stand. Exercise and physical activity for older adults", Med Sci Sports Exerc, 41(7), pp.1510~1530 (2009)
- Garber CE, "American college of sports medicine position stand. Quantity and quality of exercise for developing and maintaining cardiorespiratory, musculoskeletal, and neuromotor fitness in apparently healthy adults: guidance for prescribing exercise", Med Sci Sports Exerc, 43(7), pp.1334~1359 (2011)
- Cadore EL, "Positive effects of resistance training in frail elderly patients with dementia after long-term physical restraint", Age, 36(2), pp.801~811 (2014)
- Cadore EL, "Multicomponent exercises including muscle power training enhance muscle mass, power output, and functional outcomes in institutionalized frail nonagenarians", Age(Dordr), 36(2), pp.773~785 (2014)
- Cadore EL, "Effects of different exercise interventions on risk of falls, gait ability, and balance in physically frail older adults : a systematic review", Rejuvenation Res, 16(2), pp.105~114 (2013)
- Buchner DM, "Preventing frail health", Clin Geriatr Med, 8(1), pp.1~17 (1992)
- Serra-Rexach JA, "Short-term, light-to moderate-intensity exercise training improves leg muscle strength in the oldest old : a randomized controlled trial", J Am Geriatr Soc, 59(4), pp.594~602 (2011)
- Brown M, "Low-intensity exercise as a modifier of physical frailty in older adults", Arch Phys Med Rehabil, 81(7), pp.960~965 (2000)
- Jones GR, "Community exercise program for older adults recovering from hip fracture : a pilot study", J Aging Phys Act, 14(4), pp.439~455 (2006)
- Liu CJ, "Progressive resistance strength training for improving physical function in older adults", Cochrane Database Syst Rev, (3), pp.CD002759~ (2009)
- Lord SR, "The effect of group exercise on physical functioning and falls in frail older people living in retirement villages : a randomized, controlled trial", J Am Geriatr Soc, 51(12), pp.1685~1692 (2003)
- Mohler MJ, "Motor performance and physical activity as predictors of prospective falls in community-dwelling older adults by frailty level : application of wearable technology", Gerontology, 62(6), pp.654~664 (2016)
- Lee PG, "Exercise prescriptions in older adults", Am Fam Physician, 95(7), pp.425~432 (2017)
- Stathokostas L, "Flexibility training and functional ability in older adults : a systematic review", J Aging Res, 2012, pp.306818~ (2012)
- Watt JR, "Effect of a supervised hip flexor stretching program on gait in frail elderly patients", PM R, 3(4), pp.330~335 (2011)
- Tremblay MS, "New canadian physical activity guidelines", Appl Physiol Nutr Me, 36(1), pp.36~46 (2011)
- Bray NW, "Exercise prescription to reverse frailty", Appl Physiol Nutr Metab, 41(10), pp.1112~1116 (2016)
