신체 활동의 분자 전달체 컨소시엄(MoTrPAC) 연구동향과 운동과학 적용
Research Trends on MoTrPAC and Exercise Science Applications
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
PURPOSE: Exercise plays a crucial role in maintaining human health and is widely recognized for its effectiveness in preventing and managing chronic diseases. However, the molecular mechanisms by which exercise exerts its beneficial effects on the body remain unclear. The Molecular Transducers of Physical Activity Consortium (MoTrPAC) is a collaborative research initiative that brings together multiple institutions and organizations to investigate the molecular mechanisms of exercise. METHODS: This article provides a comprehensive overview of the MoTrPAC, detailing its structure, research strategies, and methodologies. We reviewed the consortium’s primary research objectives, methodologies, key findings, and potential applications in exercise science. This analysis was conducted through a systematic review of online databases and search engines, including PubMed, Web of Science, and Google Scholar. RESULTS: The MoTrPAC uses animal models and human studies to explore the physiological effects of exercise on various tissues. Research by the consortium has demonstrated that different types and intensities of exercise induce specific gene expression changes, activate diverse metabolic pathways, such as fatty acid oxidation, glucose metabolism, and protein synthesis, and restructure protein interaction networks in muscle tissue. These studies have identified novel biomarkers that can be used to assess the molecular effects of exercise. CONCLUSIONS: MoTrPAC significantly advances our understanding of the molecular mechanisms underlying the effects of exercise. The consortium’s findings have the potential to inform the development of personalized exercise prescriptions and health management strategies. Future research should include more diverse populations and investigate the long-term effects of exercise to enhance our understanding of the profound impact of physical activity on human health.
Abstract
PURPOSE: Exercise plays a crucial role in maintaining human health and is widely recognized for its effectiveness in preventing and managing chronic diseases. However, the molecular mechanisms by which exercise exerts its beneficial effects on the body remain unclear. The Molecular Transducers of Physical Activity Consortium (MoTrPAC) is a collaborative research initiative that brings together multiple institutions and organizations to investigate the molecular mechanisms of exercise. METHODS: This article provides a comprehensive overview of the MoTrPAC, detailing its structure, research strategies, and methodologies. We reviewed the consortium’s primary research objectives, methodologies, key findings, and potential applications in exercise science. This analysis was conducted through a systematic review of online databases and search engines, including PubMed, Web of Science, and Google Scholar. RESULTS: The MoTrPAC uses animal models and human studies to explore the physiological effects of exercise on various tissues. Research by the consortium has demonstrated that different types and intensities of exercise induce specific gene expression changes, activate diverse metabolic pathways, such as fatty acid oxidation, glucose metabolism, and protein synthesis, and restructure protein interaction networks in muscle tissue. These studies have identified novel biomarkers that can be used to assess the molecular effects of exercise. CONCLUSIONS: MoTrPAC significantly advances our understanding of the molecular mechanisms underlying the effects of exercise. The consortium’s findings have the potential to inform the development of personalized exercise prescriptions and health management strategies. Future research should include more diverse populations and investigate the long-term effects of exercise to enhance our understanding of the profound impact of physical activity on human health.
참고문헌 (16)
- Blair SN, "A prospective study of healthy men and women", pp.2395~2401 (1989), JAMA
- Neufer PD, "Understanding the cellular and molecular mechanisms of physical activity-induced health benefits", Cell Metab, 22(1), pp.4~11 (2015)
- Booth FW, "Lack of exercise is a major cause of chronic diseases", Compr Physiol, 2(2), pp.1143~1211 (2012)
- Sanford JA, "Molecular Transducers of Physical Activity Consortium(MoTrPAC) : Mapping the Dynamic Responses to Exercise", Cell, 181(7), pp.1464~1474 (2020)
- Molecular Transducers of Physical Activity Consortium (MoTrPAC), "Health NIo", Office of Strategic Coordination-The Common Fund: USA, ~ (2016)
- Sharples AP, "A multi-epigenomic map of endurance exercise training", Trends Genet (2024)
- MoTrPAC Study Group, "Temporal dynamics of the multi-omic response to endurance exercise training", Nature, 629(8010), pp.174~183 (2024)
- Schenk S, "Physiological adaptations to progressive endurance exercise training in adult and aged rats: insights from the Molecular Transducers of Physical Activity Consortium (MoTrPAC)", Function (Oxf), 5(4) (2024)
- Noone J, "Understanding the variation in exercise responses to guide personalized physical activity prescriptions", Cell Metab, 36(4), pp.702~724 (2024)
- Group MR, "Molecular Transducers of Physical Activity Consortium (MoTrPAC):Human Studies Design and Protocol", J Appl Physiol (2024)
- Many GM, "Sexual dimorphism and the multi-omic response to exercise training in rat subcutaneous white adipose tissue", Nat Metab, 6(5), pp.963~979 (2024)
- Amar D, "The mitochondrial multi-omic response to exercise training across tissues", bioRxiv (2023)
- Nair VD, "Molecular adaptations in response to exercise training are associated with tissuespecific transcriptomic and epigenomic signatures", Cell Genom, 4(6), pp.100421~ (2024)
- Chambers TL, "Multitissue responses to exercise : a MoTrPAC feasibility study", J Appl Physiol(1985), 135(2), pp.302~315 (2023)
- Vetr NG, "The impact of exercise on gene regulation in association with complex trait genetics", Nat Commun, 15(1), pp.3346~ (2024)
- Amar D, "The mitochondrial multi-omic response to exercise training across rat tissues", Cell Metab, 36(6), pp.1411~1429 (2024)