Alprazolam과 Fluoxetine이 기억력과 인지 기능에 미치는 영향

Abstract

The benzodiazepines have been reported to cause anterograde amnestic effects. There are also some report that the fluoxetine may be the cause of amnestic effects. The aim of this study was to investigate the effect of alprazolam and fluoxetine on memory and cognitive function. Alprazolam is popular intermediate-acting benzodiazepines and fluoxetine is one of SSRI which is being used most frequently. The subjects were 9 outpatients who visited to Psychiatry Department of Kyungpook National University Hospital. Some patients were under alprazolam medicatk>n(N=5, dosage:0.75-1.5mg) and the others were under fluoxetine medicatbn(N=4, dosage:20mg-40mg). The control group(N=6) was formed by normal volunteers, To measure the subjects' memory and cognitive functions, the Wechsler Memory Scale(WMS) and the Computerized Neuropsychological TestfSTIM system, neuroscan Inc, 1990) were used. The groups were examed by the WMS and the STIM before medication and after 8 weeks of taking medication. The data were analysed by Wilcoxon Matched-pairs Signed-ranks Test and Kolmogrov-Smtrnov 2-Sample Test. The result of this study were as follows : 1} There was no significant difference between pretreatment and posttreatment in alprazolam medication group. 2) There was no significant difference between pretreatment and posttreatment in fluoxetine medication group. 3) There was no significant difference between pretest and posttest in control group. 4) There was no significant difference between pretreatment and posttreatment among above three groups. In Summary, the effect of alprazolam and fluoxetine on memory and cognitive function has no statistical significance after 8 weeks treatment by therapeutic dosage.