정신분열병 환자에서 Olanzapine이 인지기능에 미치는 영향

Abstract

Objects ; The purpose of this study was to test the effects of olanzapine on cognitive functions in schizophrenic patients. Methods ; The subjects were 16 haloperidol-medicated schizophrenic patients and 15 risperidone-medicated schizophrenic patients, who participated in an eight-week crossover study from haloperidol and risperidone to olanzapine. Results ; The patients in the group of crossover from haloperidol to olanzapine showed significant improvement in Parkinson scale of ESRS and other cognitive functions except for verbal fluency. Negative scale of PANSS and cognitive functions such as verbal memory, verbal fluency, visual memory and executive function were significantly improved in patients in the group of crossover from risperidone to olanzapine. Conclusions ; These data suggest that olanzapine has some superior cognitive benefits relative to haloperidol and risperidone, but a larger sample replication study is necessary.