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공황장애에서 Paroxetine 단기약물치료가 심리적 상태에 미치는 영향

Effect of the Short-Term Treatment of Paroxetine on Psychological Ststes in Panic Disorder

김지혜|이동수|김율리|이소영|유범희|강은호
대한신경정신의학회 (Korean Neuropsychiatric Association)|2004.05|신경정신의학 (JOURNAL OF THE KOREAN NEUROPSYCHIATRIC ASSOCIATION)|제43권 제3호|pp. 312-319

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참고문헌

키워드

공황장애 · 파록세틴 · 처치반응 · 인지적개입.Panic disorder · Paroxetine · Treatment response · Cognitive intervention.
주제분류정신과학

초록

Abstract

Objectives：This study was designed to evaluate clinical effect of paroxetine treatment and to explore psychological predictors of treatment response. Methods：Patients (n=26) who met DSM-IV criteria for panic disorder with or without agoraphobia were treated by paroxetine for 12 weeks. We assessed symptom improvement using Clinical Global Impression (CGI), and clinical characteristics using Anxiety Sensitivity Index (ASI), Anxious Thoughts and Tendencies (AT & T), Agoraphobic Cognition Questionnaire (ACQ), Body Sensation Questionnaire (BSQ), Beck Anxiety Inventory (BAI), and Beck Depression Inventory (BDI). T-test, correlation analysis, and stepwise multiple regression analysis were performed. Results：Panic patients showed significant improvement in severity of illness and each clinical characteristic after 12 weeks of paroxetine treatment. There were significant correlations among severity of illness, anxiety, and depression, and subjective severity was related with catastrophic thoughts. The more catastrophic thoughts and the higher sensitivity of body sensation, Patients had the worse symptom improvement they shorved. Multiple regression analysis showed that catastrophic thought related to agoraphobia was the best predictor of symptom improvement (22%). Conclusion：This study suggests that short-term treatment of paroxetine is effective in panic disorder with or without agoraphobia, and that catastrophic thought could be a predictor of poor treatment response. Thus cognitive intervention on catastrophic thoughts may play an important role in symptom improvement in panic disorder. (J Korean Neuropsychiatr Assoc 2004; 43(3):312-319)

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