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Downregulation of Foxe1 by HR suppresses Msx1 expression in the hair follicles of HrHp mice

김성주|김정기|김봉규|박종근|Hwa-Young Lee|Jee-Hyun Choi
생화학분자생물학회 (Korean Society Of Biochemistry And Molecular Biology)|2011.07|BMB Reports|제44권 제7호|pp. 478-483

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참고문헌

키워드

Hair follicleMsx1Foxe1HairlessSfrp1
주제분류화학

초록

Hairless (HR), a transcriptional cofactor, is highly expressed in the skin and brain. To characterize the effects of HR expression in the skin, we examined its capacity for transcriptional regulation of its target genes in mouse skin and keratinocytes. We found that Foxe1 mRNA expression was suppressed in HR-overexpressing skin, as well as in HR-expressing keratinocytes. In turn, Msx1 expression was downregulated contingent on Foxe1 downregulation in skin and keratinocytes. We also found that expression of Sfrp1 was also correlated with that of Foxe1. Further investigation of the mechanisms involved in the transcriptional regulation of these genes will facilitate our understanding of the relationship among genes involved in hair follicle morphogenesis and cycling. [BMB reports 2011; 44(7): 478-483]

Abstract

Hairless (HR), a transcriptional cofactor, is highly expressed in the skin and brain. To characterize the effects of HR expression in the skin, we examined its capacity for transcriptional regulation of its target genes in mouse skin and keratinocytes. We found that Foxe1 mRNA expression was suppressed in HR-overexpressing skin, as well as in HR-expressing keratinocytes. In turn, Msx1 expression was downregulated contingent on Foxe1 downregulation in skin and keratinocytes. We also found that expression of Sfrp1 was also correlated with that of Foxe1. Further investigation of the mechanisms involved in the transcriptional regulation of these genes will facilitate our understanding of the relationship among genes involved in hair follicle morphogenesis and cycling. [BMB reports 2011; 44(7): 478-483]

참고문헌 (32)

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