풍부한 림프버팀질을 동반한 간의 암종 -2예 보고-
Carcinoma with Predominant Lymphoid Stroma in Hepatobiliary System - Report of 2 Cases -
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본 사례보고는 기존에 보고된 간실질에서 발생한 림프버팀질이 있는 암종 중, 특징적으로 LELC와 유사하면서 부분적으로 간세포암종과 담관세포암종의 특징을 모두 가진 암종과, LELC와 담관암종의 특징을 동시에 가진 암종을 비교 분석하였다. 림프버팀질을 가진 암종에 대한 다양한 임상연구가 진행되어 왔으나 그 중에서도 간에서 발생한 EBV 양성이고 LELC의 형태적 특징을 가진 암종에 대한 추가 연구가 이루어져야 할 것이다.
Abstract
Lymphoepithelioma-like carcinoma (LELC) is an undifferentiated carcinoma with predominant lymphocytic infiltration, which is associated with Epstein-Barr virus (EBV) in variable proportions. We report two cases of carcinoma with predominant lymphoid stroma in hepatobiliary system. The first case was a lymphoepithelioma-like undifferentiated carcinoma with focal differentiation of cholangiocarcinoma (cytokeratin 19+) and hepatocellular carcinoma in light microscopy. The infiltration of CD8+ T lymphocytes was observed in the tumor and the surrounding hepatic parenchyme. In this tumor, EBV was detected and LMP1 was positive immunohistochemically. The second case showed the mixed features of lymphoepithelioma-like carcinoma and cholangiocarcinoma with predominant lymphoid stroma. In this case, EBV was detected. LELC of hepatobiliary system is an entity distinguished from conventional carcinoma with lymphoid stroma, and its association with EBV warrants further research. (Korean J Hepatol 2007;13:222-227)
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