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Function of hepatocyte growth factor in gastric cancer proliferation and invasion

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초록

Cancer incidence has been increasing steadily and is the leading cause of mortality worldwide. Gastric cancer is still most common malignancy in Korea. Cancer initiation and progression are multistep processes involving various growth factors and their ligands. Among these growth factors, we have studied hepatocyte growth factor (HGF), which is associated with cell proliferation and invasion, leading to cancer and metastasis, especially in gastric cancer. We explored the intercellular communication between HGF and other surface membrane receptors in gastric cancer cell lines. Using complimentary deoxyribonucleic acid microarray technology, we found new genes associated with HGF in the stomach cancer cell lines, NUGC-3 and MKN-28, and identified their function within the HGF pathway. The HGF/N-methyl-N’-nitroso-guanidine human osteosarcoma transforming gene (c-MET) axis interacts with several molecules including E-cadherin, urokinase plasminogen activator, KiSS-1, Jun B, and lipocalin-2. This pathway may affect cell invasion and metastasis or cell apoptosis and is therefore associated with tumorigenesis and metastasis in gastric cancer.

Abstract

Cancer incidence has been increasing steadily and is the leading cause of mortality worldwide. Gastric cancer is still most common malignancy in Korea. Cancer initiation and progression are multistep processes involving various growth factors and their ligands. Among these growth factors, we have studied hepatocyte growth factor (HGF), which is associated with cell proliferation and invasion, leading to cancer and metastasis, especially in gastric cancer. We explored the intercellular communication between HGF and other surface membrane receptors in gastric cancer cell lines. Using complimentary deoxyribonucleic acid microarray technology, we found new genes associated with HGF in the stomach cancer cell lines, NUGC-3 and MKN-28, and identified their function within the HGF pathway. The HGF/N-methyl-N’-nitroso-guanidine human osteosarcoma transforming gene (c-MET) axis interacts with several molecules including E-cadherin, urokinase plasminogen activator, KiSS-1, Jun B, and lipocalin-2. This pathway may affect cell invasion and metastasis or cell apoptosis and is therefore associated with tumorigenesis and metastasis in gastric cancer.

참고문헌 (39)

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Overexpression of c-met Protein in Gastric Cancer and Role of uPAR as a Therapeutic TargetDong Suk Kim, Gu Lee, Hee Jung Kang, Hyun A Oh, Jae Lyun Lee, Kyung Hee Lee, Myung Soo Hyun, Sung Hwa Bae, Yong Gil Kim대한암학회 · Cancer Research and Treatment2003 · 제35권 제1호간세포성장인자가 하인두 편평세포암 세포주의 증식, 분산과 이동에 미치는 영향김철호, 문성균, 배준호, 이재호, 최은창대한이비인후과학회 · 대한이비인후과학회지 두경부외과학2005 · 제48권 제2호구강 및 구인두 편평세포암종에서 Hepatocyte Growth Factor와c-met 유전자 발현의 의의김진환, 노영수, 신형식, 안회영, 오소정, 조성진대한이비인후과학회 · 대한이비인후과학회지 두경부외과학2007 · 제50권 제8호Prevalence and Clinicopathological Significance of MET Overexpression and Gene Amplification in Patients with Gallbladder Carcinoma김예슬, 박성언, 방성식, 신수진, 장기석, 지승윤대한암학회 · Cancer Research and Treatment2020 · 제52권 제2호Expression of Hepatocyte Growth Factor/c-met by RT-PCR in Meningiomas김나래, 임원정, 조성진, 채양석대한병리학회 · Journal of Pathology and Translational Medicine2011 · 제45권 제5호하인두 편평세포암에서 간세포성장인자와 그 수용체인 c-Met의 발현김철호, 문성균, 배준호, 이재호, 최은창, 한재호대한이비인후과학회 · 대한이비인후과학회지 두경부외과학2004 · 제47권 제11호

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