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논문KCI 등재

하인두 편평세포암에서 간세포성장인자와 그 수용체인 c-Met의 발현

Expression of HGF/c-Met in Hypopharyngeal Squamous Cell Carcinoma

이재호|배준호|한재호|최은창|김철호|문성균
대한이비인후과학회 (Korean Society of Otorhinolaryngology-Head and Neck Surgery)|2004.11|대한이비인후과학회지 두경부외과학 (Korean Journal of Otorhinolaryngology-Head and Neck Surgery)|제47권 제11호|pp. 1135-1141

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참고문헌

키워드

간세포성장인자(HGF)·c-Met·하인두암.Hepatocyte Growth Factor (HGF)· c-Met· Hypopharyngeal cancer.
주제분류이비인후과학

초록

Abstract

Hepatocyte growth factor (HGF), a potent stimulator of hepatocyte growth, stimulates motility, invasivenes, proliferation, and morphogenesis of epithelium, and may be involved in physiologic and pathologic proceses such as embryogenesis, wound healing, organ regeneration, inflamation, and tumor invasion. So we examined the role of the HGF/c-Met on invasion and metastasis of hypopharyngeal squamous cell carcinoma ( ). We performed imunohistochemical stains on 40 normal mu-cosas and 40 SCs of hypopharynx with HGF antibody and c-Met antibody. For RT-PCR and Western blot, fresh normal tisues and cancer tisues in hypopharynx obtained from five patients were used. The positive rates of HGF and c-Met expression in hypopharyngeal SC were 77.5% and 70%, respectively. HGF staining was significantly correlated with lymph node metastasis and pathologic stage (p<0.05). c-Met staining was only significantly corelated with lymph node metastasis (p<0.05). The inc-reased expresssion of c-Met mRNA (RT-PCR) and protein (Western Blot) were detected in hypopharyngeal cancer tisue. These results suggest that HGF may play an important role in the progression of hypopharyngeal cancer.

참고문헌 (20)

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관련 논문AI추천

구강 및 구인두 편평세포암종에서 Hepatocyte Growth Factor와c-met 유전자 발현의 의의김진환, 노영수, 신형식, 안회영, 오소정, 조성진대한이비인후과학회 · 대한이비인후과학회지 두경부외과학2007 · 제50권 제8호간세포성장인자가 하인두 편평세포암 세포주의 증식, 분산과 이동에 미치는 영향김철호, 문성균, 배준호, 이재호, 최은창대한이비인후과학회 · 대한이비인후과학회지 두경부외과학2005 · 제48권 제2호후두편평세포암종에서 Vascular Endothelial Growth Factor의 발현김훈, 이강원, 이규석, 임도형, 홍영호대한이비인후과학회 · 대한이비인후과학회지 두경부외과학2003 · 제46권 제3호Expression of c-Met Is Different along the Location and Associated with Lymph Node Metastasis of Head and Neck Carcinoma김지은, 남수정, 윤지윤, 최지영대한병리학회 · Journal of Pathology and Translational Medicine2012 · 제46권 제6호비인강암에서 c-kit 단백의 발현 및 유전자 변이의 임상적 의미강일규, 권순영, 김인선, 백승국, 우정수, 이세우, 이승훈, 정광윤, 조승현대한이비인후과학회 · 대한이비인후과학회지 두경부외과학2007 · 제50권 제6호두경부 편평세포암종에서 전이와 예후 인자에 대한 연구김옥준, 서구종, 유선열, 최홍란대한구강악안면외과학회 · 대한구강악안면외과학회지2002 · 제28권 제1호

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