구강 및 구인두 편평세포암종에서 Hepatocyte Growth Factor와c-met 유전자 발현의 의의
Role of Hepatocyte Growth Factor and c-met Gene Expression in Oral Cavityand Oropharyngeal Squamous Cell Carcinoma
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Abstract
Background and Objectives：The hepatocyte growth factor (HGF)/c-Met signal pathway may play various roles in carcino-genesis of several organs. However, studies about this pathway in head and neck cancers, especially oral cavity and oropharyn-geal squamous cel carcinoma (SCC), are very rare. Our objectives are to evaluate the relationship between the mRNA and protein expression of HGF and c-met genes in oral cavity and oropharyngeal carcinomas. Subjects and Method：examined the mRNA expresion of HGF and c-Met by means of the immunohistochemistry (IHC) method and reverse tran-scription polymerase chain reaction (RT-PCR) in 40 cases of surgically resected oral cavity and oropharyngeal SCC and 10 cases of low grade dysplasia. Results：Using RT-PCR , HGF mRNA amplification was detected in 67.5% and 10% of carcinoma and dysplasia. c-Met mRNA over-expresion was detected in 57.5% and 20% of carcinoma and dysplasia. Using IHC, HGF and Conclusion：These results suggest that HGF/c-Met signal pathway may be associated with the development of oral cavity and oropharyngeal SCC. (Korean J Otorhinolaryngol-Head Neck Surg 2007 ;50 :684-9)
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