Influence of Prescribed Herbal and Western Medicine on Patients with Abnormal Liver Function Tests: A Retrospective Quasi-Experimental Study
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Objectives: The aim of this study was to investigate the safety and the efficacy of Korean herbal, western and combination medicine use in patients with abnormal liver function tests. Methods: We investigated nerve disease patients with abnormal liver function tests who were treated with Korean herbal,western and combination medicine at Dong-Eui University Oriental Hospital from January 2011 to August 2011. We compared aspartic aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and total bilirubin (T-bil) levels before and after taking medicine and excluded patients who had liver-related disease when admitted. Results: AST and ALT were decreased significantly in patients who had taken herbal, western medicine. AST, ALT and ALP were decreased significantly in patients who had taken combination medicine. Compare to herbal medicine, AST, ALT and ALP were decreased significantly in patients who had taken western medicine, and ALT and ALP were decreased significantly in patients who had taken combination medicine. There were no significant differences between western and combination medicine. Conclusions: This study suggests that prescribed Korean herbal medicine, at least, does not injure liver function for patients’, moreover, it was shown to be effective in patients with abnormal liver function tests.
Abstract
Objectives: The aim of this study was to investigate the safety and the efficacy of Korean herbal, western and combination medicine use in patients with abnormal liver function tests. Methods: We investigated nerve disease patients with abnormal liver function tests who were treated with Korean herbal,western and combination medicine at Dong-Eui University Oriental Hospital from January 2011 to August 2011. We compared aspartic aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and total bilirubin (T-bil) levels before and after taking medicine and excluded patients who had liver-related disease when admitted. Results: AST and ALT were decreased significantly in patients who had taken herbal, western medicine. AST, ALT and ALP were decreased significantly in patients who had taken combination medicine. Compare to herbal medicine, AST, ALT and ALP were decreased significantly in patients who had taken western medicine, and ALT and ALP were decreased significantly in patients who had taken combination medicine. There were no significant differences between western and combination medicine. Conclusions: This study suggests that prescribed Korean herbal medicine, at least, does not injure liver function for patients’, moreover, it was shown to be effective in patients with abnormal liver function tests.
참고문헌 (20)
- Lee DS., "A case of toxic hepatitis caused by the Chinese diet food", Korean J Med, 65(3), pp.689~692 (2003)
- Kim BU., "An Impact of Saeng-Gan-Geon-Bi-Tang on the Metabolism and Reproduction of the Liver and Bowels", J Korean Oriental Med, 22(1), pp.32~57 (1982)
- Kim YS., "An Impact of Long-term Administration of Herbal Medicine on the Injury of Liver", Kyung Hee Medicine, 15(1), pp.71~76 (1999)
- 박세정, "太陰人 약인성 간손상의 太陰調胃湯 치험 1례", 사상체질의학회지, 22(2), pp.135~142 (2010), 사상체질의학회
- 최홍식, "생간건비탕을 이용한 급성 약인성 간손상 치험 1례", 대한한방내과학회지, 25(4), pp.207~211 (2004), 대한한방내과학회
- 한창우, "한방병원에 입원한 환자군에서 간기능 검사 이상자의 빈도 조사", 대한한의학회지, 31(2), pp.109~113 (2010), 대한한의학회
- 윤영주, "약인성 간손상의 원인물질에 관한 국내연구의 체계적 고찰", 대한한의학회지, 30(2), pp.30~45 (2009), 대한한의학회
- Kim DJ., "A preliminary multicenter study for the detection of toxic hepatitis induced by various plant preparations and healthy foods and the development of nationwide reporting system of toxic hepatitis.", National Institute of Toxicological Research, 12 (2003)
- Lee JH., "Seventeen cases with herbal medicine-induced Hepatitis", Korean J Gastroenterol, 32(1), pp.69~74 (1998)
- Wai CT., "Drug-induced liver injury at an Asian center : a prospective study", Liver International, 27(4), pp.465~474 (2007)
- 이시형, "입원환자 한약투여와 약인성 간손상과의 관계", 대한한방내과학회지, 27(3), pp.572~578 (2006), 대한한방내과학회
- 백은경, "한약 장기복용이 발달장애아동의 간기능과 건강증진에 미치는 영향", 동의생리병리학회지, 20(2), pp.494~497 (2006), 대한동의병리학회
- Lesley Rees., "Imbuse orthodox medicine with the value of complemetary medicine", British Medical Journal., pp.119~120 (2001)
- Pittler MH., "Systematic Review : hepatotoxic events associated with herbal medicinal products", Aliment Pharmacol Ther, 18(5), pp.451~471 (2003)
- Ichiro Shimisu., "Effect of Sho-saiko-to, a Japanese Herbal Medicine on Hepatic Fibrosis in Rat", Hepatology, 29(1), pp.149~160 (1999)
- Department of Internal Medicine., "Clinical Internal Medicine 1st ed", pp.468~512 (2004), Korea Medical Book Publisher
- 천우정, "경주지역에서 식물제제에 의한 급성 간손상 환자의 임상적 고찰", 대한내과학회지, 63(2), pp.4~150 (2002), 대한내과학회
- 윤영주, "약인성 간손상의 원인물질에 관한 국내연구의 체계적 고찰", 대한한의학회지, 30(2), pp.30~45 (2009), 대한한의학회
- 김윤준, "간기능 검사 해석", 대한소화기학회지, 51(4), pp.219~224 (2008), 대한소화기학회[DOI]
- 윤영주, "한약 복용이 간기능에 미치는 영향 : 전향적 다기관 예비연구", 동의생리병리학회지, 23(3), pp.715~722 (2009), 대한동의병리학회