Entecavir와 한의약 치료를 병행한 후 HBV-DNA가 음전된 만성 B형 간염 환자 증례 보고
A Case Report of the Use of Traditional Korean Medicine to Treat a Patient with Chronic Hepatitis B Whose HBV-DNA Level Failed to Drop Below Undetectable Levels Following Long-term Treatment with Entecavir
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
The patient presented to the clinic with the complaint of severe fatigue. The patient had been diagnosed with chronic hepatitis B a number of years earlier. Although he had used entecavir, an antiviral agent, for over two years, his HBV-DNA level had not dropped below undetectable levels. The fatigue seemed to be associated with chronic hepatitis B. Traditional Korean medicine (TKM) therapy for chronic hepatitis B was administered in conjunction with entecavir and at the same dose. The excessive fatigue gradually decreased following the treatment. On the 28th day, laboratory tests revealed that the patient’s bilirubin level was slightly lower and that his HBV-DNA level had dropped below undetectable levels. The addition of TKM therapy may have contributed to the HBV-DNA clearance. No similar cases have been reported in Korea. Herein, we summarize the patient’s progress.
Abstract
The patient presented to the clinic with the complaint of severe fatigue. The patient had been diagnosed with chronic hepatitis B a number of years earlier. Although he had used entecavir, an antiviral agent, for over two years, his HBV-DNA level had not dropped below undetectable levels. The fatigue seemed to be associated with chronic hepatitis B. Traditional Korean medicine (TKM) therapy for chronic hepatitis B was administered in conjunction with entecavir and at the same dose. The excessive fatigue gradually decreased following the treatment. On the 28th day, laboratory tests revealed that the patient’s bilirubin level was slightly lower and that his HBV-DNA level had dropped below undetectable levels. The addition of TKM therapy may have contributed to the HBV-DNA clearance. No similar cases have been reported in Korea. Herein, we summarize the patient’s progress.
참고문헌 (18)
- Ott JJ, "Global epidemiology of hepatitis B virus infection: new estimates of age-specific HBsAg seroprevalence and endemicity", Vaccine, 30(12), pp.2212~2219 (2012)
- Korea centers for disease control and prevention, "Korea Health Statistics 2011: Korea National Health and Nutrition Examination Survey (KNHANES V-2)", pp.464~465 (2012), Korea centers for disease control and prevention
- Lozano R, ". Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010", Lancet, 380(9859), pp.2095~2128 (2012)
- Weinbaum C, "Recommendations for identification and public health management of persons with chronic hepatitis B virus infection", MMWR Recomm Rep, 57(RR-8), pp.1~20 (2008)
- 中华中医药学会, "中医内科常见病诊疗指南 西医 疾病部分", pp.122~129 (2008), 中国中医药出版社
- Woo HJ, "Liver system internal medicine", pp.9~ (2016), Nado publishing company
- 蔡禹錫, "董氏奇穴集成", pp.251~255 (1997), 一中社
- Zhang L, "Contemporary clinical research of traditional Chinese medicines for chronic hepatitis B in China: an analytical review", Hepatology, 51(2), pp.690~698 (2010)
- Scaglioni PP, "Recent advances in the molecular biology of hepatitis B virus", Baillieres Clin Gastroenterol, 10(2), pp.207~225 (1996)
- Chu CM, "The etiology of acute hepatitis superimposed upon previously unrecognized asymptomatic HBsAg carriers", Hepatology, 9(3), pp.452~456 (1989)
- Liaw YF, "Incidence, determinants and significance of delayed clearance of serum HBsAg in chronic hepatitis B virus infection: a prospective study", Hepatology, 13(4), pp.627~631 (1991)
- Alter HJ, "Type B hepatitis: the infectivity of blood positive for e antigen and DNA polymerase after accidental needlestick exposure", N Engl J Med, 295(17), pp.909~913 (1976)
- Iloeje UH, "Predicting cirrhosis risk based on the level of circulating hepatitis B viral load", Gastroenterology, 130(3), pp.678~686 (2006)
- rrault NA, "AASLD guidelines for treatment of chronic hepatitis B", Hepatology, 63(1), pp.261~283 (2016)
- "Drugs.com"[URL]
- Lai CL, "Entecavir versus lamivudine for patients with HBeAg-negative chronic hepatitis B", N Engl J Med, 354(10), pp.1011~1020 (2006)
- Jeong JS, "A case of repetitive drug-induced liver injury treated with Injinchunggan-tang", J Int Korean Med, pp.246~252 (2009)
- 김하연, "인진청간탕으로 호전된 스테로이드 부작용을 동반한 자가면역성 간염-원발성 담즙성 간경변증 중복증후군 1례", 대한한방내과학회지, 37(3), pp.560~567 (2016), 대한한방내과학회