천명이 있는 소아에서 인터페론-감마 유도 단백질 10 kDa의임상적 특성
Clinical characteristics of interferon-gamma-inducible protein of 10 kDa in children with wheezing
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Purpose: Recent studies have shown that interferon-gamma-inducible protein of 10 kDa (IP-10/CXCL10) levels is increased in acute bronchiolitis and asthma. The aim of this study was to examine the levels of IP-10 in children with wheezing and whether it corre- lates with other clinical variables. Methods: A total of 62 subjects children were hospitalized for lower respiratory tract infection with wheezing and visited the Emer- gency Department due to an acute exacerbation of asthma. IP-10 levels were measured using enzyme-linked immunosorbent as- say in the serum collected at admission. Serum IP-10 levels were evaluated for the relationships with age, sex, blood eosinophils counts, acute phase reactant, allergic sensitization, history of wheezing, and chest X-ray fi ndings. Results: Age showed a signifi cant negative correlation with serum IP-10 levels (P=0.002). The serum levels of IP-10 were also signifi - cantly increased in patients with pneumonic infiltration on X-rays compared to those with normal or hyperinflation (P<0.009). There was no signifi cant diff erence in the serum IP-10 level according to the other factors, including allergic sensitization. Conclusion: Serum IP-10 is signifi cantly associated with infl ammation of the lung and age, but not with allergic infl ammation.
Abstract
Purpose: Recent studies have shown that interferon-gamma-inducible protein of 10 kDa (IP-10/CXCL10) levels is increased in acute bronchiolitis and asthma. The aim of this study was to examine the levels of IP-10 in children with wheezing and whether it corre- lates with other clinical variables. Methods: A total of 62 subjects children were hospitalized for lower respiratory tract infection with wheezing and visited the Emer- gency Department due to an acute exacerbation of asthma. IP-10 levels were measured using enzyme-linked immunosorbent as- say in the serum collected at admission. Serum IP-10 levels were evaluated for the relationships with age, sex, blood eosinophils counts, acute phase reactant, allergic sensitization, history of wheezing, and chest X-ray fi ndings. Results: Age showed a signifi cant negative correlation with serum IP-10 levels (P=0.002). The serum levels of IP-10 were also signifi - cantly increased in patients with pneumonic infiltration on X-rays compared to those with normal or hyperinflation (P<0.009). There was no signifi cant diff erence in the serum IP-10 level according to the other factors, including allergic sensitization. Conclusion: Serum IP-10 is signifi cantly associated with infl ammation of the lung and age, but not with allergic infl ammation.
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