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Respiratory Syncytial Virus 세기관지염 환아의 비인두 분비물에서 ECP, RANTES, Eotaxin 치와 추적 관찰 후 천명 여부와의 연관성

ECP, RANTES, and Eotaxin in Respiratory Syncytial Virus Bronchiolitis: Relation to Subsequent Wheezing

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참고문헌

주제분류임상병리학

초록

Abstract

Background: Infants with respiratory syncytial virus (RSV) bronchiolitis are at increased risk of developing persistent wheezing and bronchial asthma later in life. Eosinophilrelated- inflammatory mechanisms play a role in RSV bronchiolitis and asthma. Objective: The aim of our study was to find a relationship between eosinophil cationic protein (ECP), RANTES, and eotaxin level in the nasophageal secretion of RSV bronchiolitis patients and subsequent wheezing. Method: ECP, RANTES, and eotaxin level in nasopharyngeal secretion were determined in 28 children hospitalized with RSV bronchiolitis. 24 children were followed for two years after the RSV bronchiolitis. Result: 12 out of 24 children experienced subsequent wheezing verified by their physicians. Children who had subsequent wheezing showed significantly higher level of ECP, RANTES, and eotaxin in the nasopharyngeal secretion than those who had not. There was a positive correlations between ECP and RANTES, ECP and eotaxin in RSV bronchiolitis patients. Conclusion: Nasopharyngeal ECP, RANTES, eotaxin may be useful in predicting the development of persistent wheezing in children affected by RSV bronchiolitis. (Korean J Asthma Allergy Clin Immunol 2007;27:235-240)

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관련 논문AI추천

Respiratory Syncytial Virus 감염에 의한 세기관지염의 면역반응박용민대한 소아알레르기 호흡기학회 · Allergy Asthma & Respiratory Disease2007 · 제17권 제2호Respiratory Syncytial Virus 세기관지염과 재발성 천명김현희대한천식알레르기학회 · 천식 및 알레르기2005 · 제25권 제4호영아 천식과 세기관지염 환아에서 급성기 면역반응의 차이금동혁, 김승준, 박문수, 심정연, 이은호, 정혜림대한 소아알레르기 호흡기학회 · Allergy Asthma & Respiratory Disease2002 · 제12권 제1호Respiratory syncytial virus 세기관지염에서비세척액내 호산구성 염증에 대한 TNF-α 역할허경, 김창근, 김효빈, 윤운기, 최준기대한 소아알레르기 호흡기학회 · Allergy Asthma & Respiratory Disease2008 · 제18권 제1호Respiratory Syncytial Virus에 의한 세기관지염에서 아토피 상태에 따른 면역 조절 사이토카인들의 차이김상경, 김소연, 김우택, 김진경, 양범석, 이경훈, 이준화, 정혜리, 최은진대한 소아알레르기 호흡기학회 · Allergy Asthma & Respiratory Disease2004 · 제14권 제1호소아의 하기도 감염에서 아토피 상태에 따른 혈청 Interleukin-8 및 RANTES 농도의 비교김수정, 김유진, 김진택, 김현숙, 김현희, 오은영, 윤종서, 이재금, 이준성, 이희수, 전윤홍, 최승준대한 소아알레르기 호흡기학회 · Allergy Asthma & Respiratory Disease2011 · 제21권 제2호

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