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유산소운동이 혈장 Endothelin-1 농도 및 혈관탄성에 미치는 영향

The effect of aerobic exercise on plasma endothelin-1 levels and vascular compliance

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초록

이은희, 김영준, 장성동, 김주홍, 문성진, 최진관. 유산소운동이 혈장 Endothelin-1 농도 및 혈관탄성에 미치는 영향. 운동과학, 제16권 제4호. 345-354, 2007. 본 연구는 12주간의 유산소 운동이 중년 남성의 혈중 Endothelin-1의 농도와 혈관 탄성에 미치는 영향을 구명하기 위하여 실시하였다. 연구대상은 40대 중년 남성 16명을 운동군(8명)과 대조군(8명)으로 나누었으며, 유산소 운동은 주 3회 이상, 60분/회, 60%HRR의 운동강도로 12주간 트레드밀 운동을 실시하여 얻은 결과는 다음과 같다. 체중, BMI와 %Fat은 운동 전, 후 두 집단 모두 유의한 변화는 나타나지 않았으며, Endothelin-1의 농도는 대조군은 운동 후 유의한 변화가 없는 반면, 운동군은 운동 후 유의하게(p<.05) 감소하였다. 혈관탄성은 오른쪽 손목, 왼쪽 손목, 오른쪽 발목, 왼쪽 발목 모두에서 운동군은 운동 후 유의하게 증가(p<.05)하였으나, 대조군은 유의한 변화가 없었다. 이상의 결과로 규칙적인 유산소 운동은 혈관 내피세포에서 생성, 분비되는 강력한 혈관수축물질인 Endothelin-1를 감소시키고 혈관탄성을 증가시켜 혈관순환계의 개선에 효과적인 것으로 사료된다.

Abstract

Lee, E.H., Kim, Y.J., Jang, S.D., Kim, J.H., Moon, S.J., Choi, J.K.. The Effect of Aerobic Exercise on Plasma Endothelin-1 Levels and Vascular Compliance. Exercise Science. 16(4): 345-354, 2007. The purpose of this study was to investigate the effects of 8 weeks aerobic exercise on plasma lipids, Endothelin-1 and vascular compliance in middle aged males(N=16). Subjects who participated in this study were divided into two groups. One was a exercise group(N=8, 47.4±4.87 years old) and a control group(N=8, 47.1±2.90 years old). Exercise group performed treadmill 1 hour a day, 3 times a week for 12weeks. We measured the changes of Endothelin-1, Cholesterol, HDL-C, LDL-C and Triglyceride in blood by collecting blood and Vascular compliance by PWV 3.0(K_M tec) before and after 12 weeks. The results of this study were as follow: Endothelin-1 was significantly(p<.05) decreased in exercise group, but there was no change in control group after 12weeks. Vascular compliance of all(right wrist, left wrist, right ankle, left ankle) were significantly(p<.05, p<.01) increased in exercise group, but there was no change in control group after 12weeks. Regular aerobic exercise is effective in improvement of vein circulatory system improving vascular compliance as well as decrease Endothelin-1 that is strong vein contracting compound that is created in vascular endothelial cell to middle age males who retrogression change of vascular begin.

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