항암치료에 반응하는 난소암 환자에서 항-Yo항체가 있는 부신생물 소뇌퇴행증 1예
Anti-Yo-associated paraneoplastic cerebellar degeneration in a patient with chemotherapy-responsive ovarian cancer: A case report with a review of literatures
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초록
부신생물 소뇌 퇴행증은 드물게 발생하는 부신생물 증후군 중 하나로 주로 폐, 난소, 유방암 등에서 일어나나, 종양의 전이나 직접 침윤에 의하여 일어나지는 않는 자가면역 과정에 의해 소뇌피질의 Purkinje 세포들이 이차적으로 손상된 질환이다. 저 자 등은 난소암 수술 7개월 후 아급성으로 발생한 부신생물 소뇌 퇴행증이 있어 보고하는 바이다. 부신생물 소뇌 퇴행증은 드물게 보고되고 있지만, 항암치료에 반응하는 난소암 환자에서 항-Yo항체가 있는 부신생물 소뇌퇴행증은 국내에 아직 보고 되지 않아 간단한 문헌고찰과 함께 보고하는 바이다.
Abstract
Paraneoplastic cerebellar degeneration (PCD), the one of rare paraneoplastic syndromes, refer to clinical disorders associated mostly with lung, ovarian and breast cancer, but not directly caused by cancer or its metastasis. PCD is a condition whereby the Purkinje cells of the cerebellar cortex are damaged secondary to an autoimmune process. We report here on the case of PCD of subacute onset in a patient at 7 months after surgery for ovarian cancer. Although the cases of PCD has rarely been reported, the present case appears to be the first in Korea in which PCD was associated with anti-Yo antibody in patient with chemotherapy-responsive ovarian cancer. The clinical significance of PCD associated with anti-Yo antibody is reviewed.
참고문헌 (16)
- Voltz R, "Paraneoplatic neurologic syndromes: an update on diagnosis, pathogenesis, and therapy", Lancet Neurol, 1, pp.294~305 (2002)
- Liu S, "Paraneoplastic cerebellar degeneration as the first evidence of cancer: a case report", Arch Phys Med Rehabil, 81, pp.834~836 (2000)
- Posner JB, "Paraneoplastic syndromes", Neurol Clin, 9, pp.919~936 (1991)
- Phuphanich S, "Neurologic improvement after high-dose intravenous immunoglobulin therapy in patients with paraneoplastic cerebellar degeneration associated with anti-Purkinje cell antibody", J Neurooncol, 81, pp.67~69 (2007)
- Santillan A, "Paraneoplastic cerebellar degeneration in a woman with ovarian cancer", Nat Clin Pract Oncol, 3, pp.108~112 (2006)
- Singh V, "Marantic endocarditis (NBTE) with systemic emboli and paraneoplastic cerebellar degeneration: uncommon presentation of ovarian cancer", J Neurooncol, 83, pp.81~83 (2007)
- Rojas I, "Long-term clinical outcome of paraneoplastic cerebellar degeneration and anti-Yo antibodies", Neurology, 55, pp.713~715 (2000)
- Giannopoulou C, "Navigating the paraneoplastic neurological syndromes", Eur J Nucl Med Mol Imaging, 30, pp.333~338 (2003)
- Marchand V, "A rare gynecological case of paraneoplastic cerebellar degeneration discovered by FDG-PET", Gynecol Oncol, 105, pp.545~547 (2007)
- Rupasinghe J, "Progressive ataxic gait disorder", J Clin Neurosci, 14, pp.153~157 (2007)
- Storstein A, "Autopsy findings in the nervous system and ovarian tumour of two patients with paraneoplastic cerebellar degeneration", Acta Neurol Scand Suppl, 183, pp.69~70 (2006)
- Monstad SE, "Yo antibodies in ovarian and breast cancer patients detected by a sensitive immunoprecipitation technique", Clin Exp Immunol, 144, pp.53~58 (2006)
- Greenlee JE, "Association of anti-Yo (type 1) antibody with paraneoplastic cerebellar degeneration in the setting of transitional cell carcinoma of the bladder: detection of Yo antigen in tumor tissue and fall in antibody titers following tumor removal", Ann Neurol, 45, pp.805~809 (1999)
- Drlicek M, "Antibodies of the anti-Yo and anti-Ri type in the absence of paraneoplastic neurological syndromes: a long-term survey of ovarian cancer patients", J Neurol, 244, pp.85~89 (1997)
- Cher LM, "Therapy for paraneoplastic neurologic syndromes in six patients with protein A column immunoabsorption", Cancer, 75, pp.1678~1683 (1995)
- Widdess-Walsh P, "Response to intravenous immunoglobulin in anti-Yo associated paraneoplastic cerebellar degeneration: case report and review of the literature", J Neurooncol, 63, pp.187~190 (2003)