알츠하이머병 환자의 말초혈액 내 CD34 양성세포 수치의 변화
Analysis of Circulating CD34-positive Cells in Alzheimer’s Disease
0
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Background: Circulating CD34-positive cells constitute the endothelial progenitor cell population,differentiate into endothelial cells, and contribute to mammalian brain regeneration. Given the vascular endothelial pathogenesis of Alzheimer’s disease (AD), we investigated the levels of CD34+ cells in AD patients. Methods: Sixty-six consecutive patients with probable AD (clinical dementia rating scale 1) and 22 age-matched control subjects were enrolled. CD34+cells were counted in their peripheral blood samples and analyzed in comparison with their clinical characteristics. Results: The AD patients had significantly lower numbers of CD34-positive cells than control subjects. However, the number of CD34-positive cells was not correlated with clinical characteristics of AD patients, including Mini Mental State Examination (MMSE)score, Framingham risk score, body-mass index, and changes in MMSE during 3 months. Conclusions: AD patients have diminished circulating CD34-positive cells, suggesting the reduced regenerative support from the peripheral blood in AD patients.
Abstract
Background: Circulating CD34-positive cells constitute the endothelial progenitor cell population,differentiate into endothelial cells, and contribute to mammalian brain regeneration. Given the vascular endothelial pathogenesis of Alzheimer’s disease (AD), we investigated the levels of CD34+ cells in AD patients. Methods: Sixty-six consecutive patients with probable AD (clinical dementia rating scale 1) and 22 age-matched control subjects were enrolled. CD34+cells were counted in their peripheral blood samples and analyzed in comparison with their clinical characteristics. Results: The AD patients had significantly lower numbers of CD34-positive cells than control subjects. However, the number of CD34-positive cells was not correlated with clinical characteristics of AD patients, including Mini Mental State Examination (MMSE)score, Framingham risk score, body-mass index, and changes in MMSE during 3 months. Conclusions: AD patients have diminished circulating CD34-positive cells, suggesting the reduced regenerative support from the peripheral blood in AD patients.
참고문헌 (20)
- Benarroch EE, "Neurovascular unit dysfunction: a vascular component of Alzheimer disease?", Neurology, 68, pp.1730~1732 (2007)
- Zlokovic BV, "Neurovascular mechanisms of Alzheimer’s neurodegeneration", Trends Neurosci, 28, pp.202~208 (2005)
- Weller RO, "Perivascular drainage of amyloid-beta peptides from the brain and its failure in cerebral amyloid angiopathy and Alzheimer’s disease", Brain Pathol, 18, pp.253~266 (2008)
- 이순태, "Decreased Vasomotor Reactivity in Alzheimer’s Disease", Journal of Clinical Neurology, 3(1), pp.18~23 (2007), 대한신경과학회
- Breteler MM, "Vascular risk factors for Alzheimer’s disease: an epidemiologic perspective", Neurobiol Aging, 21, pp.153~160 (2000)
- Hristov M, "Endothelial progenitor cells: mobilization, differentiation, and homing", Arterioscler Thromb Vasc Biol, 23, pp.1185~1189 (2003)
- Asahara T, "Isolation of putative progenitor endothelial cells for angiogenesis", Science, 275, pp.964~967 (1997)
- Mezey E, "Turning blood into brain: cells bearing neuronal antigens generated in vivo from bone marrow", Science, 290, pp.1779~1782 (2000)
- Cogle CR, "Bone marrow transdifferentiation in brain after transplantation: a retrospective study", Lancet, 363, pp.1432~1437 (2004)
- Maler JM, "Decreased circulating cd34(+) stem cells in early alzheimer’s disease: Evidence for a deficient hematopoietic brain support?", Mol Psychiatry, 11, pp.1113~1115 (2006)
- Taguchi A, "Circulating CD34-positive cells provide a marker of vascular risk associated with cognitive impairment", J Cereb Blood Flow Metab, 28, pp.445~449 (2008)
- Stellos K, "Increased circulating progenitor cells in Alzheimer’s disease patients with moderate to severe dementia: evidence for vascular repair and tissue regeneration?", J Alzheimers Dis, 19, pp.591~600 (2010)
- Lee ST, "Reduced circulating angiogenic cells in Alzheimer disease", Neurology, 72, pp.1858~1863 (2009)
- McKhann G, "Clinical diagnosis of Alzheimer’s disease: report of the NINCDSADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s Disease", Neurology, 34, pp.939~944 (1984)
- Schmidt-Lucke C, "Reduced number of circulating endothelial progenitor cells predicts future cardiovascular events: proof of concept for the clinical importance of endogenous vascular repair", Circulation, 111, pp.2981~2987 (2005)
- Kang HJ, "Effects of intracoronary infusion of peripheral blood stem-cells mobilised with granulocyte-colony stimulating factor on left ventricular systolic function and restenosis after coronary stenting in myocardial infarction: the MAGIC cell randomised clinical trial", Lancet, 363, pp.751~756 (2004)
- Taguchi A, "Circulating CD34-positive cells provide an index of cerebrovascular function", Circulation, 109, pp.2972~2975 (2004)
- Thum T, "Age-dependent impairment of endothelial progenitor cells is corrected by growth-hormone-mediated increase of insulin-like growth-factor-1", Circ Res, 100, pp.434~443 (2007)
- Dimmeler S, "HMG-CoA reductase inhibitors (statins) increase endothelial progenitor cells via the PI 3-kinase", Akt pathway, 2001, pp.108, 391~397
- Song IU, "Clinical significance of silent cerebral infarctions in patients with Alzheimer disease", Cogn Behav Neurol, 20, pp.93~98 (2007)