기억성 경도인지장애와 초기 알쯔하이머병에서의 국소뇌혈류 변화

Abstract

Background: Amnestic mild cognitive impairment (aMCI) is an intermediary state between normal aging and Alzheimer’s disease (AD). Previous studies showed most of the aMCI patients have histopathologic changes compatible with AD. We studied patterns of regional cerebral blood flow (rCBF) in aMCI and early AD with statistical parametric mapping (SPM) analysis of 99mTc-ECD single photon emission computed tomography (SPECT) to estimate the functional abnormality in two groups. Methods: Eighteen subjects with early AD (male 7, female 11, age 69.60±76.78) and sixteen subjects with aMCI (male 6, female 10, age 69.19±7.13) were recruited. ECD-SPECT was performed in two groups and 14 age-matched normal controls and SPM analysis was conducted to identify brain regions with decreased rCBF in each groups. Results: Significantly decreased rCBF was observed in left inferior temporal, thalamus, superior temporal, and bilateral prefrontal and parietal areas in aMCI group compared to normal controls. In the early AD group, similar patterns of decreased rCBF were observed. Early AD group had more decreased rCBF in the left superior prefrontal area compared to aMCI group. Conclusions: Although aMCI is an intermediary state between normal aging and AD, cerebral function measured by rCBF in aMCI was already decreased to the similar extent of early AD. Early AD group had more decreased rCBF in the superior prefrontal area, which is probably associated with impairment in the activities of daily living.