스마트팜 재배 땅콩새싹 추출물의 피부 보습, 장벽 강화 및 재생 효과
Skin moisturizing, barrier-enhancing, and regenerative effects of smart farm-cultivated peanut sprout extracts
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Peanut sprouts, derived from germinating peanuts (Arachis hypogaea L.), are rich in bioactive compounds with health-promoting effects, including antioxidant, anti-inflammatory, and anti-obesity activities. In this study, peanut sprouts were cultivated in a smart farm, and extracts were prepared using water, 50% ethanol, and absolute ethanol to assess their phytochemical contents and skin-beneficial properties. The absolute ethanol extract exhibited the highest total polyphenol and flavonoid contents (78.06 mg/g and 6.54 mg/g, respectively), while LC-MS/MS analysis revealed that the 50% ethanol extract contained the highest levels of resveratrol (4.71 μg/g) and polydatin (3.14 μg/g). All extracts were non-cytotoxic to HaCaT cells. The 50% and absolute ethanol extracts upregulated hyaluronic acid synthase-2 (HAS-2), while HAS-3 expression remained unaffected. They also increased filaggrin and involucrin expression, indicating enhanced skin moisturization and barrier function. Moreover, these extracts significantly accelerated wound closure, demonstrating potent skin-regenerative effects. Therefore, these findings suggest that peanut sprout extracts are promising candidates for functional cosmetic applications.
Abstract
Peanut sprouts, derived from germinating peanuts (Arachis hypogaea L.), are rich in bioactive compounds with health-promoting effects, including antioxidant, anti-inflammatory, and anti-obesity activities. In this study, peanut sprouts were cultivated in a smart farm, and extracts were prepared using water, 50% ethanol, and absolute ethanol to assess their phytochemical contents and skin-beneficial properties. The absolute ethanol extract exhibited the highest total polyphenol and flavonoid contents (78.06 mg/g and 6.54 mg/g, respectively), while LC-MS/MS analysis revealed that the 50% ethanol extract contained the highest levels of resveratrol (4.71 μg/g) and polydatin (3.14 μg/g). All extracts were non-cytotoxic to HaCaT cells. The 50% and absolute ethanol extracts upregulated hyaluronic acid synthase-2 (HAS-2), while HAS-3 expression remained unaffected. They also increased filaggrin and involucrin expression, indicating enhanced skin moisturization and barrier function. Moreover, these extracts significantly accelerated wound closure, demonstrating potent skin-regenerative effects. Therefore, these findings suggest that peanut sprout extracts are promising candidates for functional cosmetic applications.