관절염 유발 동물 모델에서 이소에고마케톤 함유 패치의 관절염 치료 효과
The Therapeutic Effect of Medical Patches Including Isoegomaketone on the Collagen Antibody-induced Arthritis in Mice
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This study identified effects of Isoegomaketone for applicable patch on the arthritis in mice. Isoegomaketone (IK) was isolated from Perilla frutescens, which is annual herbal traditional medicinal,aromatic, functional food. IK has various physiological effects such as anti-inflammation, anti-oxidant,and anti-cancer. In the previous study, oral administration of IK to a mouse model of collagen antibodyinducedarthritis (CAIA), which is similar to human rheumatoid arthritis (RA), alleviated symptoms. In thisstudy, we attached a patch containing IK to mouse skin to demonstrate whether it had the same efficacyas oral administration in CAIA mouse. As a result of measuring the arthritis score, paw volume, andpaw thickness, it was confirmed that arthritis symptoms were alleviated in the group to which the patchcontaining IK was attached. These results show that IK is effective in alleviating arthritis not only throughoral administration but also through patches applied to skin, and that it has potential as a material forfuture patch development.
Abstract
This study identified effects of Isoegomaketone for applicable patch on the arthritis in mice. Isoegomaketone (IK) was isolated from Perilla frutescens, which is annual herbal traditional medicinal,aromatic, functional food. IK has various physiological effects such as anti-inflammation, anti-oxidant,and anti-cancer. In the previous study, oral administration of IK to a mouse model of collagen antibodyinducedarthritis (CAIA), which is similar to human rheumatoid arthritis (RA), alleviated symptoms. In thisstudy, we attached a patch containing IK to mouse skin to demonstrate whether it had the same efficacyas oral administration in CAIA mouse. As a result of measuring the arthritis score, paw volume, andpaw thickness, it was confirmed that arthritis symptoms were alleviated in the group to which the patchcontaining IK was attached. These results show that IK is effective in alleviating arthritis not only throughoral administration but also through patches applied to skin, and that it has potential as a material forfuture patch development.
참고문헌 (19)
- Linlin Chen, "Inflammatory responses and inflammation-associated diseases in organs", Oncotarget, 9(6), pp.7204~7218 (2017), Impact Journals, LLC[DOI]
- Furman D, "Chron"ic inflammation in the etiology of disease across the life span", Nat. Med, 25(12), pp.1822~1832 (2019)[DOI]
- Guo Q, "Rheu"matoid arthritis : pathological mechanisms and modern pharmaco"logic therapies", Bone Res, 6, pp.15~ (2018)[DOI]
- Kim HA, "The Management of arthritis", J. Korean Med. Assoc, 50(8), pp.743~750 (2007)[DOI]
- Meier FMP, "Current immunotherapy in rheumatoid arthritis", Immunotherapy, 3(9), pp.955~974 (2013)[DOI]
- 박선주, "국내 한방 패치 특허 현황에 대한 분석연구", 대한예방한의학회지, 22(1), pp.45~59 (2018), 대한예방한의학회[DOI]
- Zhang Y, "Design and eval"uation of a novel transdermal patch containing diclofenac and teriflunomide for rheumatoid arthritis therapy", Asian J. Pharm. Sci, 9(5), pp.251~259 (2014)[DOI]
- Pan SY, "New perspectives on how to discover drugs from herbal medicines : CAM’s Out"standing Contribution to Modern Therapeutics", Evid. Based Com"Plement. Alternat. Med, 2013, pp.627375~ (2013)[DOI]
- Gordaliza M, "Terpenyl-purines from the sea", Mar. Drugs, 7(4), pp.833~849 (2009)[DOI]
- 강시용, "한국 돌연변이육종 연구의 역사와 주요 성과 및 전망", 한국육종학회지, 52, pp.49~57 (2020), 한국육종학회[DOI]
- Dhyani A, "A review on nutritional value, functional properties and pharmacological application of Perilla(Perilla frutescens L.)", Biomed. Pharmacol. J, 12(2), pp.649~660 (2019)[DOI]
- Ahmed HM, "Ethnomedicinal, phytochemical and pharma"cological investigations of Perilla frutescens(L)", Britt. Molecules, 24(1), pp.102~ (2019)[DOI]
- Nam BM, "A new monoterpene from the leaves of a radiation mutant cultivar of Perilla frutescens var. crispa with inhibitory activity on LPS-induced NO production", Molecules, 22(9), pp.1471~ (2017)[DOI]
- Chang Hyun Jin, "Isoegomaketone Inhibits Lipopolysaccharide-Induced Nitric Oxide Production in RAW 264.7 Macrophages through the Heme Oxygenase-1 Induction and Inhibition of the Interferon-β-STAT-1 Pathway", Journal of Agricultural and Food Chemistry, 58(2), pp.860~867 (2010), American Chemical Society (ACS)[DOI]
- Jin CH, "Isoegoma"ketone alleviates the development of collagen antibody-induced arthritis in male BALB", c mice, 2017, pp.22(7), 1209~
- 김송희, "백출(白朮)의 콜라겐 유도 관절염 마우스에서의 관절염 개선 효과 연구", 대한본초학회지, 27(3), pp.1~6 (2012), 대한본초학회
- Kristine LS, "A highly selective, orally active inhibitor of Janus kinase 2, CEP-33779, ablates disease in two mouse models of rheuma"toid arthritis", Arthritis Res. Ther, 13(2), pp.R68~ (2011)[DOI]
- Perilli E, "Quantifying not only bone loss, but also soft tissue swelling in a murine inflammatory arthritis model using micro-computed tomography", Scand. J. Immunol, 81(2), pp.142~150 (2014)[DOI]
- Quan P, "Alternative therapy of rheumatoid arthritis with a novel transdermal patch containing Siegesbeckiae Herba extract", J. Ethnopharmacol, 265, pp.113294~ (2021)[DOI]