추출조건에 따른 참돌꽃의 면역 활성
Immune Activities of Rhodiola sachalinensis A. Bor Extracts Isolated with Various Extraction Process
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초록
This study was performed to compare effect of immune activities of Rhodiola sachalinensis by various extraction process with different temperature and extraction solvents. Experiments were performed for investigate the immune activities on human B and T cell growth and secretion of their cytokines. Also, antibodies in serum were investigated in female ICR mouse by feeding the extracts of R. sachalinensis at doses of 40, 120 and 360 ㎎/㎏ orally for 15 days. The immune cell growth and secretion of cytokines (IL-6, TNF-α) on human B and T cells were increased by adding R. sachalinensis extracts compare to the control. Also, total serum IgG levels increased by feeding R. sachalinensis extracts. It can be conclude that optimum condition for efficient extraction of R. sachalinensis as functional material is slovent extraction process using water with ultrasonification at below 100℃ than typical process.
Abstract
This study was performed to compare effect of immune activities of Rhodiola sachalinensis by various extraction process with different temperature and extraction solvents. Experiments were performed for investigate the immune activities on human B and T cell growth and secretion of their cytokines. Also, antibodies in serum were investigated in female ICR mouse by feeding the extracts of R. sachalinensis at doses of 40, 120 and 360 ㎎/㎏ orally for 15 days. The immune cell growth and secretion of cytokines (IL-6, TNF-α) on human B and T cells were increased by adding R. sachalinensis extracts compare to the control. Also, total serum IgG levels increased by feeding R. sachalinensis extracts. It can be conclude that optimum condition for efficient extraction of R. sachalinensis as functional material is slovent extraction process using water with ultrasonification at below 100℃ than typical process.
참고문헌 (22)
- Abo T, "Immunologic states of autoimmune diseases", Immunologic Research, 33, pp.23~34 (2005)
- Afanas’ev SA, "Participation of inducible stress proteins in the cardioprotective effect of Rhodiolae rosea", Biochemistry (Moscow), 61, pp.1258~1263 (1996)
- 최승필, "홍경천 추출물의 항산화성, 항돌연변이성 및 세포독성 효과", 한국식품영양과학회지, 32(2), pp.211~216 (2003), 한국식품영양과학회
- Doll R, "The causes of cancer : quantitative estimates of avoidable risks of cancer in the United States today", Journal of the National Cancer Institute, 66, pp.191~308 (1983)
- Ganzler K, "Microwave extraction. A novel sample preparation method for chromatography", Journal of Chromatography A, 371, pp.299~306 (1987)
- Han BH, "Effect of Ginsenosides from Panax ginseng on TNF-α production and T cell proliferation", Yakhak Hoeji, 42, pp.296~301 (1998)
- Ip SP, "Association of free radicals and the tissue renin-angiotensin system: prospective effects of Rhodiola, a genus of Chinese herb, on hypoxia-induced pancreatic injury", Journal of the Pancreas, 2, pp.16~25 (2001)
- Kelly GS, "Rhodiola rosea: a possible plant adaptogen", Alternative Medicine Review, 6, pp.293~302 (2001)
- 이현용, "저온 추출 공정에 의한 마황과 복분자의 면역 활성 증진 효과", 한국약용작물학회지, 13(3), pp.81~86 (2005), 한국약용작물학회
- Kim JH, "Effects of the aqueous extract of Epimedii herba on the antibody responses in mice", International Immunopharmacology, 1, pp.935~944 (2001)
- Kwon JH, "High speed extraction of phytochemicals from food and natural products using microwave-assisted process", Food Science and Industry, 31, pp.43~55 (1998)
- 권민철, "초음파 추출물을 이용한 치콘의 면역활성 증진", 한국약용작물학회지, 16(1), pp.9~15 (2008), 한국약용작물학회
- 권민철, "강화 사자발쑥의 항암활성 증진을 위한 추출조건의 최적화", 한국약용작물학회지, 15(4), pp.233~240 (2007), 한국약용작물학회
- Lee MK, "Enhancement immune activity and cytotoxicity of Artemisia capillaris Thunb. extracts against human cell lines", Korean Journal of Medicinal Crop Science, 12, pp.34~42 (2004)
- 이서호, "황칠나무 잎의 면역활성증진기능 탐색", 한국약용작물학회지, 10(2), pp.109~115 (2002), 한국약용작물학회
- Lee YK, "Normal values of IgG and IgG subclass concentrations according to age in children", Pediatric Allergy and Respiratory Disease, 9, pp.93~99 (1999)
- Lishmanov YB, "Opiatergic mechanisms of cardioprotective and antiarrhythmic effects of adaptation", Bulletin of Experimental Biology and Medicine, 127, pp.151~154 (1999)
- Lopez-Avila V, "Microwaveassisted extraction as an alternative to soxhlet,sonication,and supercritical fluid extraction", Journal of AOAC International, 79, pp.142~156 (1996)
- Majewska A, "Antiproliferative and antimitotic effect, S phase accumulation and induction of apoptosis and necrosis after treatment of extract from Rhodiola rosea rhizomes on HL-60 cells", of Ethnopharmacology, 103, pp.43~52 (2006)
- Petkov VD, "Effects of alcohol aqueous extract from Rhodiola rosea L. roots on learning and memory", ACTA Physiologica et Pharmacologica Bulgarica, 12, pp.3~16 (1986)
- Razina TG, "Medicinal herb preparations as a means of additional therapy:experimental oncology evidence", Eksperimentalnaia i klinicheskaia farmakologiia, 63, pp.59~61 (2000)
- Vinatoru M, "An overview of the ultrasonically assisted extraction of bioactive priciples from herbs", Ultrasonics Sonochemistry, 8, pp.303~313 (2001)