증숙 및 초고압 증숙 공정을 통한 더덕의 면역활성 증진
Enhancement of Immune Activity of the Extracts from Codonopsis lanceolata by Stepwise Steaming Process and High Pressure Process
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초록
This study was to investigate the improvement of immune activities of the extracts from Codonopsis lanceolataby stepwise steaming process and high pressure process. The phenol contents was 8.742㎍/㎎ which was higher thanthat from conventional extraction using 70% ethyl alcohol at 80℃ for 24 hours. All of extracts at a concentration of 1.0 ㎎/㎖showed relatively low cytotoxicity on human normal kidney cell (HEK293) in range of 16 19%. The immune B and T cellgrowth was improved by extracts using the steamed and high pressure precess of C. lanceolata up to 180 × 104 cells/㎖ and96 × 104 cells/㎖, respectively. The extract prepared also greatly increased the secretion of both IL-6 and TNF-α from thestepwise steamed and high pressure process. This results can conclude that stepwise steamed and high pressure processeffectively released active biomaterials which could important role in enhancing immune activity in the body.
Abstract
This study was to investigate the improvement of immune activities of the extracts from Codonopsis lanceolataby stepwise steaming process and high pressure process. The phenol contents was 8.742㎍/㎎ which was higher thanthat from conventional extraction using 70% ethyl alcohol at 80℃ for 24 hours. All of extracts at a concentration of 1.0 ㎎/㎖showed relatively low cytotoxicity on human normal kidney cell (HEK293) in range of 16 19%. The immune B and T cellgrowth was improved by extracts using the steamed and high pressure precess of C. lanceolata up to 180 × 104 cells/㎖ and96 × 104 cells/㎖, respectively. The extract prepared also greatly increased the secretion of both IL-6 and TNF-α from thestepwise steamed and high pressure process. This results can conclude that stepwise steamed and high pressure processeffectively released active biomaterials which could important role in enhancing immune activity in the body.
참고문헌 (18)
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