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消平湯이 Streptozotocin으로 유발된 당뇨쥐의 혈당 및 항산화 효소 활성에 미치는 영향

Effects of Sopyung-tang Extract on Blood Glucose & Antioxidant Enzyme Activities of Streptozotocin-induced Diabetic Rats

한동운|김철중|조충식|최정식|장선규
대한한방내과학회 (The Society Of Korean Oriental Internal Medicine)|2008.03|대한한방내과학회지 (The Journal of Korean Oriental Internal Medicine)|제29권 제1호|pp. 90-103

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참고문헌

키워드

Diabetes mellitusoxidative stressstreptozotocinSopyung-tang(SPT)insulin-immunoreactive granules
주제분류한의학

초록

Objective : This study wascarried out to understand the effect of Sopyung-tang (SPT) on blood glucose & antioxidant enzyme activities in streptozotocin-induced diabetic rats.Methods : SD rats were separated into three groups, each with 20 rats. Except the normal group, the other two groups were intra-peritoneally injected with streptozotocin 60㎎/㎏. The experimental group was treated with SPT extract 500㎎/㎏/day for 4 weeks. The normal and control groups were treated with saline 500㎎/㎏/day for 4 weeks.Changes of plasma glucose level and body weight were observed. After4 weeks, liver and kidney weight, antioxidant enzyme activities, and survival rate were observed with histological changes on liver, kidney and pancreas.Results : In the experimental group, body weight and survival rate increased, while plasma glucose level decreased significantly. Liver and kidney weight, XOD activity decreased in the experimental group compared to the control. GSH-px and CAT activities andinsulin-immunoreactive granules in β-cells increased significantly in the experimental group compared to the control.Conclusions : This study shows that SPT might be effective for treatment of diabetes and its complications, as well as reduction of oxidative stress.

Abstract

Objective : This study wascarried out to understand the effect of Sopyung-tang (SPT) on blood glucose & antioxidant enzyme activities in streptozotocin-induced diabetic rats.Methods : SD rats were separated into three groups, each with 20 rats. Except the normal group, the other two groups were intra-peritoneally injected with streptozotocin 60㎎/㎏. The experimental group was treated with SPT extract 500㎎/㎏/day for 4 weeks. The normal and control groups were treated with saline 500㎎/㎏/day for 4 weeks.Changes of plasma glucose level and body weight were observed. After4 weeks, liver and kidney weight, antioxidant enzyme activities, and survival rate were observed with histological changes on liver, kidney and pancreas.Results : In the experimental group, body weight and survival rate increased, while plasma glucose level decreased significantly. Liver and kidney weight, XOD activity decreased in the experimental group compared to the control. GSH-px and CAT activities andinsulin-immunoreactive granules in β-cells increased significantly in the experimental group compared to the control.Conclusions : This study shows that SPT might be effective for treatment of diabetes and its complications, as well as reduction of oxidative stress.

참고문헌 (49)

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