요통으로 한방치료중인 폐경 후 여성의 대사증후군 요인이 골밀도에 미치는 영향에 관한 연구
Study of Relationship between Metabolic Syndrome and Bone Mineral Density on Post Menopausal Chronic Low Back Pain Patients Under Oriental Medicine Treatment
1
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
This study was performed from April, 2007 to August, 2012 with female patients who were being treated for and suffering from chronic lumbar pain for periods of 6 months and over. The 53 female patients were diagnosed with osteoporosis by having a T-Score of <-2.5 in a bone mineral density(BMD), as well as showing signs of metabolic syndrome. This was deduced by taking measurements of blood pressure, carrying out blood-chemical examinations and physical measurements such as weight, height, waist measurement and body mass index(BMI). After 5 minutes rest, the patient’s blood pressure, height and weight were measured. BMI was calculated using the equation BMI = weight (Kg)/height (m2). The patients had their blood taken in a fasted state(more than 12hours), the fasting blood sugar, total cholesterol, triglyceride, HDL-cholesterol were measured. The average BMD and T-score were calculated by measuring BMD(mg/cc) of L1-L3 using QCT. In a correlation analysis of the physical examinations, clinical character of metabolic syndrome and T-score, the result showed that age and T-score had a negative correlation(r=-0.699, p<0.01) as did triglyceride and T-score (r=-0.047, p<0.01), where as weight(r=0.239, p<0.05) and height(r-=0.329, p<0.01) and T-score had a positive correlation. There was no significant correlation with total cholesterol, HDL cholesterol, blood sugar, blood pressure and T-score. This study showed that there are significant correlations with age, weight, height and T-score. But there are no significant correlations with total cholesterol, HDL cholesterol, blood sugar, blood pressure and T-score and that these did not influence bone density. Further research with more subjects is required to determine whether there is a correlation of clinical character of metabolic syndrome and T-score.
Abstract
This study was performed from April, 2007 to August, 2012 with female patients who were being treated for and suffering from chronic lumbar pain for periods of 6 months and over. The 53 female patients were diagnosed with osteoporosis by having a T-Score of <-2.5 in a bone mineral density(BMD), as well as showing signs of metabolic syndrome. This was deduced by taking measurements of blood pressure, carrying out blood-chemical examinations and physical measurements such as weight, height, waist measurement and body mass index(BMI). After 5 minutes rest, the patient’s blood pressure, height and weight were measured. BMI was calculated using the equation BMI = weight (Kg)/height (m2). The patients had their blood taken in a fasted state(more than 12hours), the fasting blood sugar, total cholesterol, triglyceride, HDL-cholesterol were measured. The average BMD and T-score were calculated by measuring BMD(mg/cc) of L1-L3 using QCT. In a correlation analysis of the physical examinations, clinical character of metabolic syndrome and T-score, the result showed that age and T-score had a negative correlation(r=-0.699, p<0.01) as did triglyceride and T-score (r=-0.047, p<0.01), where as weight(r=0.239, p<0.05) and height(r-=0.329, p<0.01) and T-score had a positive correlation. There was no significant correlation with total cholesterol, HDL cholesterol, blood sugar, blood pressure and T-score. This study showed that there are significant correlations with age, weight, height and T-score. But there are no significant correlations with total cholesterol, HDL cholesterol, blood sugar, blood pressure and T-score and that these did not influence bone density. Further research with more subjects is required to determine whether there is a correlation of clinical character of metabolic syndrome and T-score.
참고문헌 (30)
- Korean Society of Bone Metabolism, "Physician's guide for diagnosis and treatment of osteoporosis" (2010), The Korean Society of Bone Metabolism
- Takuo Fujita, "Recent advances on osteoporosis", The Journal of Korean Society of Endocrinology, 5(2), pp.92~100 (1990)
- Consensus development conference, "diagnosis, prophylaxis and treatment of osteoporosis", Am J Med, 94, pp.646~650 (1993)
- Report of a WHO consultation of metabolic syndrome in definition, diagnosis, and classification of diabetes mellitus and its complications. I. Diagnosis and classification of diabetes mellitus, "WHO(World Health Organization)", World health Organization, Department of Noncommunicable Disease Surveillance, ~ (1999)
- 박혜순, "한국인에서의 대사증후군의 역학", 대한비만학회지, 11, pp.203~211 (2002)
- Executive Summary of the Third report of the National Cholesterol Education Program(NCEP) Expert Panel on Detection, "Evaluation, and treatment of high Blood cholesterol in Adults(Adult Treatment Pannel III)", JAMA, 28, pp.2486~2497 (2001)
- Baldini, V., "Cardiovascular disease and osteoporosis", Journal of Endocrinological Investigation, 28, pp.69~72 (2005)
- Yamaguchi T., "Plasma lipids and osteoporosis in postmenopausal women. a pilot study", J Am Geriatr Soc, 51, pp.1510~1511 (2003)
- Andrea Poli., "Plasma Low-Density Lipoprotein Cholesterol and Bone Mass Densitometry in Postmenopausal Women", Obstet Gynecol, 102, pp.922~926 (2003)
- Korea Centers for Disease Control and Prevention, "The Fourth Korea National Health and Nutrition Examination Survery (KNHANES IV-2)", Korea Centers for Disease Control and Prevention
- Ford, E. S., "Prevalence of the metabolic syndrome among US adults : findings from the third National Health and Nutrition Examination Survey", JAMA, 287, pp.356~359 (2002)
- Park, Y. W., "The metabolic syndrome: prevalence and associated risk factor findings in the US population from the Third National Health and Nutrition Examination Survey, 1988-1994", Arch Intern Med, 163, pp.427~436 (1994)
- Kim, S. M., "The effects of hormone therapy on metabolic risk factors in postmenopausal Korean women", Climacteric, 14, pp.66~74 (2011)
- NIH Consensus Development Panel, "Osteoporosis prevention, diagnosis, and therapy", JAMA, 285, pp.785~795 (2001)
- Cheil general hospital, "Claus Christiansen", The third symposium for osteoporosis in seoul, pp.43~45 (1995), Cheil general hospital
- Carranza Lira, S., "Osteoporosis in postmenopausal women(Mexico City): 1. risk factor. Int J Fertil", Women Med, 47(1), pp.22~25 (2002)
- 조수현, "폐경기 여성의 혈정 지질농도와 요추골밀도의 상관관계", 대한산부인과학회지, 37(6), pp.1175~1180 (1994)
- Ettinger, B, "Prevention of osteoporosis : Treatment of estradiol deficiency", Obstet Gynecol, 72, pp.125~ (1988)
- Schindler, A. E., "Conversion of androstendione to estron by human fat tissue", J Clin Endocrinol Metab, 35, pp.327~ (2001)
- Truscott, J. G., "Variation in lumbar spine and femoral neck bone mineral measured by dual energy x-ray absorption : a study of 329 normal women", Br J Rad, 66, pp.514~ (1993)
- Young, E. A, "Nutrition, aging and the aged", Med Clin North AM, 67, pp.295~ (1983)
- Lirani-Galvao, A. P. R., "Physical approach for prevention and treatment of osteoporosis", Arquivos Brasileiros de Endocrinol & Metabologia, 54(2), pp.171~178 (2010)
- Stolk, R. P., "Insulin, hypertension and antihypertensitive drugs in elderly patients", J. Hypertens, 14(2), pp.234~242 (1996)
- Perez-Castrillon, N. L., "Bone mass and bone modelling markers in hypertensive postmenopausal women", J Hum Hypertens, 17(2), pp.107~110 (2003)
- Larijani. B., "Bone mineral density is related to blood pressure in men", Am J Hum Biol, 16(2), pp.63~73 (2004)
- Grobbee, D. E., "Raised plasma intact parathyroid hormone concentrations in young people with mildly raised blood pressure", Br. Med J, 296(6625), pp.814~816 (1988)
- L. H. Cui., "Association between Bone Mineral Densities and Serum Lipid Profiles of Pre and Post-Menopausal Women in South Korea, Osteoporosis Int", Osteoporosis Int, 16, pp.1975~1981 (2005)
- D'Amelio, P., "High Density Lipoproteins(HDL) in Women with Postmenopausal Osteoporosis : A Preliminary Study", Menopause, 8, pp.429~432 (2001)
- Poli, A., "Plasma Low-Density Lipoprotein Cholesterol and Bone Mass Densitometry in Postmenopausal Women", Obster Gynecol, 102, pp.922~926 (2003)