폐경 후 여성에서 대사증후군과 골밀도의 연관성
Association of the Metabolic Syndrome and Bone Mineral Density in Postmenopausal Women
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연구배경: 대사증후군은 내당능장애, 이상지질혈증, 인슐린저항성, 고혈압, 복부비만과 같은 심혈관계 질환의 위험 인자가 군집되어 나타나는 증후군을 말한다. 대사증후군 위험 인자 들과 골다공증과의 연관성을 폭넓게 연구되어 왔으나 결과는 논란의 여지가 있다. 국내에서 아직까지 대사증후군 전체 위험인자들의 골밀도에 대한 복합적인 영향을 보고한 연구는 이루어지지 않고 있다. 따라서 본 연구에서는 대사증후군과 골밀도의 연관성을 규명하고자 한다. 방법: 2006년 11월 1일부터 2007년 10월 31일까지 일개 대학병원 건강증진센터를 방문한 폐경 후 여성들 중 353명을 대상으로 하였다. 대상자들의 생활습관과 현재병력은 자기 기입식 설문지를 통해 조사하였고, 신장, 체중, 허리둘레, 혈압, 혈당과 혈액지질을 측정하였다. 결과: 대사증후군의 유병률은 21.8%로 나타났다. 나이와 다른인자를 보정한 결과 대사증후군 위험인자 중 허리둘레만이대퇴골 및 요추 골밀도와 유의한 연관성을 보였다(P<0.05). 나이와 다른 인자들을 보정 하였을 때 대퇴골 골밀도와 요추의골밀도는 대사증후군 유무와는 관련이 없었다. 체질량지수에따른 층화분석에서 보정된 골밀도는 대사증후군 유무와 상관없이 의미있는 관련성을 보이지 않았다. 결론: 대사증후군이 있는 폐경 후 여성의 골밀도는 비만, 특히복부 비만에 의하여 영향을 받는다고 생각된다.
Abstract
Background: The metabolic syndrome (MS) is a cluster of risk factors of cardiovascular disease. The association between components of the MS and bone mineral density has been researched, but no prior studies have directly evaluated the association with the metabolic syndrome and bone mineral density in Korea. Methods: We evaluated postmenopausal women who had visited a university hospital from November 2006 to October 2007. Data on their lifestyle, current medical diseases and medications were collected from medical records. Height, body weight, waist circumference and serum lipid profi les were measured. Results: The prevalence of metabolic syndrome was 21.8% in this study. In adjusted analysis including age and other factors, only waist circumference had a close correlation with bone mineral density of femur and lumbar vertebral body (P < 0.05). The bone mineral density of femur and lumbar vertebral body had no correlation with the presence of metabolic syndrome. When stratifi ed by body mass index, corrected bone mineral density revealed no signifi cant correlation with the presence of metabolic syndrome. Conclusion: The bone mineral density of postmenopausal women with metabolic syndrome has highly influenced by obesity, especially by abdominal obesity.
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