대사증후군 진단요소를 통한 대사증후군과 골밀도와의 연관성 분석
The Association between Components of the Metabolic Syndrome and Bone Mineral Density
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연구목적: 대사증후군을 구성하는 진단요소들과 골밀도와의 연관성을 알아 보고자 한다. 연구방법: 본 연구는 고대구로병원 검진센터를 방문한 진료자 중 신체 계측치 (신장, 체중, 허리둘레, 혈압)와 혈액 검사(중성지방, high-density lipoprotein (HDL)-콜레스테롤, 공복 시 혈당), 골밀도 검사를 시행하고 설문지를 바탕으로 흡연, 음주, 운동, 폐경 유무, 약물 복용력 등의 건강력을 확인한 128명의 남성 (평균나이 50.4 ± 8.3세)과 391명의 여성 (평균나이 46.9 ± 11.6세)을 대상으로 후향적 단면 연구이다. 결 과: 여성의 경우, 대사증후군이 없는 정상군에 비해 대사증후군이 있는 경우 요추골 골밀도와 볼기뼈 골밀도 모두감소되어 있었으며, 나이, 신체질량지수, 폐경 여부, 음주력, 흡연력, 운동력으로 보정하여도 이 차이는 유지되었다 (각각평균 0.937 ± 0.136 g/㎠, P-value 0.010; 평균 0.875 ± 0.113 g/㎤, P-value 0.045). 그러나 남성은 보정 전 후 차이가 없었다 (각각 P-value 0.256, 0.672). 골밀도와 대사증후군 구성요소를 회귀분석 하였을 때, 여성에서는 허리둘레가 요추골골밀도와 볼기뼈 골밀도에 영향을 미쳤으나 (각각 β -0.003, P-value < 0.001; β -0.001, P-value 0.001) 남성에서는 의미 있는요소가 없었다. 결 론: 남성은 대사증후군의 어떤 요소도 골밀도와 관련이 없었으나, 여성은 허리둘레가 골밀도와 관련이 있었다. 여성의 경우, 대사증후군이 없는 정상군에 비해 대사증후군이 있는 경우 골밀도가 감소하였다.
Abstract
Objective: The aim of this study was to evaluate the association between the components of the metabolic syndrome (MS) and bone mineral density (BMD). Methods: We conducted a retrospective cross-sectional analysis for 128 men (mean age 50.4 ± 8.3 years) and 391women (mean age 46.9 ± 11.6 years) in Korea University Guro Hospital, Korea. Height (cm), weight (kg), waist circumference (cm), and blood pressure (mmHg) were measured. Fasting plasma glucose (FPG), high-density lipoprotein cholesterol (HDL-C), and triglycerides were measured. BMD at the total hip and lumbar spine was measured by dual X-ray densitometry. All participants completed a standardized questionnaire including medical history, smoking history, alcohol consumption, physical activity and menopausal status. Results: Women with MS had lower BMD at lumbar and total hip sites (0.937 ± 0.136 g/㎠, P-value 0.010; 0.875± 0.113 g/㎠, P-value 0.045, respectively) than did women without MS. These differences at the spine and femoral neck were persisted after adjusting for age, body mass index, menopause status, alcohol consumption, smoking and physical activity. However, no significant differences in BMD were found in men between those with and without MS. In linear regression analyses, waist circumferences were highly associated with BMD at lumbar and total hip sites in women (β -0.003, P-value < 0.001; β -0.001, P-value 0.001, respectively). However, no significant differences were found in men between BMD and components of the MS. Conclusion: Among components of MS, waist circumference was associated with BMD in women. But no association was found in men. Women with MS had lower BMD than did women without MS. [Korean Journal of Bone Metabolism, 18(1): 55-64, 2011]
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