건강한 한국 성인에서 비타민 D 농도와 내장지방면적의 상관관계
Association between Vitamin D Concentration and Visceral Fat Area in Healthy Korean Adults
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연구배경: 비타민 D와 내장지방의 상관관계에 대한 연구가 활발히 이루어지고 있으나, 국내 연구는 많지 않은 실정이다. 본 연구는 건강한 한국인 성인에서 혈청 비타민 D 농도와 생체 전기 저항 측정법으로 측정한 내장지방면적사이의 연관성에 대해 알아보고자 하였다. 방법: 본 단면연구는 건강증진센터를 방문한 20-70세의1,945명의 성인을 대상자로 하였다. 모든 대상자에서 생체전기 저항 측정법으로 내장지방면적을 추정하고, 화학발광면역 분석법으로 혈청 25-hydroxyvitamin D (25[OH]D) 농도를 측정하였다. 다중회귀분석을 시행하여 내장지방면적과 혈청 25(OH)D의 독립적인 상관관계를 확인하였다. 결과: 비타민 D 결핍(25[OH]D: 20-29 ng/mL)과 부족(25[OH]D <20 ng/mL)의 유병률은 각각 54.4%와 38.1%였다. 나이와 계절을 보정한 후, 내장지방면적은 남성(P<0.001) 및 여성(P<0.001)에서 혈청 25(OH)D 농도와 음의 상관관계를 보였다. 결론: 건강한 한국인 성인에서 생체 전기 저항 측정법으로 측정한 내장지방면적과 혈청 25(OH)D 농도는 음의 상관관계를 보였다.
Abstract
Background:Studies on the relationship between vitamin D and visceral fat area (VFA; intra-abdominal fat area) have been actively conducted. But, there is a few Korean population-based studies about the association between serum vitamin D level and VFA. The aim of our study was to explore the correlation between serum 25-hydroxyvitamin D (25[OH]D) levels and VFA measured using bioelectrical impedance analysis (BIA; electric impedance) in healthy Korean adults. Methods:This cross-sectional study involved 1,945 adults aged 20-70 years who visited a health promotion center. All subjects underwent the BIA to estimate the VFA. Serum 25(OH)D level was measured using chemiluminescent immunoassay. Multiple regression analysis was performed to identify independent correlation of VFA and serum 25(OH)D level. Results:The prevalence of vitamin D deficiency (25[OH]D: 20-29 ng/mL) and insufficiency (25[OH]D <20 ng/mL) were 54.4% and 38.1%, respectively. After having adjusted age and season, VFA were negatively associated with serum 25(OH)D levels in both men (P<0.001) and women (P<0.001). The obese group with VFA ≥ 100 cm 2 had significant lower serum 25(OH)D level in men (P<0.001) and women (P=0.0034). Conclusions:VFA measured using BIA could be negatively associated with serum 25(OH)D levels in healthy Korean adult.
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