부천 지역 폐경 전후 여성의 인유두종바이러스 감염 유병율
Prevalence of Human Papilloma Virus Infection in Perimenopausal Women in Bucheon Province
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연구목적: 부천 지역에 거주하는 폐경 전후의 여성들의 HPV 아형 분포와 HPV 유병률을 자궁경부 세포진 검사 및 조직검사의 결과와 비교하여 그 관련성을 알고자 하였다. 연구재료 및 방법: 2011년 1월부터 3월까지 본 병원 산부인과 외래에서 자궁경부 세포진 검사 (thinprep pap test)와 HPV DNA chip test를 동시에 시행한 환자 280명의 여성 (연령의 평균값은 41.9세, 범위 21∼90세)을 대상으로 하였다. 결과: 이번 연구에 포함된 여성 전체 HPV 유병률은 33.9% (95/280)이었다. 폐경 후 여성의 HPV 유병률은 24.3% (17/70)로 폐경 전 여성 (37.1%)에 비하여 통계적으로 유의하게 낮았다 (P = 0.049). 결론: 부천 지역에 거주하는 폐경 후 여성의 HPV 유병률은 24.3%로 추산된다. 폐경 전 여성과 비교해서는 낮은 유병률이지만 HPV 감염 자체가 폐경 여성에게서는 자궁경부암이나 자궁경부 상피 내 암종을 유발할 가능성이 크기 때문에 중요하다. 이번 연구를 기초로 향후 더 많은 폐경 후 여성을 면밀히 추적 관찰하며, 전향적 연구를 통한 역학적인 연구가 더 이루어져야 할 것으로 생각된다.
Abstract
Objectives: To investigate the prevalence of human papillomavirus (HPV) infection in Bucheon province. Methods: Two hundred eighty Korean women (average age 41.9, range 21∼90 years) were enrolled, who received a regular thinprep pap test and an HPV deoxyribonucleic acid (DNA) chip test simultaneously at Soonchunhyang University Hospital, Bucheon, from February 2011 to March 2011. Results: The overall prevalence of HPV infection was 33.9% (95/280). The prevalence of HPV infection in postmenopausal women (24.3%) was significantly lower than that of premenopausal women (37.1%, P = 0.049). Conclusion: Although the prevalence of HPV infection in postmenopausal women was lower than that of premenopausal women, HPV infection is more critical in postmenopausal women as HPV infection in postmenopausal women is more likely to induce cervical cancer than in premenopausal women.
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