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한국여성에서 자궁경부암의 고위험군 인유두종바이러스의 동정

Identification of High Risk Group of HPV associatedwith Cervical Cancer in Korean Women

이방현|윤효진|이상희|박민혜|권혁찬|임정애|이병관
대한산부인과학회 (Korean Soceity of Obstetrics and Gynecology)|2004.12|Obstetrics & Gynecology Science|제47권 제12호

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참고문헌

키워드

HPV-DNA testHPV-genotyping고위험군 HPVHigh risk group of HPV
주제분류산부인과학

초록

목적 : 한국 여성에서 자궁경부암과 관련되어 발현되는 하부생식기 HPV 형과 자궁경부암의 고위험군 HPV 형을 분류하고자 한다. 연구 방법 : 본원에서 자궁경부암 검사를 시행하는 환자들을 대상으로 Pap test와 PCR 방법에 의한 HPV- DNA 검사를 시행하였고 HPV-DNA 검사에서 양성으로 판명된 경우 sequencing 방법에 의한 HPV-genotyping과 자궁경부 조직검사를 시행하였다. 결과 : HPV 감염의 주된 연령군은 40대였고 (34.3%) 유병률은 9.8%였으며 총 23형의 HPV 형이 동정되었다. 침윤성 자궁경부암에서는 HPV 16와 58이 동정되었고 HSIL에서는 HPV 16, 31, 33, 45 및 58이 동정되었으며 LSIL에서는 HPV 6, 11, 18, 53, 59 및 66이 동정되었다. HPV 16이 HSIL과 침윤성 자궁경부암에서 가장 많이 발현된 고위험군 HPV였다.

Abstract

Objective : To identify genital HPV types and high risk group of HPV associated with cervical cancer in Korean women. Methods : Both Pap test and HPV-DNA test using PCR assay were performed as screening test for cervical cancer in this clinic. When patients were positive in HPV-DNA test, HPV genotyping using sequencing method and cervical biopsy were performed. Results : Frequent age group of HPV infection was 40 yrs (34.3%) and prevalence of HPV infection was 9.8%. Twenty-three types of HPV were detected. HPV 16 and 58 were detected in invasive cancer. HPV 16, 31, 33, 45, and 58 were detected in HSIL. HPV 6, 11, 18, 53, 59, and 66 were detected in LSIL. HPV 16 was most commonly detected in HSIL and invasive cancer. Conclusion : HPV 16, 31, 33, 45, and 58 are included in high risk group of HPV in Korean women. It may be very effective in early detection of cervical cancer to classify HPV types included in high risk group of cervical cancer in Korean women and to perform cervical biopsy in the patients who have high risk types of HPV infection.

참고문헌 (43)

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