국내 광주, 전남 지역에서 비정상적인 자궁경부 표본과연관된 인 유두종 바이러스의 유전자형 분석
Genotype Analysis of Human Papilloma Virus Infection Associated with Abnormal Cervical Tissues in Gwangju and Jeonnam, Korea
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Objectives: This study investigated the association between genotypes of human papilloma virus (HPV) infection and development of cervical abnormalities in patients in Gwangju and Jeonnam, Korea. Methods: Cross-sectional study was performed using HPV DNA chip test (7,818 samples) and histological analysis of obstetrics patients in Gwangju and Jeonnam, Korea. Single and multiple HPV infections were analyzed in patients with cervical intraepithelial neoplasia and cervical cancer. Results: Prevalence of HPV peaked in women 10s-20 years of age, decreased in women 30 years of age, and increased in women 60 years of age in Gwangju and Jeonnam, Korea. One of the most interesting results of the histological diagnosis showed that genotype distribution in the high-risk group increased with high-risk lesions. These results do not mean that multiple infections are more dangerous but may be an important factor in specific high-risk HPV genotypes. Conclusions: The prevalent HPV genotypes were HPV 16, 58, 18, 33, and 52 in the histological analysis
Abstract
Objectives: This study investigated the association between genotypes of human papilloma virus (HPV)infection and development of cervical abnormalities in patients in Gwangju and Jeonnam, Korea. Methods: Cross-sectional study was performed using HPV DNA chip test (7,818 samples) and histologicalanalysis of obstetrics patients in Gwangju and Jeonnam, Korea. Single and multiple HPV infections wereanalyzed in patients with cervical intraepithelial neoplasia and cervical cancer. Results: Prevalence of HPV peaked in women 10s-20 years of age, decreased in women 30 years of age,and increased in women 60 years of age in Gwangju and Jeonnam, Korea. One of the most interestingresults of the histological diagnosis showed that genotype distribution in the high-risk group increasedwith high-risk lesions. These results do not mean that multiple infections are more dangerous but may bean important factor in specific high-risk HPV genotypes. Conclusions: The prevalent HPV genotypes were HPV 16, 58, 18, 33, and 52 in the histological analysis.
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