Recent Epidemiological Changes in Group B Streptococcus Among Pregnant Korean Women
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Background: Although group B Streptococcus (GBS) colonization rate among pregnant Korean women is lower than that among women from many Western countries, recent data show an upward trend. We investigated recent epidemiological changes in GBS among pregnant Korean women in terms of colonization rate, antimicrobial susceptibility, serotype, and resistance genotype. Methods: Vaginal and anorectal swab specimens from 379 pregnant Korean women were cultured on Strep B Carrot Broth with GBS Detect (Hardy Diagnostics, USA), selective Todd-Hewitt broth (Becton Dickinson, USA), and Granada agar plate medium (Becton Dickinson). The antimicrobial susceptibility, serotypes, and macrolide-lincosamide-streptogramin B (MLSB) resistance genes of the GBS isolates were tested. Results: The GBS colonization rate among pregnant Korean women was 19.8% (75/379). Colonization rates using Strep B Carrot Broth with GBS Detect, selective Todd-Hewitt broth, and Granada agar plate medium cultures were 19.5%, 19.3%, and 15.0%, respectively. Six pregnant women were colonized by non-beta-hemolytic GBS and were detected only in Strep B Carrot Broth with GBS Detect. Resistance rates of GBS to clindamycin, erythromycin, and tetracycline were 16.0%, 28.0%, and 42.7%, respectively. The most common GBS serotypes were V (22.7%), VIII (20.0%), and III (20.0%). The frequency of MLSB resistance genes erm(B) and erm(TR) were 63.6% and 36.4%, respectively. Conclusions: The GBS colonization rate among pregnant Korean women has risen to levels observed in Western countries. To accurately evaluate GBS epidemiology among pregnant Korean women, periodic studies in multiple centers, including primary clinics, are necessary.
Abstract
Background: Although group B Streptococcus (GBS) colonization rate among pregnant Korean women is lower than that among women from many Western countries, recent data show an upward trend. We investigated recent epidemiological changes in GBS among pregnant Korean women in terms of colonization rate, antimicrobial susceptibility, serotype, and resistance genotype. Methods: Vaginal and anorectal swab specimens from 379 pregnant Korean women were cultured on Strep B Carrot Broth with GBS Detect (Hardy Diagnostics, USA), selective Todd-Hewitt broth (Becton Dickinson, USA), and Granada agar plate medium (Becton Dickinson). The antimicrobial susceptibility, serotypes, and macrolide-lincosamide-streptogramin B (MLSB) resistance genes of the GBS isolates were tested. Results: The GBS colonization rate among pregnant Korean women was 19.8% (75/379). Colonization rates using Strep B Carrot Broth with GBS Detect, selective Todd-Hewitt broth, and Granada agar plate medium cultures were 19.5%, 19.3%, and 15.0%, respectively. Six pregnant women were colonized by non-beta-hemolytic GBS and were detected only in Strep B Carrot Broth with GBS Detect. Resistance rates of GBS to clindamycin, erythromycin, and tetracycline were 16.0%, 28.0%, and 42.7%, respectively. The most common GBS serotypes were V (22.7%), VIII (20.0%), and III (20.0%). The frequency of MLSB resistance genes erm(B) and erm(TR) were 63.6% and 36.4%, respectively. Conclusions: The GBS colonization rate among pregnant Korean women has risen to levels observed in Western countries. To accurately evaluate GBS epidemiology among pregnant Korean women, periodic studies in multiple centers, including primary clinics, are necessary.
참고문헌 (30)
- Edwards MS, "Remington and Klein’s infectious diseases of the fetus and newborn infant", pp.41~56 (2016), Elsevier
- Libster R, "Long-term outcomes of group B streptococcal meningitis", Pediatrics, 130, pp.e8~e15 (2012)
- Berardi A, "Group B streptococcus late-onset disease: 2003-2010", Pediatrics, 131, pp.e361~e368 (2010)
- Nanduri SA, "Epidemiology of invasive early-onset and late-onset group B streptococcal disease in the United States, 2006 to 2015: multistate laboratory and population-based surveillance", JAMA Pediatr, 173, pp.224~233 (2019)
- Campbell JR, "Influence of serotype of group B streptococci on C3 degradation", Infect Immun, 60, pp.4558~4562 (1992)
- Uh Y, "Antimicrobial resistance and serotypes in the clinical isolates of group B streptococci", Korean J Clin Microbiol, 2, pp.64~70 (1999)
- Uh Y, "Serotypes and genotypes of erythromycin-resistant group B streptococci in Korea", J Clin Microbiol, 42, pp.3306~3308 (2004)
- 어영, "임신부의 Group B Streptococci 보균율, 혈청형 및 Macrolide-Lincosamide-StreptograminB 내성형의 분포", Annals of Clinical Microbiology, 12(4), pp.174~179 (2009), 대한임상미생물학회
- Edwards MS, "Principles and practice of pediatric infectious diseases", pp.723~729 (2018), Elsevier
- 김다현, "Prevalence of group B streptococcus colonization in pregnant women in a tertiary care center in Korea", Obstetrics & Gynecology Science, 61(5), pp.575~583 (2018), 대한산부인과학회[DOI]
- Uh Y, "Colonization rate of group B Streptococcus in pregnant women and neonates", Korean J Clin Pathol, 14, pp.447~453 (1994)
- Uh Y, "Colonization rates and serotypes of group B streptococci isolated from pregnant women in a Korean tertiary hospital", Eur J Clin Microbiol Infect Dis, 16, pp.753~756 (1997)
- Park KH, "Current status and clinical presentations of invasive neonatal Group B streptococcal infections in Korea", Pediatr Int, 53, pp.236~239 (2011)
- CLSI, "Performance standards for antimicrobial susceptibility testing" (2019), Clinical and Laboratory Standards Institute
- Kataja J, "Erythromycin resistance genes in group A streptococci in Finland", Antimicrob Agents Chemother, 43, pp.48~52 (1999)
- Sutcliffe J, "Detection of erythromycin-resistant determinants by PCR", Antimicrob Agents Chemother, 40, pp.2562~2566 (1996)
- "Prevention of perinatal group B streptococcal disease: a public health perspective", MMWR Recomm Rep, 45, pp.1~24 (1996), Centers for Disease Control and Prevention
- Le Doare K, "Intrapartum antibiotic chemoprophylaxis policies for the prevention of group B streptococcal disease worldwide: systematic review", Clin Infect Dis, 65(S2), pp.S143~S151 (2017)
- Dillon HC Jr, "Anorectal and vaginal carriage of group B streptococci during pregnancy", J Infect Dis, 145, pp.794~799 (1982)
- El Aila NA, "Comparison of different sampling techniques and of different culture methods for detection of group B streptococcus carriage in pregnant women", BMC Infect Dis, 10, pp.285~ (2010)
- Uh Y, "Serotypes and biochemical reaction patterns of group B streptococci", Korean J Clin Pathol, 18, pp.386~390 (1998)
- Furfaro LL, "Detection of group B Streptococcus during antenatal screening in Western Australia: a comparison of culture and molecular methods", J Appl Microbiol, 127, pp.598~604 (2019)
- Verani JR, "Prevention of perinatal group B streptococcal disease–revised guidelines from CDC, 2010", MMWR Recomm Rep, 59, pp.1~36 (2010)
- 이아람, "First Case in Korea of Group B Streptococcus With Reduced Penicillin Susceptibility Harboring Amino Acid Substitutions in Penicillin-Binding Protein 2X", Annals of Laboratory Medicine, 39(4), pp.414~416 (2019), 대한진단검사의학회[DOI]
- "Prevention of group B streptococcal early-onset disease in newborns: ACOG committee opinion summary, number 797", Obstet Gynecol, 135, pp.489~492 (2020)
- Takashi Takahashi, "Clonal Distribution of Clindamycin-Resistant Erythromycin-Susceptible (CRES) <italic>Streptococcus agalactiae<", italic> in Korea Based on Whole Genome Sequences, 2020, pp.40(5), 370~381[DOI]
- Lachenauer CS, "Serotypes VI and VIII predominate among group B streptococci isolated from pregnant Japanese women", J Infect Dis, 179, pp.1030~1033 (1999)
- Kimura K, "Active screening of group B streptococci with reduced penicillin susceptibility and altered serotype distribution isolated from pregnant women in Kobe, Japan", Jpn J Infect Dis, 66, pp.158~160 (2013)
- Omura Y, "Mediastinal, subcutaneous and multiple muscular abscesses caused by group B Streptococcus serotype VIII in a type 2 diabetes mellitus patient", J Infect Chemother, 24, pp.401~403 (2018)
- Mikamo H, "Adherence to, invasion by, and cytokine production in response to serotype VIII group B streptococci", Infect Immun, 72, pp.4716~4722 (2004)