A Retrospective National Study on Colonization Rate and Antimicrobial Susceptibility of Streptococcus agalactiae in Pregnant Korean Women, 2018–2020
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Purpose: The prevalence of Group B Streptococcus (GBS) colonization in pregnant Korean women is increasing; however, nation wide studies are lacking. Therefore, we aimed to analyze regional colonization rates and antimicrobial susceptibility for GBS inpregnant Korean women through a nationwide survey. Materials and Methods: From January 2018 to December 2020, data from the Seoul Clinical Laboratories on vaginal swab cultureswere retrospectively analyzed to detect maternal GBS carriers. Each swab specimen was inoculated onto a 5% blood agar plateand incubated at 35°C–37°C in a 5% CO2 incubator for 24 h. GBS isolates were identified using a Microflex MALDI Biotyper. Anti microbial susceptibility tests were performed using the Vitek 2 automated system. Results: The overall nationwide GBS colonization rate in pregnant Korean women was found to be 10.6% (3578/33721). The ma ternal GBS colonization rates ranged from 10.5%–10.8% over the 3-year study period. The GBS colonization rates by province, indescending order, were as follows: Jeolla-do, 13.2%; Gangwon-do, 12.0%; Chungcheong-do, 11.8%; Gyeonggi-do, 11.3%; Seoul,10.2%; and Gyeongsang-do, 9.6%. During the study period, the resistance rates against chloramphenicol, levofloxacin, clindamy cin, erythromycin, and tetracycline were 2.6%–2.7%, 18.2%–19.6%, 33.4%–35.7%, 35.6%–36.8%, and 50.5%–53.3%, respectively. Conclusion: In pregnant Korean women, GBS colonization rates were in the range of 9.6%–13.2%, with Gyeongsang-do being thelowest and Jeolla-do the highest. The resistance rate against clindamycin was high (33.4%–35.7%). GBS colonization rates duringpregnancy should be studied nationwide according to the Centers for Disease Control and Prevention-recommended guidelineswith periodic antimicrobial resistance monitoring.
Abstract
Purpose: The prevalence of Group B Streptococcus (GBS) colonization in pregnant Korean women is increasing; however, nation wide studies are lacking. Therefore, we aimed to analyze regional colonization rates and antimicrobial susceptibility for GBS inpregnant Korean women through a nationwide survey. Materials and Methods: From January 2018 to December 2020, data from the Seoul Clinical Laboratories on vaginal swab cultureswere retrospectively analyzed to detect maternal GBS carriers. Each swab specimen was inoculated onto a 5% blood agar plateand incubated at 35°C–37°C in a 5% CO2 incubator for 24 h. GBS isolates were identified using a Microflex MALDI Biotyper. Anti microbial susceptibility tests were performed using the Vitek 2 automated system. Results: The overall nationwide GBS colonization rate in pregnant Korean women was found to be 10.6% (3578/33721). The ma ternal GBS colonization rates ranged from 10.5%–10.8% over the 3-year study period. The GBS colonization rates by province, indescending order, were as follows: Jeolla-do, 13.2%; Gangwon-do, 12.0%; Chungcheong-do, 11.8%; Gyeonggi-do, 11.3%; Seoul,10.2%; and Gyeongsang-do, 9.6%. During the study period, the resistance rates against chloramphenicol, levofloxacin, clindamy cin, erythromycin, and tetracycline were 2.6%–2.7%, 18.2%–19.6%, 33.4%–35.7%, 35.6%–36.8%, and 50.5%–53.3%, respectively. Conclusion: In pregnant Korean women, GBS colonization rates were in the range of 9.6%–13.2%, with Gyeongsang-do being thelowest and Jeolla-do the highest. The resistance rate against clindamycin was high (33.4%–35.7%). GBS colonization rates duringpregnancy should be studied nationwide according to the Centers for Disease Control and Prevention-recommended guidelineswith periodic antimicrobial resistance monitoring.
참고문헌 (26)
- Edwards MS, "Remington and Klein’s infectious diseases of the fetus and newborn infant", pp.411~456 (2016), Elsevier
- Libster R, "Long-term outcomes of group B streptococcal meningitis", Pediatrics, 130, pp.e8~e15 (2012)
- American College of Obstetricians and Gynecologists, "Prevention of group B streptococcal early-onset disease in newborns: ACOG committee opinion summary, number 797", Obstet Gynecol, 135, pp.489~492 (2020)
- Nanduri SA, "Epidemiology of invasive early-onset and late-onset group B streptococcal disease in the United States, 2006 to 2015 : multistate laboratory and population-based surveillance", JAMA Pediatr, 173, pp.224~233 (2019)
- Edwards MS, "Principles and practice of pediatric infectious diseases", pp.723~735 (2018), Elsevier
- 김다현, "Prevalence of group B streptococcus colonization in pregnant women in a tertiary care center in Korea", Obstetrics & Gynecology Science, 61(5), pp.575~583 (2018), 대한산부인과학회[DOI]
- 최성진, "Recent Epidemiological Changes in Group B Streptococcus Among Pregnant Korean Women", Annals of Laboratory Medicine, 41(4), pp.380~385 (2021), 대한진단검사의학회[DOI]
- Uh Y, "Colonization rate of group B Streptococcus in pregnant women and neonates", Korean J Clin Pathol, 14, pp.447~453 (1994)
- Uh Y, "Colonization rates and serotypes of group B streptococci isolated from pregnant women in a Korean tertiary hospital", Eur J Clin Microbiol Infect Dis, 16, pp.753~756 (1997)
- 어영, "임신부의 Group B Streptococci 보균율, 혈청형 및 Macrolide-Lincosamide-StreptograminB 내성형의 분포", Annals of Clinical Microbiology, 12(4), pp.174~179 (2009), 대한임상미생물학회
- Uh Y, "Emerging erythromycin resistance among group B streptococci in Korea", Eur J Clin Microbiol Infect Dis, 20, pp.52~54 (2001)
- Yoon IA, "Clinical significance of serotype V among infants with invasive group B streptococcal infections in South Korea", Int J Infect Dis, 38, pp.136~140 (2015)
- Tejada JJ, "On the misuse of Slovin’s formula", Philipp Stat, 61, pp.129~136 (2012)
- Pourhoseingholi MA, "Sample size calculation in medical studies", Gastroenterol Hepatol Bed Bench, 6, pp.14~17 (2013)
- Clinical and Laboratory Standards Institute, "Performance standards for antimicrobial susceptibility testing" (2019), Clinical and Laboratory Standards Institute
- Hong JS, "Genital group B streptococcus carrier rate and serotype distribution in Korean pregnant women : implications for group B streptococcal disease in Korean neonates", J Perinat Med, 38, pp.373~377 (2010)
- Verani JR, "Prevention of perinatal group B streptococcal disease : revised guidelines from CDC, 2010", MMWR Recomm Rep, 59, pp.1~36 (2010)
- Six A, "Molecular characterization of nonhemolytic and nonpigmented group B streptococci responsible for human invasive infections", J Clin Microbiol, 54, pp.75~82 (2016)
- Uh Y, "Serotypes and biochemical reaction patterns of group B streptococci", Korean J Clin Pathol, 18, pp.386~390 (1998)
- Sørensen UBS, "The distribution of clones of Streptococcus agalactiae(group B streptococci)among herdspersons and dairy cows demonstrates lack of host specificity for some lineages", Vet Microbiol, 235, pp.71~79 (2019)
- Sørensen UB, "Emergence and global dissemination of host-specific Streptococcus agalactiae clones", mBio, 1, pp.e00178-10~ (2010)
- Duarte RS, "Phenotypic and molecular characteristics of Streptococcus agalactiae isolates recovered from milk of dairy cows in Brazil", J Clin Microbiol, 42, pp.4214~4222 (2004)
- Verani JR, "Prevention of perinatal group B streptococcal disease--revised guidelines from CDC, 2010", MMWR Recomm Rep, 59, pp.1~36 (2010)
- 이아람, "First Case in Korea of Group B Streptococcus With Reduced Penicillin Susceptibility Harboring Amino Acid Substitutions in Penicillin-Binding Protein 2X", Annals of Laboratory Medicine, 39(4), pp.414~416 (2019), 대한진단검사의학회[DOI]
- Leykun Y, "Group B streptococci vaginal-recto colonization, vertical transmission to newborns, antimicrobial susceptibility profile and associated factors in selected health facilities of Bahir Dar city : a cross-sectional study", Infect Drug Resist, 14, pp.5457~5472 (2021)
- Safari D, "Prevalence, serotype and antibiotic susceptibility of group B Streptococcus isolated from pregnant women in Jakarta, Indonesia", PLoS One, 16, pp.e0252328~ (2021)