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Citrulline 섭취가 20대 남성의 일회성 유산소운동후 혈압, 심혈관기능 및 혈중 젖산농도에 미치는 영향

Effects of citrulline supplementation on blood pressure, cardiovascular function, and blood lactate after a bout of aerobic exercise in 20s males

조현석|이만균|정인찬
국민체육진흥공단 한국스포츠과학원 (Korea Institute of Sport Science)|2016.09|체육과학연구 (Korean Journal of Sport Science)|제27권 제3호|pp. 480-495|DOI 10.24985/kjss.2016.27.3.480

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참고문헌

키워드

혈압blood pressurenitric oxide운동후 저혈압시트룰린알기닌일산화 질소citrullineargininepost-exercise hypotension.
주제분류체육

초록

일회성 운동 후에 나타나는 운동후 저혈압(post-exercise hypotension: PEH) 반응은 운동 트레이닝을 통한 혈압 감소의 주요 기전으로 알려져 있으며, citrulline의 섭취는 체내 일산화 질소(nitric oxide: NO)를 증가시켜 혈압을 감소시키는 것으로 알려져 있으나, citrulline 섭취가 PEH에 미치는 영향을 규명한 연구가 매우 부족한 실정이다. 따라서 이 연구에서는 고혈압 전단계와 정상혈압 범주의 20대 남성을 대상으로 citrulline 섭취가 PEH에 미치는 영향을 규명하고자 하였다. 각각 4일간의 citrulline 처치와 placebo 처치(비처치)가 안정시와 VO2max 70% 강도로 30분간 실시한 유산소운동 후 회복기 중 혈압, 심혈관기능, 그리고 혈중 젖산농도에 미치는 영향을 비교ㆍ분석하였다. 모든 대상자는 citrulline 처치 실험과 placebo 처치 실험에 counter- balanced order에 따라 반복 참여하였다. 이 연구의 주요 결과를 요약하여 기술하면 다음과 같다. 1) Citrulline 처치를 한 경우 회복기 10~60분 시점에서 SBP와 DBP, 그리고 MAP가 비처치에 비하여 유의하게 낮게 나타났다. RPP는 citrulline 처치가 비처치에 비하여 회복기 30분과 45분 시점에서 유의하게 낮은 것으로 나타났다. 2) Citrulline 처치와 비처치 간에 안정시와 회복기 중 SV를 제외한 HR, CO, 그리고 TPR은 유의한 차이가 나타나지 않았다. 각 처치 내에서 HR, SV, CO, 그리고 TPR 모두 시기 간에는 유의한 차이가 나타났다. 3) Citrulline 처치와 비처치 간에 안정시와 회복기 중 혈중 젖산농도는 유의한 차이가 나타나지 않았다. 이상의 결과를 종합해 보면, citrulline 처치가 비처치에 비하여 PEH 반응을 더욱 크게 나타나도록 하였으며, citrulline 처치가 혈압만 낮출 뿐 심장에 대한 부담 또는 기타 심혈관계 반응에는 큰 영향을 미치지 않는 것으로 나타났다. 즉, 단기간의 citrulline 섭취가 심장에 부담을 주지 않으면서 PEH 반응을 더 크게 하는 효과적인 처치라고 결론지을 수 있다. 향후 고혈압환자를 대상으로 하는 후속 연구가 요청되며, 이들을 대상으로도 이 연구과 유사한 결과가 나타난다면 장기간에 걸쳐 citrulline을 섭취하면서 운동 트레이닝을 하면 더 큰 PEH 반응이 누적되어 고혈압환자의 혈압 감소에 더욱 효과적일 것으로 기대된다. 향후 고혈압환자를 대상으로 운동 트레이닝의 혈압감소 효과를 검증하는 과정에서 citrulline 섭취 여부에 따른 효과를 규명하는 연구가 요청된다.

Abstract

It has well known that post-exercise hypotension (PEH) after a bout of aerobic exercise was a major mechanism to reduce blood pressure though exercise training, and that citrulline supplementation reduced blood pressure by increasing nitric oxide in vivo. However, the effects of citrulline supplementation on PEH have not been fully elucidated yet. This study was designed to examine the effects of citrulline supplementation on PEH after a bout of aerobic exercise in prehypertensive and normotensive 20s males. The effects of a four-day citrulline or placebo treatment on blood pressure, cardiovascular function, and blood lactate concentration measured at rest and during recovery phase after a bout of exercise performed for 30 min at 70% VO2max were compared and analyzed. All subjects participated in a citrulline trial and a placebo trial repeatedly according to a counter-balanced order. Main results of the present study were as follows: 1) Systolic blood pressure, diastolic blood pressure, and mean arterial pressure measured at 10-60 min of recovery phase in citrulline trial were significantly lower than placebo trial. Rate-pressure product measured at 30 min and 45 min of the recovery phase in citrulline trial was significantly lower than placebo trial. 2) No significant differences were found in heart rate (HR), cardiac output (CO), and total peripheral resistance (TPR) measured during the recovery phase between two trials. There were significant differences in HR, stroke volume, CO, and TPR among times within a trial. 3) No significant difference was found in blood lactate concentration measured at rest and during the recovery phase between two trials. The results would be summarized that the PEH was augmented by the citrulline supplementation, and that burden to cardiac muscle as well as cardiovascular function were not affected by the citrulline supplementation. It was concluded that the short-term citrulline supplementation would be very effective to augment the PEH. A research investigating the effects of citrulline supplementation on the PEH in pre-hypertensive and/or hypertensive individuals would be warranted. In addition, a study examining the effects of citrulline supplementation during long-term exercise training on the blood pressure in hypertensive patients also would be warranted in near future.

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