Febantel 경구 투여에 따른 뱀장어(Anguilla japonica)의 독성 평가
Evaluation of the toxicity of orally administered Febantel in Japanese eel Anguilla japonica
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In this study, the toxicity of febantel was assessed in Japanese eel (Anguilla japonica) using survival analysis, serum biochemical assays, and histopathological examination. For the survival analysis, the eels were assigned to four groups: a control group and three febantel-treated groups receiving 50, 100, or 200 mg/kg of the drug, administered once daily for five consecutive days. The control group exhibited a cumulative mortality rate of approximately 7% by day 14, whereas all febantel-treated groups showed 100% cumulative mortality, although the onset of mortality varied among groups. Histopathological analysis was performed on the group administered 100 mg/kg of febantel. Compared to the control group, notable pathological changes included hyperplasia of the secondary lamellae and an increased number of mucous cells in the gills, tubular atrophy and necrosis in the kidneys, phagocytosis of hematopoietic tissue by macrophages, and inflammation with epithelial damage in the gastrointestinal tract. These lesions were primarily classified as regressive changes associated with functional deterioration. Collectively, the findings indicate that febantel exerts severe toxic effects in Japanese eel.
Abstract
In this study, the toxicity of febantel was assessed in Japanese eel (Anguilla japonica) using survival analysis, serum biochemical assays, and histopathological examination. For the survival analysis, the eels were assigned to four groups: a control group and three febantel-treated groups receiving 50, 100, or 200 mg/kg of the drug, administered once daily for five consecutive days. The control group exhibited a cumulative mortality rate of approximately 7% by day 14, whereas all febantel-treated groups showed 100% cumulative mortality, although the onset of mortality varied among groups. Histopathological analysis was performed on the group administered 100 mg/kg of febantel. Compared to the control group, notable pathological changes included hyperplasia of the secondary lamellae and an increased number of mucous cells in the gills, tubular atrophy and necrosis in the kidneys, phagocytosis of hematopoietic tissue by macrophages, and inflammation with epithelial damage in the gastrointestinal tract. These lesions were primarily classified as regressive changes associated with functional deterioration. Collectively, the findings indicate that febantel exerts severe toxic effects in Japanese eel.