양식 뱀장어(Anguilla japonica)에서 florfenicol의 경구투여에 따른 잔류 연구
Residue analysis of florfenicol in cultured eel Anguilla japonica following oral administration
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초록
Florfenicol (FF) is a member of chloramphenicol (CM) family member of antibiotics developed to take advantage of not causing aplastic anemia, the typical side effect of CM. Because FF is a safe veterinary drug it is also approved for clinical use for fish in Korea. The usage, dose and withdrawal period of FF in Korea are the same as in Japan, but the maximum residue limit (MRL) is set differently for eel, 0.2 mg/kg in Korea and 8.0 mg/kg in Japan. However, there is a lack of research on residue characteristics that meets domestic standards to support this claim. In this study, we conducted tests in order to set a drug withdrawal period in cultured eel Anguilla japonica. Following administrate of FF up to 20 mg/kg, twice the approved clinical dose of 10 mg/kg for 5-days, it is residual was evaluated. Trend. It was found that the previously set 7-day withdrawal period needs to be extended to approximatiy to 60 days. The results of this study were used as evidence for the recent year 2022 extension of the withdrawal period from 7 to 60 days.
Abstract
Florfenicol (FF) is a member of chloramphenicol (CM) family member of antibiotics developed to take advantage of not causing aplastic anemia, the typical side effect of CM. Because FF is a safe veterinary drug it is also approved for clinical use for fish in Korea. The usage, dose and withdrawal period of FF in Korea are the same as in Japan, but the maximum residue limit (MRL) is set differently for eel, 0.2 mg/kg in Korea and 8.0 mg/kg in Japan. However, there is a lack of research on residue characteristics that meets domestic standards to support this claim. In this study, we conducted tests in order to set a drug withdrawal period in cultured eel Anguilla japonica. Following administrate of FF up to 20 mg/kg, twice the approved clinical dose of 10 mg/kg for 5-days, it is residual was evaluated. Trend. It was found that the previously set 7-day withdrawal period needs to be extended to approximatiy to 60 days. The results of this study were used as evidence for the recent year 2022 extension of the withdrawal period from 7 to 60 days.
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