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Amprolium hydrochloride 투여에 따른 넙치(Paralichthys olivaceus)의 독성 영향

Toxic effect in olive flounder Paralichthys olivaceus after intramuscular administration of amprolium hydrochloride

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초록

The aim of this study was to examine the effect of amprolium hydrochloride on olive flounder Paralichthys olivaceus. Thirty flounder (average weight 230.27 g; average length 27.99 cm) was randomly allocated into six groups, namely, 50, 100, 150, 200, 400 and 600 mg/kg. As measure of acute toxicity the LD50 value of 148.18 mg/kg was obtained. Hematologic analysis was performed on days 1, 3, 7, 14, and 28 after the intramuscular injection of the drug. Among the plasma biochemistry profiles, glutamic oxalate transaminase (GOT) activity and blood urea nitrogen (BUN) were found significantly increased. In addition, histopathology analysis revealed frequent appearance of melanomacrophage center (MMC) and edema in the renal tissues after 20, 40 and 80 mg/kg on day 7, 14, 28. In summary, amprolium exposure seem to cause adverse effects of flounders.

Abstract

The aim of this study was to examine the effect of amprolium hydrochloride on olive flounder Paralichthys olivaceus. Thirty flounder (average weight 230.27 g; average length 27.99 cm) was randomly allocated into six groups, namely, 50, 100, 150, 200, 400 and 600 mg/kg. As measure of acute toxicity the LD50 value of 148.18 mg/kg was obtained. Hematologic analysis was performed on days 1, 3, 7, 14, and 28 after the intramuscular injection of the drug. Among the plasma biochemistry profiles, glutamic oxalate transaminase (GOT) activity and blood urea nitrogen (BUN) were found significantly increased. In addition, histopathology analysis revealed frequent appearance of melanomacrophage center (MMC) and edema in the renal tissues after 20, 40 and 80 mg/kg on day 7, 14, 28. In summary, amprolium exposure seem to cause adverse effects of flounders.

참고문헌 (49)

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