Alteration of Semantic Networks during Swear Words Processing in Schizophrenia
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Objective: Positive symptoms, such as delusion and hallucination, commonly include negative emotional content in schizophrenia. We investigated the neural basis implicated during the processing of strong negative emotional words in patients with schizophrenia. Methods: In our study, 35 patients with schizophrenia and 19 healthy controls were recruited, and the participants were asked to passively view the words that contained swearing and neutral content during functional magnetic resonance imaging. Results: Patients with schizophrenia, compared to healthy controls, showed hypoactivation to the swear and neutral words stimuli in the left inferior frontal gyrus, left middle frontal gyrus, and left angular/supramarginal gyrus. More specifically, patients with remitted schizophrenia were found to have greater activation to the stimuli in the left middle/inferior frontal gyrus than patients with active schizophrenia. Furthermore, in the analysis of regions of interests, the left inferior and middle frontal gyrus activity was related to the severity of positive symptoms, including delusion and suspiciousness. Conclusion: Our results suggest that patients with schizophrenia have difficulty in semantic processing and inhibitory control of swear words, and these abnormalities may be connected with the severity of positive symptoms.
Abstract
Objective: Positive symptoms, such as delusion and hallucination, commonly include negative emotional content in schizophrenia. We investigated the neural basis implicated during the processing of strong negative emotional words in patients with schizophrenia. Methods: In our study, 35 patients with schizophrenia and 19 healthy controls were recruited, and the participants were asked to passively view the words that contained swearing and neutral content during functional magnetic resonance imaging. Results: Patients with schizophrenia, compared to healthy controls, showed hypoactivation to the swear and neutral words stimuli in the left inferior frontal gyrus, left middle frontal gyrus, and left angular/supramarginal gyrus. More specifically, patients with remitted schizophrenia were found to have greater activation to the stimuli in the left middle/inferior frontal gyrus than patients with active schizophrenia. Furthermore, in the analysis of regions of interests, the left inferior and middle frontal gyrus activity was related to the severity of positive symptoms, including delusion and suspiciousness. Conclusion: Our results suggest that patients with schizophrenia have difficulty in semantic processing and inhibitory control of swear words, and these abnormalities may be connected with the severity of positive symptoms.
참고문헌 (49)
- Kohler CG, "Facial emotion perception in schizophrenia : a meta-analytic review", Schizophr Bull, 36, pp.1009~1019 (2010)
- Habel U, "Neural correlates of emotion recognition in schizophrenia", Schizophr Res, 122, pp.113~123 (2010)
- Herbener ES, "Emotional memory in schizophrenia", Schizophr Bull, 34, pp.875~887 (2008)
- Lee SK, "Abnormal neural processing during emotional salience attribution of affective asymmetry in patients with schizophrenia", PLoS One, 9, pp.e90792~ (2014)
- Strauss GP, "Emotion regulation abnormalities in schizophrenia : cognitive change strategies fail to decrease the neural response to unpleasant stimuli", Schizophr Bull, 39, pp.872~883 (2013)
- van der Meer L, "Neural correlates of emotion regulation in patients with schizophrenia and non-affected siblings", PLoS One, 9, pp.e99667~ (2014)
- Hooker C, "Emotion processing and its relationship to social functioning in schizophrenia patients", Psychiatry Res, 112, pp.41~50 (2002)
- Mueser KT, "Emotion recognition and social competence in chronic schizophrenia", J Abnorm Psychol, 105, pp.271~275 (1996)
- Kee KS, "Is emotion processing a predictor of functional outcome in schizophrenia", Schizophr Bull, 29, pp.487~497 (2003)
- Myin-Germeys I, "Schizophrenia patients are more emotionally active than is assumed based on their behavior", Schizophr Bull, 26, pp.847~854 (2000)
- Myin-Germeys I, "Sex differences in emotional reactivity to daily life stress in psychosis", J Clin Psychiatry, 65, pp.805~809 (2004)
- Li H, "Facial emotion processing in schizophrenia : a meta-analysis of functional neuroimaging data", Schizophr Bull, 36, pp.1029~1039 (2010)
- Satterthwaite TD, "Association of enhanced limbic response to threat with decreased cortical facial recognition memory response in schizophrenia", Am J Psychiatry, 167, pp.418~426 (2010)
- Sanjuan J, "Emotional words induce enhanced brain activity in schizophrenic patients with auditory hallucinations", Psychiatry Res, 154, pp.21~29 (2007)
- Vercammen A, "Reduced neural activity of the prefrontal cognitive control circuitry during response inhibition to negative words in people with schizophrenia", J Psychiatry Neurosci, 37, pp.379~388 (2012)
- Klumpp H, "Semantic processing of emotional words in depression and schizophrenia", Int J Psychophysiol, 75, pp.211~215 (2010)
- Jamadar SD, "Semantic association fMRI impairments represent a potential schizophrenia biomarker", Schizophr Res, 145, pp.20~26 (2013)
- Vingerhoets AJJM, "Swearing : A biopsychosocial perspective", Psychological Topics, 22, pp.287~304 (2013)
- Upthegrove R, "Auditory verbal hallucinations in first-episode psychosis : a phenomenological investigation", BJPsych Open, 2, pp.88~95 (2016)
- Daalman K, "The same or different? A phenomenological comparison of auditory verbal hallucinations in healthy and psychotic individuals", J Clin Psychiatry, 72, pp.320~325 (2011)
- Freeman D, "Suspicious minds : the psychology of persecutory delusions", Clin Psychol Rev, 27, pp.425~457 (2007)
- Larsen TK, "Premorbid functioning versus duration of untreated psychosis in 1 year outcome in first-episode psychosis", Schizophr Res, 45, pp.1~9 (2000)
- First MB, "Structured clinical interview for DSM-IV-TR Axis I disorders: Patient edition", Biometrics Research Department, Columbia University, ~ (2005)
- Kay SR, "The positive and negative syndrome scale(PANSS)for schizophrenia", Schizophr Bull, 13, pp.261~276 (1987)
- Haro JM, "The Clinical Global Impression-Schizophrenia scale: a simple instrument to measure the diversity of symptoms present in schizophrenia", Acta Psychiatr Scand Suppl, (416), pp.16~23 (2003)
- A national survey on language use and language attitude in adolescents, "Chang K", The National Institute of The Korean Language, ~ (2011)
- Toglia MP, "Handbook of semantic word norms" (1978), Erlbaum
- Bradley MM, "Affective Norms for English Words (ANEW): Instruction manual and affective ratings" (1999), University of Florida, Center for Research in Psychophysiology
- Jenkinson M, "FSL", Neuroimage, 62, pp.782~790 (2012)
- Greve DN, "Accurate and robust brain image alignment using boundary-based registration", Neuroimage, 48, pp.63~72 (2009)
- Rapp AM, "Functional MRI of sentence-level language comprehension in schizophrenia : a coordinatebased analysis", Schizophr Res, 150, pp.107~113 (2013)
- Hales RE, "The American psychiatric publishing textbook of psychiatry" (2008), American Psychiatric Pub
- Lau EF, "A cortical network for semantics : (de)constructing the N400", Nat Rev Neurosci, 9, pp.920~933 (2008)
- Seghier ML, "The angular gyrus : multiple functions and multiple subdivisions", Neuroscientist, 19, pp.43~61 (2013)
- Houdé O, "Mapping numerical processing, reading, and executive functions in the developing brain : an fMRI meta-analysis of 52 studies including 842 children", Dev Sci, 13, pp.876~885 (2010)
- Price CJ, "Reading and reading disturbance", Curr Opin Neurobiol, 15, pp.231~238 (2005)
- Nierenberg J, "Reduced left angular gyrus volume in first-episode schizophrenia", Am J Psychiatry, 162, pp.1539~1541 (2005)
- Niznikiewicz M, "Abnormal angular gyrus asymmetry in schizophrenia", Am J Psychiatry, 157, pp.428~437 (2000)
- Jeong B, "Reduced task-related suppression during semantic repetition priming in schizophrenia", Psychiatry Res, 181, pp.114~120 (2010)
- Jeong B, "Functional and anatomical connectivity abnormalities in left inferior frontal gyrus in schizophrenia", Hum Brain Mapp, 30, pp.4138~4151 (2009)
- Hagoort P, "Integration of word meaning and world knowledge in language comprehension", Science, 304, pp.438~441 (2004)
- Swick D, "Left inferior frontal gyrus is critical for response inhibition", BMC Neurosci, 9, pp.102~ (2008)
- Kubicki M, "An fMRI study of semantic processing in men with schizophrenia", Neuroimage, 20, pp.1923~1933 (2003)
- Arbib MA, "Schizophrenia and the mirror system : an essay", Neuropsychologia, 43, pp.268~280 (2005)
- Tseng CE, "Altered cortical structures and tract integrity of the mirror neuron system in association with symptoms of schizophrenia", Psychiatry Res, 231, pp.286~291 (2015)
- Sprong M, "Theory of mind in schizophrenia : meta-analysis", Br J Psychiatry, 191, pp.5~13 (2007)
- Aleman A, "Strange feelings : do amygdala abnormalities dysregulate the emotional brain in schizophrenia", Prog Neurobiol, 77, pp.283~298 (2005)
- Moritz-Gasser S, "Integrating emotional valence and semantics in the human ventral stream : a hodological account", Front Psychol, 6, pp.32~ (2015)
- Borofsky LA, "Semantic processing and thought disorder in childhood-onset schizophrenia : Insights from fMRI", J Neurolinguistics, 23, pp.204~222 (2010)