Neural Signature for Auditory Hallucinations in Schizophrenia: A High-Resolution Positron Emission Tomography Study with Fludeoxyglucose (18F)
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Objective: Auditory hallucinations (AHs) are a core symptom of schizophrenia. We investigated the neural signature of AHs by comparing hallucinating patients with schizophrenia with non-hallucinating patients with schizophrenia. Methods: We recruited hallucinating patients with schizophrenia meeting the criteria for persistent, prominent, and predominant AHs (n=10) and non-hallucinating patients with schizophrenia (n=12). Various clinical assessments were performed incluing Psychotic Symptom Rating Scale for Auditory Hallucinations. Using fludeoxyglucose (18F) positron emission tomography, regional differences in neural activity between the groups were analyzed. Results: The regions of interest analysis showed significantly lower standardized uptake value ratio (SUVR) in the superior, middle, and inferior frontal gyri, and higher SUVR in the putamen in patients with AHs versus patients without AHs. These findings were confirmed in the voxel-wise analysis. Conclusion: Our findings indicate that hypoactivity in the frontal and cingulate gyri, coupled with hyperactivity in the temporal gyrus and putamen, may contribute to the pathophysiology of AHs.
Abstract
Objective: Auditory hallucinations (AHs) are a core symptom of schizophrenia. We investigated the neural signature of AHs by comparing hallucinating patients with schizophrenia with non-hallucinating patients with schizophrenia. Methods: We recruited hallucinating patients with schizophrenia meeting the criteria for persistent, prominent, and predominant AHs (n=10) and non-hallucinating patients with schizophrenia (n=12). Various clinical assessments were performed incluing Psychotic Symptom Rating Scale for Auditory Hallucinations. Using fludeoxyglucose (18F) positron emission tomography, regional differences in neural activity between the groups were analyzed. Results: The regions of interest analysis showed significantly lower standardized uptake value ratio (SUVR) in the superior, middle, and inferior frontal gyri, and higher SUVR in the putamen in patients with AHs versus patients without AHs. These findings were confirmed in the voxel-wise analysis. Conclusion: Our findings indicate that hypoactivity in the frontal and cingulate gyri, coupled with hyperactivity in the temporal gyrus and putamen, may contribute to the pathophysiology of AHs.
참고문헌 (60)
- van Os J, "A systematic review and meta-analysis of the psychosis continuum: evidence for a psychosis proneness- persistence-impairment model of psychotic disorder", Psychol Med, 39, pp.179~195 (2009)[DOI]
- Laroi F, "The characteristic features of auditory verbal hallucinations in clinical and nonclinical groups: state-of-theart overview and future directions", Schizophr Bull, 38, pp.724~733 (2012)[DOI]
- Carter DM, "Patients' strategies for coping with auditory hallucinations", J Nerv Ment Dis, 184, pp.159~164 (1996)[DOI]
- Pantelis C, "Drug strategies and treatment-resistant schizophrenia", Aust N Z J Psychiatry, 30, pp.20~37 (1996)[DOI]
- Breier A, "National Institute of Mental Health longitudinal study of chronic schizophrenia. Prognosis and predictors of outcome", Arch Gen Psychiatry, 48, pp.239~246 (1991)[DOI]
- Harkavy-Friedman JM, "Suicide attempts in schizophrenia: the role of command auditory hallucinations for suicide", J Clin Psychiatry, 64, pp.871~874 (2003)[DOI]
- 이승환, "치료저항성 환청을 지닌 정신분열병 환자의 임상특성 및 신경인지기능", 신경정신의학, 43(3), pp.288~295 (2004), 대한신경정신의학회
- Barta PE, "Auditory hallucinations and smaller superior temporal gyral volume in schizophrenia", Am J Psychiatry, 147, pp.1457~1462 (1990)[DOI]
- Gaser C, "Neuroanatomy of hearing voices: a frontotemporal brain structural abnormality associated with auditory hallucinations in schizophrenia", Cereb Cortex, 14, pp.91~96 (2004)[DOI]
- Nenadic I, "Auditory hallucinations and brain structure in schizophrenia: voxel-based morphometric study", Br J Psychiatry, 196, pp.412~413 (2010)[DOI]
- Jardri R, "Cortical activations during auditory verbal hallucinations in schizophrenia: a coordinate-based meta-analysis", Am J Psychiatry, 168, pp.73~81 (2011)[DOI]
- Dierks T, "Activation of Heschl's gyrus during auditory hallucinations", Neuron, 22, pp.615~621 (1999)[DOI]
- Silbersweig DA, "A functional neuroanatomy of hallucinations in schizophrenia", Nature, 378, pp.176~179 (1995)[DOI]
- Sommer IE, "Auditory verbal hallucinations predominantly activate the right inferior frontal area", Brain, 131, pp.3169~3177 (2008)[DOI]
- Shergill SS, "Mapping auditory hallucinations in schizophrenia using functional magnetic resonance imaging", Arch Gen Psychiatry, 57, pp.1033~1038 (2000)[DOI]
- Horga G, "Differential brain glucose metabolic patterns in antipsychotic-naive first-episode schizophrenia with and without auditory verbal hallucinations", J Psychiatry Neurosci, 36, pp.312~321 (2011)[DOI]
- Kopecek M, "18FDG PET in hallucinating and non-hallucinating patients", Neuro Endocrinol Lett, 28, pp.53~59 (2007)
- Structured Clinical Interview for DSM-IV-TR Axis I disorders, Research Version, Patient Edition (SCID-I, "P)", First MB, 2002
- Kay SR, "The Positive and Negative Syndrome Scale (PANSS) for schizophrenia", Schizophr Bull, 13, pp.261~276 (1987)[DOI]
- Addington D, "Assessing depression in schizophrenia: the Calgary Depression Scale", Br J Psychiatry Suppl, (22), pp.39~44 (1993)
- Goldman HH, "Revising axis V for DSM-IV: a review of measures of social functioning", Am J Psychiatry, 149, pp.1148~1156 (1992)[DOI]
- Crawford JR, "The Prospective and Retrospective Memory Questionnaire (PRMQ): Normative data and latent structure in a large nonclinical sample", Memory, 11, pp.261~275 (2003)[DOI]
- Haddock G, "Scales to measure dimensions of hallucinations and delusions: the psychotic symptom rating scales (PSYRATS)", Psychol Med, 29, pp.879~889 (1999)[DOI]
- Cho ZH, "A fusion PET-MRI system with a high-resolution research tomograph-PET and ultra-high field 7.0 T-MRI for the molecular-genetic imaging of the brain", Proteomics, 8, pp.1302~1323 (2008)[DOI]
- Wienhard K, "The ECAT HRRT: performance and first clinical application of the new high resolution research tomography", IEEE Trans Nucl Sci, 49, pp.104~110 (2002)[DOI]
- Hong IK, "Ultra fast symmetry and SIMD-based projection-backprojection (SSP) algorithm for 3-D PET image reconstruction", IEEE Trans Med Imaging, 26, pp.789~803 (2007)[DOI]
- Molina V, "Cerebral metabolic changes induced by clozapine in schizophrenia and related to clinical improvement", Psychopharmacology (Berl), 178, pp.17~26 (2005)[DOI]
- Tzourio-Mazoyer N, "Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain", Neuroimage, 15, pp.273~289 (2002)[DOI]
- Allen P, "The hallucinating brain: a review of structural and functional neuroimaging studies of hallucinations", Neurosci Biobehav Rev, 32, pp.175~191 (2008)[DOI]
- Hugdahl K, ""Hearing voices": auditory hallucinations as failure of top-down control of bottom-up perceptual processes", Scand J Psychol, 50, pp.553~560 (2009)[DOI]
- Copolov DL, "Cortical activation associated with the experience of auditory hallucinations and perception of human speech in schizophrenia: a PET correlation study", Psychiatry Res, 122, pp.139~152 (2003)[DOI]
- Parellada E, "Fluordeoxyglucose-PET study in first-episode schizophrenic patients during the hallucinatory state, after remission and during linguistic-auditory activation", Nucl Med Commun, 29, pp.894~900 (2008)[DOI]
- Kuhn S, "Quantitative meta-analysis on state and trait aspects of auditory verbal hallucinations in schizophrenia", Schizophr Bull, 38, pp.779~786 (2012)[DOI]
- Kang JI, "Abnormal brain response during the auditory emotional processing in schizophrenic patients with chronic auditory hallucinations", Schizophr Res, 107, pp.83~91 (2009)[DOI]
- Palmer SM, "A meta-analysis of changes in brain activity in clinical depression", Front Hum Neurosci, 8, pp.1045~ (2015)
- du Boisgueheneuc F, "Functions of the left superior frontal gyrus in humans: a lesion study", Brain, 129, pp.3315~3328 (2006)[DOI]
- Cutini S, "Selective activation of the superior frontal gyrus in task-switching: an event-related fNIRS study", Neuroimage, 42, pp.945~955 (2008)[DOI]
- Falquez R, "Detaching from the negative by reappraisal: the role of right superior frontal gyrus (BA9", 32), 2014, pp.8, 165~
- Japee S, "A role of right middle frontal gyrus in reorienting of attention: a case study", Front Syst Neurosci, 9, pp.23~ (2015)
- Hampshire A, "The role of the right inferior frontal gyrus: inhibition and attentional control", Neuroimage, 50, pp.1313~1319 (2010)[DOI]
- Charron S, "Divided representation of concurrent goals in the human frontal lobes", Science, 328, pp.360~363 (2010)[DOI]
- Koechlin E, "Broca's area and the hierarchical organization of human behavior", Neuron, 50, pp.963~974 (2006)[DOI]
- Paus T, "Primate anterior cingulate cortex: where motor control, drive and cognition interface", Nat Rev Neurosci, 2, pp.417~424 (2001)[DOI]
- Posner MI, "Attentional networks", Trends Neurosci, 17, pp.75~79 (1994)[DOI]
- Allen P, "Neural correlates of the misattribution of speech in schizophrenia", Br J Psychiatry, 190, pp.162~169 (2007)[DOI]
- McGuire PK, "Increased blood flow in Broca's area during auditory hallucinations in schizophrenia", Lancet, 342, pp.703~706 (1993)[DOI]
- Tolkunov BF, "Involvement of striatum (putamen) neurons in motor and nonmotor behavior fragments in monkeys", Neurosci Behav Physiol, 28, pp.224~230 (1998)[DOI]
- Ueda Y, "Encoding of direction and combination of movements by primate putamen neurons", Eur J Neurosci, 18, pp.980~994 (2003)[DOI]
- Busatto GF, "Schizophrenic auditory hallucinations are associated with increased regional cerebral blood flow during verbal memory activation in a study using single photon emission computed tomography", Psychiatry Res, 61, pp.255~264 (1995)[DOI]
- Shergill SS, "Functional anatomy of auditory verbal imagery in schizophrenic patients with auditory hallucinations", Am J Psychiatry, 157, pp.1691~1693 (2000)[DOI]
- Friederici AD, "The role of left inferior frontal and superior temporal cortex in sentence comprehension: localizing syntactic and semantic processes", Cereb Cortex, 13, pp.170~177 (2003)[DOI]
- Kompus K, "The "paradoxical" engagement of the primary auditory cortex in patients with auditory verbal hallucinations: a meta-analysis of functional neuroimaging studies", Neuropsychologia, 49, pp.3361~3369 (2011)[DOI]
- Chao LL, "Attribute-based neural substrates in temporal cortex for perceiving and knowing about objects", Nat Neurosci, 2, pp.913~919 (1999)[DOI]
- Demonet JF, "The anatomy of phonological and semantic processing in normal subjects", Brain, 115, pp.1753~1768 (1992)[DOI]
- McGuire PK, "Functional anatomy of inner speech and auditory verbal imagery", Psycho Med, 26, pp.29~38 (1996)[DOI]
- Herath P, "Visual recognition: evidence for two distinctive mechanisms from a PET study", Hum Brain Mapp, 12, pp.110~119 (2001)[DOI]
- Penfield W, "Some mechanisms of consciousness discovered during electrical stimulation of the brain", Proc Natl Acad Sci U S A, 44, pp.51~66 (1958)[DOI]
- Frith CD, "Towards a neuropsychology of schizophrenia", Br J Psychiatry, 153, pp.437~443 (1988)[DOI]
- Mechelli A, "Misattribution of speech and impaired connectivity in patients with auditory verbal hallucinations", Hum Brain Mapp, 28, pp.1213~1222 (2007)[DOI]
- Heiss WD, "Metabolic rates in small brain nuclei determined by high-resolution PET", J Nucl Med, 45, pp.1811~1815 (2004)
