본문 바로가기
KERD
논문KCI 등재

Brain Activation Patterns Associated with the Effects of Fearful Distractors during Working Memory Maintenance in Patients with Schizophrenia

2

조회

0

다운로드

0

인용

0

참고문헌

키워드

초록

Objective: The neural correlates underlying the effects of emotional distraction during working memory (WM) tasks in patients with schizophrenia have yet to be clearly identified. Thus, the present study employed functional magnetic resonance imaging (fMRI) to investigate the effects of emotional distraction involving fear during WM maintenance in patients with schizophrenia. Methods: This study included 17 patients with schizophrenia who were diagnosed based on Diagnostic and Statistical Manual of Mental Disorders fourth edition, text revision (DSM-IV-TR) criteria and 17 matched healthy controls. Event-related fMRI data were acquired while the participants performed a delayed-response WM task that included neutral and fearful distractors. Results: Patients with schizophrenia may have tried to maintain WM function during the presentation of task-irrelevant fearful distractors that induced interruption and required attention. Compared to healthy controls, the schizophrenia patients exhibited significantly increased activity in the dorsolateral prefrontal cortex, medial prefrontal cortex, superior temporal gyrus, middle temporal gyrus, insula, hippocampus, caudate nucleus, and postcentral gyrus in a delayed-response WM task when presented with fearful relative to neutral distractors. In addition to its series of increased brain activations, prefrontal areas exhibited interconnections with more caudal brain regions, including temporal areas and the hippocampus and insula. Conclusion: The present study identified specific brain areas associated with the interaction between emotional regulation and cognitive functioning during fearful distractors presented while patients with schizophrenia performed a WM maintenance task. These findings further the current understanding of the neural correlates underlying the effects of emotional distraction on cognitive functioning in patients with schizophrenia.

Abstract

Objective: The neural correlates underlying the effects of emotional distraction during working memory (WM) tasks in patients with schizophrenia have yet to be clearly identified. Thus, the present study employed functional magnetic resonance imaging (fMRI) to investigate the effects of emotional distraction involving fear during WM maintenance in patients with schizophrenia. Methods: This study included 17 patients with schizophrenia who were diagnosed based on Diagnostic and Statistical Manual of Mental Disorders fourth edition, text revision (DSM-IV-TR) criteria and 17 matched healthy controls. Event-related fMRI data were acquired while the participants performed a delayed-response WM task that included neutral and fearful distractors. Results: Patients with schizophrenia may have tried to maintain WM function during the presentation of task-irrelevant fearful distractors that induced interruption and required attention. Compared to healthy controls, the schizophrenia patients exhibited significantly increased activity in the dorsolateral prefrontal cortex, medial prefrontal cortex, superior temporal gyrus, middle temporal gyrus, insula, hippocampus, caudate nucleus, and postcentral gyrus in a delayed-response WM task when presented with fearful relative to neutral distractors. In addition to its series of increased brain activations, prefrontal areas exhibited interconnections with more caudal brain regions, including temporal areas and the hippocampus and insula. Conclusion: The present study identified specific brain areas associated with the interaction between emotional regulation and cognitive functioning during fearful distractors presented while patients with schizophrenia performed a WM maintenance task. These findings further the current understanding of the neural correlates underlying the effects of emotional distraction on cognitive functioning in patients with schizophrenia.

참고문헌 (40)

  1. Nuechterlein KH, "Identification of separable cognitive factors in schizophrenia", Schizophr Res, 72, pp.29~39 (2004)
  2. Adarsh Tripathi, "Cognitive Deficits in Schizophrenia: Understanding the Biological Correlates and Remediation Strategies", Clinical Psychopharmacology and Neuroscience, 16(1), pp.7~17 (2018), 대한정신약물학회[DOI]
  3. 우영섭, "Cognitive Deficits as a Mediator of Poor Occupational Function in Remitted Major Depressive Disorder Patients", Clinical Psychopharmacology and Neuroscience, 14(1), pp.1~16 (2016), 대한정신약물학회
  4. Baddeley AD, "Working memory" (1986), Oxford University Press
  5. Dolcos F, "Regional brain differences in the effect of distraction during the delay interval of a working memory task", Brain Res, 1152, pp.171~181 (2007)
  6. Ellis HC, "Affect, cognition, and social behavior: new evidence and integrative attempts", pp.25~43 (1988), Hogrefe
  7. Oltmanns TF, "Schizophrenic performance when distractors are present : attentional deficit or differential task difficulty", J Abnorm Psychol, 84, pp.205~209 (1975)
  8. Hahn B, "Failure of schizophrenia patients to overcome salient distractors during working memory encoding", Biol Psychiatry, 68, pp.603~609 (2010)
  9. 최지욱, "Dysfunction of the Left Dorsolateral Prefrontal Cortex is Primarily Responsible for Impaired Attentional Processing in Schizophrenia", PSYCHIATRY INVESTIGATION, 5(1), pp.52~59 (2008), 대한신경정신의학회
  10. Weiss EM, "Brain activation patterns during a selective attention test-a functional MRI study in healthy volunteers and patients with schizophrenia", Psychiatry Res, 123, pp.1~15 (2003)
  11. Dolcos F, "Opposing influences of emotional and non-emotional distracters upon sustained prefrontal cortex activity during a delayed-response working memory task", Neuropsychologia, 46, pp.326~335 (2008)
  12. First MB, "Structured clinical interview for DSM-IV-TR Axis I disorders: Patient edition", Biometrics Research Department, Columbia University, ~ (2005)
  13. Kay SR, "The positive and negative syndrome scale(PANSS)for schizophrenia", Schizophr Bull, 13, pp.261~276 (1987)
  14. 이중서, "한국판 양성 및 음성증후군 척도(Positive and Negative Syndrome Scale)의 신뢰도와 타당도", 신경정신의학, 40(6), pp.1090~1105 (2001), 대한신경정신의학회
  15. Haro JM, "The Clinical Global Impression-Schizophrenia scale: a simple instrument to measure the diversity of symptoms present in schizophrenia", Acta Psychiatr Scand Suppl, (416), pp.16~23 (2003)
  16. Lang PJ, "International affective picture system (IAPS): Affective ratings of pictures and instruction manual" (2005), NIMH, Center for the Study of Emotion & Attention
  17. Potkin SG, "Working memory and DLPFC inefficiency in schizophrenia : the FBIRN study", Schizophr Bull, 35, pp.19~31 (2009)
  18. Barbey AK, "Dorsolateral prefrontal contributions to human working memory", Cortex, 49, pp.1195~1205 (2013)
  19. Weinberger DR, "Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia. I. Regional cerebral blood flow evidence", Arch Gen Psychiatry, 43, pp.114~124 (1986)
  20. Manoach DS, "Schizophrenic subjects activate dorsolateral prefrontal cortex during a working memory task, as measured by fMRI", Biol Psychiatry, 45, pp.1128~1137 (1999)
  21. Manoach DS, "Schizophrenic subjects show aberrant fMRI activation of dorsolateral prefrontal cortex and basal ganglia during working memory performance", Biol Psychiatry, 48, pp.99~109 (2000)
  22. Watts FN, "Associations between phenomenal and objective aspects of concentration problems in depressed patients", Br J Psychol, 79, pp.241~250 (1988)
  23. Courtney SM, "Transient and sustained activity in a distributed neural system for human working memory", Nature, 386, pp.608~611 (1997)
  24. Smith EE, "Storage and executive processes in the frontal lobes", Science, 283, pp.1657~1661 (1999)
  25. Davidson RJ, "The functional neuroanatomy of emotion and affective style", Trends Cogn Sci, 3, pp.11~21 (1999)
  26. Phan KL, "Functional neuroanatomy of emotion : a meta-analysis of emotion activation studies in PET and fMRI", Neuroimage, 16, pp.331~348 (2002)
  27. Zald DH, "The human amygdala and the emotional evaluation of sensory stimuli", Brain Res Rev, 41, pp.88~123 (2003)
  28. Whitfield-Gabrieli S, "Hyperactivity and hyperconnectivity of the default network in schizophrenia and in first-degree relatives of persons with schizophrenia", Proc Natl Acad Sci U S A, 106, pp.1279~1284 (2009)
  29. Frith CD, "Regional brain activity in chronic schizophrenic patients during the performance of a verbal fluency task", Br J Psychiatry, 167, pp.343~349 (1995)
  30. Walter H, "Working memory dysfunction in schizophrenia compared to healthy controls and patients with depression : evidence from event-related fMRI", Neuroimage, 35, pp.1551~1561 (2007)
  31. Crossley NA, "Superior temporal lobe dysfunction and frontotemporal dysconnectivity in subjects at risk of psychosis and in first-episode psychosis", Hum Brain Mapp, 30, pp.4129~4137 (2009)
  32. Tura E, "Multivariate analyses suggest genetic impacts on neurocircuitry in schizophrenia", Neuroreport, 19, pp.603~607 (2008)
  33. Critchley H, "Explicit and implicit neural mechanisms for processing of social information from facial expressions : a functional magnetic resonance imaging study", Hum Brain Mapp, 9, pp.93~105 (2000)
  34. Lange K, "Task instructions modulate neural responses to fearful facial expressions", Biol Psychiatry, 53, pp.226~232 (2003)
  35. Phillips ML, "Neural responses to facial and vocal expressions of fear and disgust", Proc Biol Sci, 265, pp.1809~1817 (1998)
  36. Critchley HD, "Fear conditioning in humans : the influence of awareness and autonomic arousal on functional neuroanatomy", Neuron, 33, pp.653~663 (2002)
  37. Phan KL, "Neural correlates of individual ratings of emotional salience : a trial-related fMRI study", Neuroimage, 21, pp.768~780 (2004)
  38. Critchley HD, "Neural systems supporting interoceptive awareness", Nat Neurosci, 7, pp.189~195 (2004)
  39. Augustine JR, "The insular lobe in primates including humans", Neurol Res, 7, pp.2~10 (1985)
  40. Paulus MP, "Superior temporal gyrus and insula provide response and outcome-dependent information during assessment and action selection in a decision-making situation", Neuroimage, 25, pp.607~615 (2005)

관련 논문AI추천

Gray Matter Microstructural Abnormalities and Working Memory Deficits in Individuals with SchizophreniaHyunJung Kim, Jang-Han Lee, Ji-Won Hur, Jung Sun Lee, Seung-Hyun Shon, Sung Woo Joo, Woon Yoon대한신경정신의학회 · PSYCHIATRY INVESTIGATION2019 · 제16권 제3호유년기 정신적 외상을 경험한 외상후 스트레스장애 환자에서 무의식적 감정 자극이 의식적 작업기억 수행에 미치는 영향에 관한 기능적 자기공명영상 연구김광원, 박종일, 양종철, 엄준선한국정신분석학회 · 정신분석2019 · 제30권 제4호Attentional impairment in patients with schizophrenia김소연한국인지및생물심리학회 · 한국심리학회지: 인지 및 생물2016 · 제28권 제1호Neuronal Signatures of Negative and Positive Schemas towards the Self and Others in Patients with Early Stage SchizophreniaChung Young-Chul, Congcong Liu, Guangfan Shen, Jie Shen, Jing Sui, Kim Woo-Sung, Uyanga Tsogt대한신경정신의학회 · PSYCHIATRY INVESTIGATION2021 · 제18권 제4호Alteration of Semantic Networks during Swear Words Processing in SchizophreniaBumseok Jeong, Guang Fan Shen, Gyung Ho Chung, Hyo-Jong Lee, Il Seok Oh, Jong-Il Park, Kang Han Oh, Sang Won Lee, Woo-Sung Kim, Yin Cui, Young-Chul Chung대한정신약물학회 · Clinical Psychopharmacology and Neuroscience2019 · 제17권 제1호Abnormal frontal activation during the perception of biological motion in patients with schizophrenia김제중한국인지및생물심리학회 · 한국심리학회지: 인지 및 생물2014 · 제26권 제4호

이 간행물의 다른 논문 (16건)