Neural Basis of Ambivalence towards Ideal Self-Image in Schizophrenia
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Objective Little has been explored about a reflection towards self-image in schizophrenia, though it can be related to heterogeneous symptoms of the illness. We identified the neural basis of ambivalence towards ideal self-image in patients with schizophrenia. Methods 20 patients with schizophrenia and 20 healthy controls underwent functional MRI while the self-image reflection tasks of determining whether to agree with sentences describing their actual or ideal self-image that contained one of the adjective pairs with opposite valence. The interaction between the group and ideal ambivalence score was examined, and group differences in functional connectivity related to ambivalence towards ideal self-image were further studied. Results The interaction of group-by-ideal ambivalence score was shown in the dorsal anterior cingulate cortex and dorsolateral prefrontal cortex, where activities were positively correlated with the level of ideal self-image ambivalence in patients, but not in controls. Task-related decrease in functional connectivity was shown between the orbitofrontal cortex and cerebellum in patients. Conclusion The process of reflecting on ambivalent ideal self-image in schizophrenia may be related to aberrant prefrontal activity and connectivity. Abnormality in the prefrontal regions that take part in cognitive conflict monitoring and value judgment may underlie the pathophysiology of increased ambivalence towards ideal self-image.
Abstract
Objective Little has been explored about a reflection towards self-image in schizophrenia, though it can be related to heterogeneous symptoms of the illness. We identified the neural basis of ambivalence towards ideal self-image in patients with schizophrenia. Methods 20 patients with schizophrenia and 20 healthy controls underwent functional MRI while the self-image reflection tasks of determining whether to agree with sentences describing their actual or ideal self-image that contained one of the adjective pairs with opposite valence. The interaction between the group and ideal ambivalence score was examined, and group differences in functional connectivity related to ambivalence towards ideal self-image were further studied. Results The interaction of group-by-ideal ambivalence score was shown in the dorsal anterior cingulate cortex and dorsolateral prefrontal cortex, where activities were positively correlated with the level of ideal self-image ambivalence in patients, but not in controls. Task-related decrease in functional connectivity was shown between the orbitofrontal cortex and cerebellum in patients. Conclusion The process of reflecting on ambivalent ideal self-image in schizophrenia may be related to aberrant prefrontal activity and connectivity. Abnormality in the prefrontal regions that take part in cognitive conflict monitoring and value judgment may underlie the pathophysiology of increased ambivalence towards ideal self-image.
참고문헌 (49)
- Sass LA, "Schizophrenia, consciousness, and the self", Schizophr Bull, 29, pp.427~444 (2003)
- Moe AM, "Schizophrenia and the sense of self", Schizophr Bull, 40, pp.161~168 (2014)
- Tangney JP, "Are shame and guilt related to distinct self-discrepancies? A test of Higgins’s(1987)hypotheses", J Pers Soc Psychol, 75, pp.256~268 (1998)
- Higgins ET, "Self-discrepancy : a theory relating self and affect", Psychol Rev, 94, pp.319~340 (1987)
- Bhar SS, "An investigation of self-ambivalence in obsessivecompulsive disorder", Behav Res Ther, 45, pp.1845~1857 (2007)
- Kinderman P, "Self-discrepancies, attentional bias and persecutory delusions", Br J Clin Psychol, 42, pp.1~12 (2003)
- Tiernan B, "Paranoia and self-concepts in psychosis : a systematic review of the literature", Psychiatry Res, 216, pp.303~313 (2014)
- Trémeau F, "In support of Bleuler : objective evidence for increased affective ambivalence in schizophrenia based upon evocative testing", Schizophr Res, 107, pp.223~231 (2009)
- Docherty AR, "Self-reported ambivalence in schizophrenia and associations with negative mood", J Nerv Ment Dis, 202, pp.70~73 (2014)
- Docherty AR, "Further examination of ambivalence in relation to the schizophrenia spectrum", Schizophr Res, 158, pp.261~263 (2014)
- Raulin ML, "Symptoms of Schizophrenia", pp.201~226 (1993), Wiley
- D’Argembeau A, "On the role of the ventromedial prefrontal cortex in self-processing : the valuation hypothesis", Front Hum Neurosci, 7, pp.372~ (2013)
- Mansouri FA, "Conflict-induced behavioural adjustment : a clue to the executive functions of the prefrontal cortex", Nat Rev Neurosci, 10, pp.141~152 (2009)
- Holt DJ, "An anterior-to-posterior shift in midline cortical activity in schizophrenia during self-reflection", Biol Psychiatry, 69, pp.415~423 (2011)
- Shad MU, "Neurobiology of self-awareness in schizophrenia : an fMRI study", Schizophr Res, 138, pp.113~119 (2012)
- Albrecht MA, "Probability and magnitude evaluation in schizophrenia", Schizophr Res Cogn, 5, pp.41~46 (2016)
- Strauss GP, "Patients with schizophrenia demonstrate inconsistent preference judgments for affective and nonaffective stimuli", Schizophr Bull, 37, pp.1295~1304 (2011)
- Dehaene S, "Conscious and subliminal conflicts in normal subjects and patients with schizophrenia : the role of the anterior cingulate", Proc Natl Acad Sci U S A, 100, pp.13722~13727 (2003)
- Kerns JG, "Decreased conflict-and error-related activity in the anterior cingulate cortex in subjects with schizophrenia", Am J Psychiatry, 162, pp.1833~1839 (2005)
- Miller EK, "The prefrontal cortex and cognitive control", Nat Rev Neurosci, 1, pp.59~65 (2000)
- Sambataro F, "Altered cerebral response during cognitive control : a potential indicator of genetic liability for schizophrenia", Neuropsychopharmacology, 38, pp.846~853 (2013)
- Spitzer RL, "Structured Clinical Interview for DSM-IV" (1994), Biometrics Research
- Beck AT, "An inventory for measuring depression", Arch Gen Psychiatry, 4, pp.561~571 (1961)
- Kay SR, "The positive and negative syndrome scale(PANSS)for schizophrenia", Schizophr Bull, 13, pp.261~276 (1987)
- Spitzer RL, "Outcomes Assessment in Clinical Practice", pp.76~78 (1996), Williams & Wilkins
- Priester JR, "The gradual threshold model of ambivalence : relating the positive and negative bases of attitudes to subjective ambivalence", J Pers Soc Psychol, 71, pp.431~449 (1996)
- Whitfield-Gabrieli S, "Conn : a functional connectivity toolbox for correlated and anticorrelated brain networks", Brain Connect, 2, pp.125~141 (2012)
- Martuzzi R, "A whole-brain voxel based measure of intrinsic connectivity contrast reveals local changes in tissue connectivity with anesthetic without a priori assumptions on thresholds or regions of interest", Neuroimage, 58, pp.1044~1050 (2011)
- Marchand WR, "Differences in functional connectivity in major depression versus bipolar II depression", J Affect Disord, 150, pp.527~532 (2013)
- H2O PET study, "J Int Neuropsychol Soc", 2009, 990~1001
- Chun JW, "Contribution of fronto-striatal regions to emotional valence and repetition under cognitive conflict", Brain Res, 1666, pp.48~57 (2017)
- Medalla M, "Synapses with inhibitory neurons differentiate anterior cingulate from dorsolateral prefrontal pathways associated with cognitive control", Neuron, 61, pp.609~620 (2009)
- van Veen V, "Anterior cingulate cortex, conflict monitoring, and levels of processing", Neuroimage, 14, pp.1302~1308 (2001)
- Dehaene S, "Conscious and subliminal conflicts in normal subjects and patients with schizophrenia : the role of the anterior cingulate", Proc Natl Acad Sci U S A, 100, pp.13722~13727 (2003)
- Koechlin E, "An information theoretical approach to prefrontal executive function", Trends Cogn Sci, 11, pp.229~235 (2007)
- Chambon V, "The architecture of cognitive control in schizophrenia", Brain, 131, pp.962~970 (2008)
- Barch D, "Cognition in schizophrenia : core psychological and neural mechanisms", Trends Cogn Sci, 16, pp.27~34 (2012)
- Mann MC, "The schizotypal ambivalence scale as a marker of schizotypy", J Nerv Ment Dis, 196, pp.399~404 (2008)
- Johnson SC, "Neural correlates of self-reflection", Brain, 125, pp.1808~1814 (2002)
- Northoff G, "Cortical midline structures and the self", Trends Cogn Sci, 8, pp.102~107 (2004)
- Fellows LK, "Orbitofrontal contributions to value-based decision making : evidence from humans with frontal lobe damage", Ann N Y Acad Sci, 1239, pp.51~58 (2011)
- Andreasen NC, "“Cognitive dysmetria” as an integrative theory of schizophrenia: a dysfunction in cortical-subcortical-cerebellar circuitry?", Schizophr Bull, 24, pp.203~218 (1998)
- Shinn AK, "Aberrant cerebellar connectivity in motor and association networks in schizophrenia", Front Hum Neurosci, 9, pp.134~ (2015)
- Der-Avakian A, "The neurobiology of anhedonia and other reward-related deficits", Trends Neurosci, 35, pp.68~77 (2012)
- Hare TA, "Dissociating the role of the orbitofrontal cortex and the striatum in the computation of goal values and prediction errors", J Neurosci, 28, pp.5623~5630 (2008)
- Gallagher M, "Orbitofrontal cortex and representation of incentive value in associative learning", J Neurosci, 19, pp.6610~6614 (1999)
- Strauss GP, "Anhedonia reflects impairment in making relative value judgments between positive and neutral stimuli in schizophrenia", Schizophr Res, 197, pp.156~161 (2018)
- Brady RO Jr, "Cerebellar-prefrontal network connectivity and negative symptoms in schizophrenia", Am J Psychiatry, 176, pp.512~520 (2019)
- Lui S, "Short-term effects of antipsychotic treatment on cerebral function in drug-naive first-episode schizophrenia revealed by"resting state"functional magnetic resonance imaging", Arch Gen Psychiatry, 67, pp.783~792 (2010)
