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한국인 성인 여성에서 osteoprotegerin 유전자 다형성과 대동맥 석회화의 관련성

The relationship between osteoprotegerin gene polymorphism and aortic calcification in Korean women

오은숙|백기현|윤건호|박철영|임성희|강무일|최문기|유형준|박성우|이은정|윤은주|이원영|오기원
대한내과학회 (The Korean Association Of Internal Medicine)|2006.01|대한내과학회지 (The Korean Journal of Medicine)|제70권 제1호|pp. 41-52

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키워드

Polymorphism유전자 다형성Osteoprotegerin대동맥석회화Aortic Calcification
주제분류내과학

초록

목적 : Osteoprotegerin (OPG)은 receptor activator of NF-κB ligand (RANKL)의 decoy receptor로 동물실험에서 골흡수의 중요한 억제인자이며 동맥 석회화에도 관련되어 있다. 최근 OPG는 골다공증과 동맥 석회화 사이의 연결 기전 중의 하나로 추정되고 있으나 사람에서 OPG 유전자와 심혈관계 질환 사이의 관계는 명확히 알려져 있지 않다. 이에 연구자들은 건강한 한국인 여성에서 OPG 유전자 다형성과 대동맥 석회화의 상호관계를 관찰하였다.방법 : 건강한 251명의 한국인 여성(평균 연령, 51.3±6.9세)에서 OPG 유전자 A163G, G209A, T245G, T950C 부위의 유전자 다형성과 흉부 및 복부 대동맥 석회화, 혈청 OPG 농도 및 심혈관계 질환의 위험인자의 상호관계를 조사하였다.결과 : OPG 유전자의 G209A과 T950C 부위의 동종접합체 및 이종접합체 유전자형은 대동맥 석회화 존재 군에서 대동맥 석회화가 없는 군보다 높은 빈도로 관찰되었다(G209A, 28.6% vs. 18.7%, p=0.029; T950C, 75.9% vs. 65.4%, p=0.017). 한편 OPG 유전자의 유전자 다형성은 혈청 OPG 농도 및 심혈관계 질환의 위험인자와는 연관성이 관찰되지 않았다.

Abstract

Background : Osteoprotegerin (OPG) is a recently identified cytokine that acts as a decoy receptor for the receptor activator of NF-κB ligand (RANKL). OPG has been shown to be an important inhibitor of osteoclastogenesis and arterial calcification in animal models. Recently, OPG has been proposed as a link molecule between osteoporosis and arterial calcification, but the relationship between OPG gene and cardiovascular system in human populations is unclear. Thus, the aim of this study was to investigate the relationship between OPG gene polymorphisms and aortic calcification in healthy Korean women. Methods : We observed 251 healthy Korean women (mean age, 51.3±6.9 yr). We determined cardiovascular risk factors. Thoracic and abdominal aortic calcifications were examined by simple radiological methods. A163G, G209A, T245G, and T950C polymorphisms of OPG gene were analyzed by allelic discrimination using the 5' nuclease polymerase chain reaction assay. Results : The frequency of mutant allele was increased in the aortic calcification (+) group as compared with aortic calcification (-) group (G209A, 28.6% vs. 18.7%, p=0.029; T950C, 75.9% vs.65.4%, p=0.017). However, no significant relationship was found between OPG gene polymorphisms and serum OPG levels and cardiovascular risk factors. Conclusions : We observed that the OPG gene polymorphisms were partly associated with aortic calcification in healthy Korean women. Further studies are needed to clarify this relationship.(Korean J Med 70:41-52, 2006)

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한국 폐경 여성에서 Sclerostin (SOST) 유전자 다형성과 골밀도 및 순환계 Osteoprotegerin (OPG)–용질성 Receptor Activator of NF-κB Ligand (sRANKL) 사이의 연관성김훈, 구승엽, 김석현, 김정구, 이희준, 최영민대한골다공증학회 · OSTEOPOROSIS2012 · 제10권 제3호Osteoprotegerin(OPG)-receptor Activator of NF-kB Ligand(RANKL) 유전자 다형성과 전혈세포에서의 OPG, sRANKL 생산 사이의 연관성김훈, 김석현, 김용진, 김정구, 문신용, 박경아, 서창석, 채수진, 최영민대한골다공증학회 · OSTEOPOROSIS2007 · 제5권 제1호Secreted Frizzled 연관 단백계 유전자 다형성과 순환계 Osteoprotegerin (OPG) - 용질성 Receptor Activator of NF-kB Ligand (sRANKL) 및 골밀도 사이의 연관성김훈, 구승엽, 김석현, 김정구, 이동옥, 최영민대한골다공증학회 · OSTEOPOROSIS2011 · 제9권 제2호Wnt 신호전달계 내 유전자 다형성과 전혈세포에서의 Osteoprotegerin 및 Soluble Receptor Activator of NF-kB Ligand 생산 사이의 연관성김훈, 구승엽, 김석현, 김정구, 서창석, 이동윤, 최영민대한골다공증학회 · OSTEOPOROSIS2010 · 제8권 제2호자연폐경 한국여성에서 종양괴사인자 유전자 다형성과 호르몬치료 후 골밀도 변화 사이의 연관성에 관한 연구김정구, 전성욱대한골다공증학회 · OSTEOPOROSIS2011 · 제9권 제1호성인 여성에서 혈청 Osteoprotegerin 농도와 골대사의 관련성강무일, 박경창, 박성우, 박철영, 백기현, 오기원, 오은숙, 유형준, 윤은주, 이원영, 이은정, 최문기대한내과학회 · 대한내과학회지2004 · 제66권 제1호

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