본문 바로가기
KERD
논문KCI 등재후보

자연폐경 한국여성에서 종양괴사인자 유전자 다형성과 호르몬치료 후 골밀도 변화 사이의 연관성에 관한 연구

The Relationship between Polymorphisms in Tumor Necrosis Factor (TNF) Genes and Changes in Bone Mineral Density after Hormone Therapy in Postmenopausal Korean Women

2

조회

0

다운로드

0

인용

0

참고문헌

키워드

주제분류기타의약학

초록

Objectives: To determine the association between polymorphisms in tumor necrosis factor-α (TNF-α), and TNF-β genes, and changes in bone mineral density (BMD) after hormone therapy (HT) in postmenopausal Korean women. Materials & Methods: The TNF-α G(-308)A, C(-857)T, C(-863)A, T(-1031)C, and TNF-β A252G polymorphisms were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) or Taqman assay in 218 postmenopausal Korean women receiving sequential HT for 1 year. Bone mineral density (BMD) at the lumbar spine and femoral neck was examined by dual energy X-ray absorptiometry. Serum levels of bone specific alkaline phosphatase (BAP), osteocalcin (OST), type I C-telopeptide breakdown products (CTX), parathyroid hormone (PTH), calcium, and phosphorus were measured using enzyme-linked immunosorbent assay (ELISA), immunoassay, and atomic absorptiometry, respectively. Results: No significant associations were found between single genotypes of TNF-α, or TNF-β polymorphisms and the annual percentage changes of BMD at the lumbar spine and femoral neck after HT. Haplotype analysis of 4 TNF-α polymorphisms did not show any significant association with the annual percentage changes of BMD at the lumbar spine and femoral neck after HT. The changes in serum levels of bone markers 6 months after HT were not related with single genotypes or haplotype genotypes of TNF polymorphisms. The distribution of these single or haplotype genotypes were not different between HT responders and HT non-responders (women who lose >3% of bone mass per year). Conclusions: The TNF-α G(-308)A, C(-857)T, C(-863)A, T(-1031)C, and TNF-β A252G polymorphisms are not associated with changes in BMD after HT in postmenopausal Korean women.

Abstract

Objectives: To determine the association between polymorphisms in tumor necrosis factor-α (TNF-α), and TNF-β genes, and changes in bone mineral density (BMD) after hormone therapy (HT) in postmenopausal Korean women. Materials & Methods: The TNF-α G(-308)A, C(-857)T, C(-863)A, T(-1031)C, and TNF-β A252G polymorphisms were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) or Taqman assay in 218 postmenopausal Korean women receiving sequential HT for 1 year. Bone mineral density (BMD) at the lumbar spine and femoral neck was examined by dual energy X-ray absorptiometry. Serum levels of bone specific alkaline phosphatase (BAP), osteocalcin (OST), type I C-telopeptide breakdown products (CTX), parathyroid hormone (PTH), calcium, and phosphorus were measured using enzyme-linked immunosorbent assay (ELISA), immunoassay, and atomic absorptiometry, respectively. Results: No significant associations were found between single genotypes of TNF-α, or TNF-β polymorphisms and the annual percentage changes of BMD at the lumbar spine and femoral neck after HT. Haplotype analysis of 4 TNF-α polymorphisms did not show any significant association with the annual percentage changes of BMD at the lumbar spine and femoral neck after HT. The changes in serum levels of bone markers 6 months after HT were not related with single genotypes or haplotype genotypes of TNF polymorphisms. The distribution of these single or haplotype genotypes were not different between HT responders and HT non-responders (women who lose >3% of bone mass per year). Conclusions: The TNF-α G(-308)A, C(-857)T, C(-863)A, T(-1031)C, and TNF-β A252G polymorphisms are not associated with changes in BMD after HT in postmenopausal Korean women.

참고문헌 (40)

  1. NIH Consensus development panel, "Osteoporosis prevention, diagnosis, and therapy", JAMA, 285, pp.785~795 (2001)
  2. Krall EA, "Heritable and life style determinants of bone mineral density", J Bone Miner Res, 8, pp.1~9 (1993)
  3. Gennari L, "Genetics of osteoporosis: role of steroid hormone receptor gene polymorphisms", J Steroid Biochem Mol Biol, 81, pp.1~24 (2002)
  4. MacGregor A, "Genetic factors and osteoporotic fractures in elderly people. Twin data support genetic contribution to risk of fracture", BMJ, 320, pp.1669~ (2000)
  5. Morrison NA, "Prediction of bone density from vitamin D receptor alleles", Nature, 367, pp.284~287 (1994)
  6. Kobayashi S, "Association of bone mineral density with polymorphism of the estrogen receptor gene", J Bone Miner Res, 11, pp.306~311 (1996)
  7. Grant SF, "Reduced bone density and osteoporosis associated with a polymorphic Sp1 binding site in the collagen type I alpha 1 gene", Nat Genet, 14, pp.203~205 (1996)
  8. Liu YZ, "Molecular studies of identification of genes for osteoporosis: the 2002 update", J Endocrinol, 177, pp.147~196 (2003)
  9. Kim JG, "Association of vitamin D receptorand estrogen receptor gene polymorphisms with bone mass in postmenopausal Korean women", Menopause, 8, pp.222~228 (2001)
  10. 김정구, "한국 폐경여성에서 비타민 D 수용체 유전자 다형성과 골밀도의 연관성", Obstetrics & Gynecology Science, 45(11), pp.15~15 (2002), 대한산부인과학회
  11. 김정구, "한국 폐경여성에서 비타민 D 수용체 유전자내 Poly (A) 다형성과 골밀도의 연관성", Obstetrics & Gynecology Science, 46(4), pp.16~16 (2003), 대한산부인과학회
  12. Kim JG, "The relationship among serum insulin-like growth factor-I, insulin-like growth factor-I gene polymorphism and bone mineral density in postmenopausal women in Korea", Am J Obstet Gynecol, 186, pp.345~350 (2002)
  13. Kim JG, "Association between osteoprotegerin (OPG), receptor activator of nuclear factor-kappaB (RANK), and RANK ligand (RANKL) gene polymorphisms and circulating OPG, soluble RANKL levels, and bone mineral density in Korean postmenopausal women", Menopause, 14, pp.913~918 (2007)
  14. Pines A, "IMS updated recommendations on postmenopausal hormone therapy", Climacteric, 10, pp.181~194 (2007)
  15. Writing Group for the Women's Health Initiative Investigators, "Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial", JAMA, 288, pp.321~333 (2002)
  16. The Women's Health Initiative Steering Committee, "Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women's Health Initiative randomized controlled trial", JAMA, 291, pp.1701~1712 (2004)
  17. Hassager C, "Nonresponders to hormone replacement therapy for the prevention of postmenopausal bone loss: Do they exist", Osteoporosis Int, 4, pp.36~41 (1994)
  18. Kurabayashi T, "Association of vitamin D and estrogen receptor gene polymorphism with the effect of hormone replacement therapy on bone mineral density in Japanese women", Am J Obstet Gynecol, 180, pp.1115~1120 (1999)
  19. Deng HW, "Change of bone mass in postmenopausal Caucasian women with and without hormone re placement therapy is associated with vitamin D receptor and estrogen receptor genotypes", Hum Genet, 103, pp.576~585 (1998)
  20. Yamada Y, "Association of transforming growth factor beta1 genotype with therapeutic response to active vitamin D for postmenopausal osteoporosis", J Bone Miner Res, 15, pp.415~420 (2000)
  21. 김정구, "한국 폐경여성에서 비타민 D 수용체 유전자 다형성과 호르몬대체요법이 골밀도에 미치는 영향과의 연관성", Obstetrics & Gynecology Science, 46(5), pp.15~15 (2003), 대한산부인과학회
  22. Kim JG, "The Calcitonin Gene (CA) Polymorphism, Bone Mineral Density, and Bone responsiveness to Hormone Treatment in Postmenopausal Korean Women", Korean J Osteoporosis, 1, pp.130~139 (2003)
  23. Kim JH, "The Change of Bone Mineral Density afterHormone Replacement Therapyaccording to CA Repaet Polymorphism inInsulin-Like Growth factor (IGF)-I Gene", JKSM, 1, pp.217~225 (2003)
  24. Weitzmann MN, "Estrogen deficiency and bone loss: an inflammatory tale", J Clin Invest, 116, pp.1186~1194 (2006)
  25. Roggia C, "Role of TNF-α producing T-cells in bone loss induced by estrogen deficiency", Minerva Med, 95, pp.125~132 (2004)
  26. Roggia C, "Up-regulation of TNFproducing T cells in the bone marrow: a key mechanism by which estrogen deficiency induces bone loss in vivo", Proc Natl Acad Sci USA, 98, pp.13960~13965 (2001)
  27. Ota N, "Association of a single nucleotide variant in the human tumour necrosis factor alpha promoter region with decreased bone mineral density", Ann Hum Biol, 29, pp.550~558 (2002)
  28. Furuta I, "Bone mineral density of the lumbar spine is associated with TNF gene polymorphisms in early postmenopausal Japanese women", Calcif Tissue Int, 74, pp.509~515 (2004)
  29. Lee N, "Tumor necrosis factor-alpha haplotype is strongly ssociated with bone mineral density in patients with Crohn's disease", J Gastroenterol Hepatol, 22, pp.913~919 (2007)
  30. Fontova R, "Bone mineral mass is associated with interleukin 1 receptor autoantigen and TNF-alpha gene polymorphisms in postmenopausal Mediterranean women", J Endocrinol Invest, 25, pp.684~690 (2002)
  31. Wennberg P, "TNF-alpha gene polymorphism and plasma TNF-alpha levels are related to lumbar spine bone area in healthy female Caucasian adolescents", Eur J Endocrinol, 146, pp.629~634 (2002)
  32. Chen HY, "Tumor necrosis factor alpha, CYP 17, urokinase, and interleukin 10 gene polymorphisms in postmenopausal women: correlation to bone mineral density and susceptibility to osteoporosis", Eur J Obstet Gynecol Reprod Biol, 122, pp.73~78 (2005)
  33. Xiao P, "Association tests of interleukin-6 (IL-6) and type II tumor necrosis factor receptor (TNFR2) genes with bone mineral density in Caucasians using a re-sampling approach", Hum Genet, 117, pp.340~348 (2005)
  34. Santos JL, "Adiposity and bone mineral density of Chilean elderly women in relation to toll-like receptor 4 gene polymorphisms", Ann Hum Biol, 33, pp.585~592 (2006)
  35. Pacifici R, "Effect of surgical menopause and estrogen replacement on cytokine release from human blood mononuclear cells", Proc Natl Acad Sci USA, 88, pp.5134~5138 (1991)
  36. Vural P, "Effects of hormone replacement therapy on plasma pro-inflammatory and anti-inflammatory cytokines and some bone turnover markers in postmenopausal women", Pharmacol Res, 54, pp.298~302 (2006)
  37. Han KO, "Nonassociation of estrogen receptor genotypes with bone mineral density and estrogen responsiveness to hormone replacement therapy in Korean postmenopausal women", J Clin Endocrinol Metab, 82, pp.991~995 (1997)
  38. Chun S, "The Relationship between Tumor Necrosis Factor (TNF)-TNF Receptor (TNFR) Gene Polymorphisms and the Production of TNF and Soluble TNFR (sTNFR) by Whole Blood Cells in Korean Postmenopausal Women", JKSM, 14, pp.227~237 (2008)
  39. Kim H, "The Relationship between Changes in the Production of Tumor Necrosis Factor (TNF)-α, TNF-β, Soluble TNF Receptor 1 (sTNFR1), sTNFR2 by Whole Blood Cells and Changes in Bone Mineral Density after Estrogen-progestogen Therapy in Postmenopausal Women", JKSM, 14, pp.139~148 (2008)
  40. The Korean Society of Bone Metabolism, "osteoporosi", pp.19~26 (2006), Hanmi Book

관련 논문AI추천

폐경여성에서 Fas, Fas-ligand 유전자 다형성과 골밀도와의 연관성권동진, 김진홍, 변승원, 유영옥대한산부인과학회 · Obstetrics & Gynecology Science2007 · 제50권 제10호한국 폐경여성에서 비타민 D 수용체 유전자 다형성과 호르몬대체요법이 골밀도에 미치는 영향과의 연관성김석현, 김정구, 문신용, 이진용, 최영민대한산부인과학회 · Obstetrics & Gynecology Science2003 · 제46권 제5호한국 폐경여성에서 interleukin-6 유전자 G(-634)C 다형성과 호르몬 치료후 골밀도 변화사이의 연관성김정구, 이동윤대한산부인과학회 · Obstetrics & Gynecology Science2005 · 제48권 제9호한국 폐경여성에서 부갑상선 호르몬 유전자 BstBI 다형성과골밀도 및 호르몬대체요법에 대한 골반응도 사이의 연관성구승엽, 김석현, 김정구, 문신용, 이진용, 최영민대한산부인과학회 · Obstetrics & Gynecology Science2004 · 제47권 제4호한국인 자연폐경 여성에서 Fas 유전자 다형성과 골밀도와의 연관성권동진, 김대훈, 김장흡, 김진홍, 송민종, 유영옥대한산부인과학회 · Obstetrics & Gynecology Science2006 · 제49권 제1호한국 폐경 여성에서 Sclerostin (SOST) 유전자 다형성과 골밀도 및 순환계 Osteoprotegerin (OPG)–용질성 Receptor Activator of NF-κB Ligand (sRANKL) 사이의 연관성김훈, 구승엽, 김석현, 김정구, 이희준, 최영민대한골다공증학회 · OSTEOPOROSIS2012 · 제10권 제3호

이 간행물의 다른 논문 (15건)